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Pain General

Pharmacologic interventions for prevention of delirium in hospitalized older people: A meta-analysis.

Jul 20, 2020

To comprehensively assess the effects of pharmacologic interventions for prevention of delirium in hospitalized older people.A systematic review with meta-analysis following Preferred Reporting Items ...

A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-Selective Delta Receptor Agonist, in Healthy Subjects.

Jul 20, 2020

The delta opioid receptor (DOR) has been identified as a therapeutic target for migraine, with DOR agonists exhibiting low abuse potential compared with conventional µ-opioid agonists. TRV250 is a no...

Effect of Headache-Free Days on Disability, Productivity, Quality of Life, and Costs Among Individuals with Migraine.

Jul 20, 2020

The functional impairment associated with migraine can cause physical, emotional, and economic ramifications that can affect occupational, academic, social, and family life. Understanding the relation...

Burden of Illness Among People with Migraine and ≥ 4 Monthly Headache Days While Using Acute and/or Preventive Prescription Medications for Migraine.

Jul 20, 2020

Migraine is a chronic disease that reduces health-related quality of life. Little is known about the burden of migraine in individuals who are potential candidates for preventive treatment with ≥ 4 ...

Validity of fibromyalgia survey questionnaire (2016) assessed by telephone interview and cross-cultural adaptation to Brazilian Portuguese language.

Jul 20, 2020

To verify the validity of the 2016-revised Fibromyalgia Survey Questionnaire (FSQ) by telephone interview compared to self-administration and to produce a valid version of FSQ in Brazilian Portuguese ...

Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection.

Jul 20, 2020

Fibromyalgia is a rheumatologic condition characterized by multiple and chronic body pain, and other typical symptoms such as intense fatigue, anxiety and depression. It is a very complex disease wher...

The Effects of Antepartum Depressive Symptoms on Postcesarean Opioid Consumption.

Jul 20, 2020

 The study aimed to test the hypothesis that higher Edinburgh Postnatal Depression Scale (EPDS) scores are associated with increased pain scores and opioid use during postpartum hospitalization foll...

Study of Double-Targeting Nanoparticles Loaded With MCL-1 siRNA and Dexamethasone for Adjuvant-induced Arthritis Therapy.

Jul 20, 2020

The co-delivery of nanoparticles encapsulating gene therapies and chemotherapeutic drugs can achieve synergistic treatment and reduce side effects in normal tissues relative to the systemic use of sin...

Pop a Pill or Give myself a Shot? Patient perspectives of disease-modifying anti-rheumatic drug (DMARD) choice for rheumatoid arthritis (RA).

Jul 20, 2020

To assess how patients with rheumatoid arthritis (RA) decide whether to add oral disease-modifying anti-rheumatic drugs (DMARDs) versus injectable biologic DMARDs when methotrexate response is inadequ...

Plasma Concentrations of Select Inflammatory Cytokines Predicts Pain Intensity 48 Hours Post-shoulder Muscle Injury.

Jul 20, 2020

The relationship between elevated inflammatory cytokine levels and peak pain intensity following acute musculoskeletal injury has not been fully elucidated in high risk subgroups. Identifying the role...

Predictors of Mucosal and Muscle Pain in Vulvodynia: A Cross-Sectional Analysis from the National Vulvodynia Registry.

Jul 20, 2020

Diagnostic criteria for provoked vestibulodynia (PVD) rely on mucosal pain in the vulvar vestibule, with less emphasis on pain from pelvic floor muscles. It is unknown how psychosocial variables assoc...

miR-483-3p promotes cell proliferation and suppresses apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by targeting IGF-1.

Jul 20, 2020

Accumulating evidence suggests that miR-483-3p is implicated in maintaining biological properties in human cancers. However, its biological roles in rheumatoid arthritis (RA) remain unknown. miR-483-3...

Subsequent neoplasms in childhood cancer survivors.

Jul 20, 2020

The aim of the study was to characterize subsequent neoplasm (SN) (malignant (SMN), benign (BSNs), and non-melanoma skin cancer (NMSC)) treated previously for a childhood solid malignant tumor at the ...

Postpartum NSAID Use and Adverse Outcomes among Women with Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-analysis.

Jul 20, 2020

 This study was aimed to perform a systematic review and meta-analysis of the association between postpartum nonsteroidal anti-inflammatory drug (NSAID) use among women with hypertensive disorders o...

Opioid Use Disorder Is Associated with an Increased Risk of Infection after Total Joint Arthroplasty: A Large Database Study.

Jul 16, 2020

Recent studies have shown that patients with opioid use disorder have impaired immunity. However, few studies with large patient populations have evaluated the risks of surgical site infection (SSI) a...

Study protocol for Long-Term Opioid Therapy in Spine Center Outpatients: The Spinal Pain Opioid Cohort (SPOC).

Jul 16, 2020

Spinal pain is the leading worldwide cause of patient-years lived with chronic pain and disability. While opioids are well documented as an effective short-term pain-relieving medication, more than a ...

The Efficacy and Safety of DFN-15 for the Treatment of Migraine: A Meta-Analysis of Randomized Controlled Studies.

Jul 16, 2020

The efficacy of DFN-15 for pain control of migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of DFN-15 versus placebo on pain control in migrain...

Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight/obesity.

Jul 16, 2020

Pain catastrophizing and cutaneous allodynia represent two risk factors for greater headache-related disability. Yet, there is limited knowledge of the extent to which these risk factors are modifiabl...

Stroke-like migraine attacks after radiation therapy (SMART) syndrome-a case series and review.

Jul 16, 2020

Cranial irradiation is used both prophylactically and for the treatment of brain tumors. There are various complications associated with it. The rare complication of stroke-like migraine attacks after...

Syrian female war refugees: preliminary fibromyalgia and insomnia screening and treatment trends.

Jul 16, 2020

Fibromyalgia (FM) is a chronic disorder characterised by chronic widespread pain, fatigue and sleep disturbances with higher prevalence in females. Psychological factors contribute largely to FM. Alth...

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