Jul 16, 2020

Alterations in cellular energy metabolism have been implicated in chronic pain suggesting a role for mitochondrial DNA (mtDNA). Previous studies reported associations of a limited number of mtDNA poly...

Jul 16, 2020

More than one-fourth of all Persian Gulf War coalition soldiers remain seriously ill. Several epidemiological studies suggest a link between multiple vaccinations at the time of the military operation...

Jul 16, 2020

As a community survey of people living with spinal cord injury in 22 countries, representing all six of WHO regions of the world, InSCI is one of a very few surveys that highlights, not only the basic...

Jul 16, 2020

Cerebrospinal fluid hypovolemia (CSFH) is usually treated via an epidural blood patch (EBP). Accurate placement of the EBP at the site of cerebrospinal fluid (CSF) leakage is required for the successf...

Jul 16, 2020

Anorectal procedures are frequently performed and have the potential to be particularly painful. There are no evidence-based guidelines regarding opioid prescribing after anorectal surgery and limited...

Jul 16, 2020

TNF plays a key role in immune-mediated inflammatory diseases including rheumatoid arthritis (RA) and spondyloarthritis (SpA). It remains incompletely understood how TNF can lead to different disease ...

Jul 16, 2020

Monoclonal antibodies (mAbs) are critically important biologics as the largest class of molecules used to treat cancers, rheumatoid arthritis, and other chronic diseases. Antibody glycosylation is a c...

Jul 16, 2020

Chronic widespread pain conditions are more prevalent in women than men suggesting a role for gonadal hormones in the observed differences. Previously, we showed female mice, compared to male, develop...

Jul 16, 2020

Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compare...

Jul 16, 2020

Offset analgesia (OA), a psychophysical test of endogenous pain inhibition, is diminished in many adult chronic pain disorders but OA has not been investigated in youth with chronic pain disorders. Th...

Jul 16, 2020

The purpose of this study was to determine the rate of short-term complications after TEA and identify predictors of readmission and reoperation. We hypothesized that TEA performed for acute elbow tra...

Jul 13, 2020

Characterize the state of the science in opioid policy research based on a literature review of opioid policy studies.We conducted a scoping review of studies evaluating the impact of U.S. state-level...

Jul 13, 2020

Methamphetamine use, with and without opioids, has increased substantially, but little is known about the sociodemographic characteristics, substance use patterns, or health profiles of individuals wh...

Jul 13, 2020

Hydrocephalus is a chronic medical condition that has a significant impact on children and their caregivers. The objective of this study was to measure the quality of life (QOL) of children with hydro...

Jul 13, 2020

This study sought to determine the prevalence of menstrual migraine among female university students at the Nursing Faculty of Ciudad Real and to determine possible risk factors.A cross-sectional obse...

Jul 13, 2020

Cortical spreading depolarisation (CSD), the neural mechanism underlying migraine aura, may cause headache by sensitising the trigeminal system. Photophobia, the most bothersome accompanying symptom d...

Jul 13, 2020

The association among dysmenorrhea, chronic pain, and conditions classified as central sensitivity syndromes (CSS) is largely unknown. We investigated the co-occurrence of dysmenorrhea with chronic pa...

Jul 13, 2020

Although chronic pain is common in patients with Ehlers-Danlos syndrome (EDS) and hypermobility syndromes (HMS), little is known about the clinical characteristics of these groups. The main aim was to...

Jul 13, 2020

Little is known about opioid and gabapentinoid (OPI-GABA) use duration and dose patterns' associations with adverse outcomes risks. We examined associations between OPI-GABA dose and duration trajecto...

Jul 13, 2020

Limonene (LIM) and its main metabolite perillyl alcohol (POH) are ingredients found in food with promising chemical entities due to their pharmacological profile. In this study, we hypothesized that L...