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Pain General

A combination of pain indices based on momentary assessments can predict placebo response in patients with fibromyalgia syndrome.

Aug 13, 2020

Many factors are known to affect assay sensitivity; however, limited attention has been devoted to understanding whether characteristics of patients' baseline pain impact assay sensitivity. In this st...

Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial.

Aug 13, 2020

Fibromyalgia is a common and challenging chronic pain disorder with few, if any, highly effective and well tolerated treatments. Alpha-lipoic acid (ALA) is a non-sedating antioxidant with evidence of ...

Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains.

Aug 13, 2020

Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown. Females are more commonly affected by fibromyalgia, ...

Hydrogen sulfide: an endogenous regulator of the immune system.

Aug 13, 2020

Hydrogen sulfide (HS) is now recognized as an endogenous signaling gasotransmitter in mammals. It is produced by mammalian cells and tissues by various enzymes - predominantly cystathionine β-synthas...

Palmitic acid-modified bovine serum albumin nanoparticles target scavenger receptor-A on activated macrophages to treat rheumatoid arthritis.

Aug 13, 2020

Palmitic acid-modified bovine serum albumin (PAB) was synthetized and found to own remarkable scavenger receptor-A (SR-A) targeting ability in vitro and in vivo, through which activated macrophages to...

The Impact of Hydromorphone & Infective Endocarditis

Aug 10, 2020

The rate of infective endocarditis (IE) in people who inject drugs (PWID) has been rapidly increasing in recent years, explains Michael Silverman, MD. Dr. Silverman and colleagues hypothesized that th...

Convolutional Neural Network Based Dosimetry Evaluation for Esophageal Radiation Treatment Planning.

Aug 10, 2020

A dosimetry evaluation model for treatment planning of esophageal radiation therapy is developed using a deep learning model. The model predicts dose volume histogram (DVH) from distance to target vol...

Association between Rheumatoid Arthritis and Apical Periodontitis: A Cross-sectional Study.

Aug 10, 2020

The present cross-sectional study aimed to investigate possible association between Rheumatoid Arthritis (RA) and Apical Periodontitis (AP).In table one it is mentioned 48 patients diagnosed with RA w...

Tofacitinib, an Oral Janus Kinase Inhibitor: Analysis of Malignancy (Excluding Nonmelanoma Skin Cancer) Events Across the Ulcerative Colitis Clinical Program.

Aug 10, 2020

Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Here, we performed an integrated analysis of malignancy events from the tofacitinib phase 3 ...

Cascade Programming for 10 kHz Spinal Cord Stimulation: A Single Center Case Series of 114 Patients With Neuropathic Back and Leg Pain.

Aug 10, 2020

Ten kilohertz spinal cord stimulation (SCS) is usually initiated in a single-bipolar configuration over the radiological reference point T9/T10 intervertebral disc space for neuropathic back and leg...

Opioid-free anesthesia for patients undergoing mastectomy: A matched comparison.

Aug 10, 2020

Opioid-free anesthesia (OFA) is being implemented in breast surgery due to increased awareness of adverse effects and the national opioid crisis. The objective of this study was to examine the effect ...

In utero opioid exposure and risk of infections in childhood: A multinational Nordic cohort study.

Aug 10, 2020

There is an increasing number of children with in utero exposure to opioids. Knowledge about opioid safety in pregnancy, particularly for outcomes later in childhood is scarce. It has been suggested t...

Potentially Inappropriate Medication Combination with Opioids among Older Dental Patients: A Retrospective Review of Insurance Claims Data.

Aug 10, 2020

Opioid prescribing by dentists for older patients receiving medications with potential contraindications and the subsequent impact on acute care outcomes is not well described.Our objective was to eva...

Site V Surgery for Temporal Migraine Headaches.

Aug 10, 2020

Auriculotemporal nerve is demonstrated to contribute to migraine pain in temporal area. In particular, its relationship with the superficial temporal artery in the soft tissues superficial to the temp...

Management of Migraine and the Accessibility of Specialist Care: Findings from an Extended Multinational Survey (My Migraine Center Survey).

Aug 10, 2020

The parent study was a survey in 28 headache centers (6 countries) which identified five potential root causes for long waiting lists that limit patient access to specialist care. Here we performed an...

Migraine Screening in Primary Eye Care Practice: Current Behaviors and the Impact of Clinician Education.

Aug 10, 2020

Migraine is underdiagnosed and undertreated. Optometrists are primary eye care providers, who regularly encounter people with migraine as an incidental finding during routine eye examinations, or when...

The Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) combined with Physical Therapy on Common Musculoskeletal Conditions: A Systematic Review and Meta-Analysis.

Aug 10, 2020

The analgesic effects of transcranial Direct Current Stimulation (tDCS) combined with physical therapy remain unclear.To systematically review available evidence comparing tDCS with any physical thera...

The association between daily physical exercise and pain among women with fibromyalgia: the moderating role of pain catastrophizing.

Aug 10, 2020

Fibromyalgia (FM) is a condition marked by widespread chronic pain and an array of somatic and psychological symptoms. The primary objective of this study was to explore daily associations between phy...

Is fibromyalgia frequency increasing in axial spondyloarthritis? Association with fibromyalgia and biological therapies.

Aug 10, 2020

Fibromyalgia (FM) is known a common painful syndrome and its frequency is increased in inflammatory rheumatic diseases. We aimed to assess FM frequency in axial spondyloarthritis (AxSpA) patients and ...

Prescribing patterns and clinical outcomes of biological disease-modifying anti-rheumatic drugs for rheumatoid arthritis in Spain.

Aug 10, 2020

New treatments in rheumatoid arthritis (RA) have been developed to improve patient outcomes, raise their quality of life, and reduce joint damage, but long-term responses and remission remain low. Thi...

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