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Pain General

Galcanezumab for the prevention of Cluster Headache.

Jul 27, 2020

Cluster headache (CH) is among the worst painful conditions. The available therapies are scarce and not specific, leaving many patients unsatisfied because of poor efficacy and/or tolerability. Patien...

The American College of Rheumatology Fibromyalgia Criteria Are Useful in the Evaluation of Fibromyalgia Symptoms in Patients With Ankylosing Spondylitis: A Cross-Sectional Study.

Jul 27, 2020

Fibromyalgia (FM) is common among patients with ankylosing spondylitis (AS), and its coexistence is believed to interfere with the measurement of patient-reported outcomes of disease activity and func...

Effects of high frequency neuronavigated repetitive transcranial magnetic stimulation in fibromyalgia syndrome: A double-blinded, randomized controlled study.

Jul 27, 2020

The primary aim of the study was to investigate the effect of 10 Hz repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) on pain in fibromyalgia. Seco...

"No one wants to look after the fibro patient". Understanding models, and patient perspectives, of care for fibromyalgia: reviews of current evidence.

Jul 27, 2020

Fibromyalgia is a common and complex long-term pain condition. Despite advancements in our understanding and treatment of fibromyalgia, patients report patchy health care provision and frustrating jou...

Targeted and triple therapy-based liposomes for enhanced treatment of rheumatoid arthritis.

Jul 27, 2020

Rheumatoid arthritis (RA) is an autoimmune disease that is currently incurable. Clinical practice has shown significant benefits of combined therapies for RA treatment. This study aims to develop and ...

A Novel RP-HPLC-DAD Method Development for Anti-Malarial and COVID-19 Hydroxy Chloroquine Sulfate Tablets and Profiling of In-Vitro Dissolution in Multimedia.

Jul 27, 2020

Hydroxychloroquine sulfate is one of a large series of 4-aminoquinolines with antimalarial activity. Moreover, it is used for the treatment of rheumatoid arthritis. Sometimes Hydroxychloroquine sulfat...

Continued Prescribing of Periprocedural Codeine and Tramadol to Children after a Black Box Warning.

Jul 23, 2020

Codeine and tramadol are commonly used analgesics in surgery. In 2013, the Food and Drug Administration (FDA) issued a contraindication to the use of codeine in tonsillectomy and adenoidectomy patient...

The Efficacy and Safety of Transversus Abdominis Plane Blocks After Open Cholecystectomy in Low- and Middle-Income Countries.

Jul 23, 2020

Postoperative pain management is challenging in low- and middle-income countries (LMICs). This study assesses the safety and efficacy of transversus abdominis plane (TAP) blocks as an adjunct for post...

Incidence and Risk Factors for Implant Failure in Spinal Metastasis Surgery.

Jul 23, 2020

Retrospective study.To investigate the incidence of symptomatic and asymptomatic implant failure in spinal metastasis surgery and identify potential risk factors.Surgical stabilization with instrument...

Clinical Implication of Mid-Range Dynamic Instability in Lumbar Degenerative Spondylolisthesis.

Jul 23, 2020

Retrospective evaluation.To determine the prevalence of mid-range dynamic instability in patients with degenerative spondylolisthesis (DS) and to evaluate the clinical implication of mid-range instabi...

The Use of Cement in Hip Arthroplasty: A Contemporary Perspective.

Jul 23, 2020

Notable advances in hip arthroplasty implants and techniques over the past 60 years have yielded excellent survivorship of fully cemented, hybrid, and reverse hybrid total hip replacements as demonstr...

Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes.

Jul 23, 2020

In this study, we investigated the role of macrophage stimulating 1 (Mst1) and the AMPK-Sirt1 signaling pathway in the oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumato...

Acceptance and Commitment Therapy for Primary Headache Sufferers: A Randomized Controlled Trial of Efficacy.

Jul 23, 2020

Prevention of headaches via avoidance of triggers remains the main behavioral treatment suggestion for headache management despite trigger avoidance resulting in increases in potency, lifestyle restri...

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study.

Jul 23, 2020

Cross-sectional observational study.This study aimed to analyze any potential associations of extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents with (1) the intensity of low bac...

Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.

Jul 23, 2020

Mitragynine is the most abundant psychoactive alkaloid derived from the leaves of (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioi...

Evaluation of serum uric levels in migraine.

Jul 23, 2020

In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine).The study included 300 ...

Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study.

Jul 23, 2020

A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease. Evidence suggests that in selected patients, chronic opioids may be a valuable t...

Unusual Brain MRI Findings in Patients Imaged for Headache: a Case Series.

Jul 23, 2020

We describe a series of cases with unusual brain MRI findings in patients who present with headache disorders.Incidental findings in patients imaged for headache include the following: aneurysm, arach...

Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model.

Jul 23, 2020

Fibromyalgia (FM) is one of the most common musculoskeletal pain conditions. Although the aetiology of FM is still unknown, mitochondrial dysfunction and the overproduction of reactive oxygen intermed...

Meniscal Allograft Transplantation After Anterior Cruciate Ligament Reconstruction Can Improve Knee Stability: A Comparison of Medial and Lateral Procedures.

Jul 23, 2020

The purpose of this study was to evaluate the clinical score and stability after meniscal allograft transplantation (MAT) after a previous anterior cruciate ligament (ACL) reconstruction.Medial MAT wo...

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