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Pain General

Exercise interventions for persistent non-specific low back pain - does matching outcomes to treatment targets make a difference? A systematic review and meta-analysis.

Jun 29, 2020

Exercise is a core treatment for persistent non-specific low back pain (NSLBP), but results from randomised controlled trials (RCTs) of exercise typically show only small to moderate standardised mean...

Inter-individual differences in the responses to pain neuroscience education in adults with chronic musculoskeletal pain: A systematic review and meta-analysis of randomised controlled trials.

Jun 29, 2020

Pain neuroscience education (PNE) is an approach used in the management of chronic musculoskeletal pain (CMP). Previous reviews on PNE and other pain interventions, have focussed on mean treatment eff...

Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis.

Jun 29, 2020

Patients with rheumatoid arthritis experience chronic pain, depression and fatigue, even when inflammation of the joints is well controlled. To study the relationship between arthritis, depression, an...

Coccidioidal meningitis in non-AIDS patients. A case series at a Mexican neurological referral center.

Jun 29, 2020

Coccidioidal meningitis is a life-threatening condition and a diagnostic challenge in cases of chronic meningitis. It is associated to severe complications, like basal arachnoiditis, hydrocephalus, an...

Preoperative Opioid Use Predicts Prolonged Postoperative Opioid Use and Inferior Patient Outcomes Following Anterior Cruciate Ligament Reconstruction.

Jun 25, 2020

(1) To determine patient factors associated with prolonged opioid use following Anterior Cruciate Ligament Reconstruction (ACLR) and (2) to evaluate the influence of preoperative opioid use on patient...

Identifying patients with chronic pain who respond to acupuncture: results from an individual patient data meta-analysis.

Jun 25, 2020

In a recent individual patient data meta-analysis, acupuncture was found to be superior to sham and non-sham controls in patients with chronic pain. It has been suggested that a subgroup of patients h...

Neurochemical metabolite alterations of the occipital lobe in migraine without aura by proton magnetic resonance spectroscopy.

Jun 25, 2020

Migraine without aura is the most common type of migraine headache, accounting for about 80% of all migraines. The aim of the present investigation was to determine the neurochemical metabolite altera...

Education Affects Pain in Adults Aged 30-49

Jun 25, 2020

Pain is a major health problem among US adults. Surprisingly little, however, is known about educational disparities in pain, especially among the nonelderly. In this study, we analyze disparities in ...

The role of opioid analgesics in rheumatic disorders: a position paper from the Portuguese Rheumatology Society.

Jun 25, 2020

Pain is a common feature of most rheumatic diseases and it is often the main reason for the patient to seek for a clinical appointment. Chronic pain has a major impact on patient's quality of life, be...

Effects of water- and land-based exercises on quality of life and physical aspects in women with fibromyalgia: A randomized clinical trial.

Jun 25, 2020

Fibromyalgia (FM) is consistently associated with fatigue, sleep disturbances, morning stiffness, and anxiety and depression, affecting physical capacities and skills and thereby reducing quality of l...

Endogenous Opiates and Behavior: 2018.

Jun 25, 2020

This paper is the forty-first consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2018 that studied the...

NMDA receptor modulates spinal iron accumulation via activating DMT1(-)IRE in remifentanil-induced hyperalgesia.

Jun 25, 2020

N-methyl-D-aspartate (NMDA) receptor activation is known to be critical in remifentanil-induced hyperalgesia. Evidence indicates that iron accumulation participates in NMDA neurotoxicity. This study a...

Individualized augmented reality training reduces phantom pain and cortical reorganization in amputees: A proof of concept study.

Jun 25, 2020

Phantom limb pain (PLP) may be relieved using a visual representation of an intact limb. However, patients with distorted (telescoped) phantoms seem unable to associate with visualizations of intact l...

Systematic Review of Research Methods and Reporting Quality of Randomized Clinical Trials of Spinal Cord Stimulation for Pain.

Jun 25, 2020

This systematic review assessed design characteristics and reporting quality of published randomized clinical trials of spinal cord stimulation (SCS) for treatment of pain in adults and adolescents. T...

Comparing central pain processing in individuals with non-traumatic neck pain and healthy individuals: a systematic review and meta-analysis.

Jun 25, 2020

This systematic review and meta-analysis examined the evidence for altered central pain processing in people with non-traumatic neck pain and the relationship between central pain processing, demograp...

Activated antimicrobial peptides due to periodontal bacteria in synovial fluid - The link between psoriatic arthritis and periodontitis?

Jun 25, 2020

The impact of periodontal disease on systemic conditions has not been fully identified yet. Literature shows that the incidence of psoriatic arthritis in psoriasis-patients is higher in presence of pe...

Role of different Th17 and Treg downstream signalling pathways in the pathogenesis of Staphylococcus aureus infection induced septic arthritis in mice.

Jun 25, 2020

Septic arthritis is a condition of bone disorder caused predominantly by Staphylococcus aureus. Following the bacterial entry activated immune cells specially macrophages and dendritic cells release p...

Lower Socioeconomic Status and Co-morbid Conditions are Associated with Reduced CPAP Adherence use Among Older Adult Medicare Beneficiaries with Obstructive Sleep Apnea.

Jun 25, 2020

To examine rates of adherence to continuous positive airway pressure (CPAP) therapy among a representative sample of older adult Medicare beneficiaries with obstructive sleep apnea (OSA), and to ident...

Tolerogenic vaccines for the treatment of cardiovascular diseases.

Jun 25, 2020

Atherosclerosis is the main pathology behind most cardiovascular diseases. It is a chronic inflammatory disease characterized by the formation of lipid-rich plaques in arteries. Atherosclerotic plaque...

A Novel Vestibular Migraine Assessment Tool

Jun 23, 2020

Increasing evidence suggests that vestibular migraine (VM) is a common cause of episodic vertigo, with an estimated 2.7% of US adults having been diagnosed with the condition. “Despite being common,...

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