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Pain General

Headache in children with Sturge-Weber syndrome - Prevalence, associations and impact.

Jun 22, 2020

Sturge-Weber syndrome (SWS) is a congenital neurovascular disorder characterised by capillary-venous malformations involving the skin, brain and eye. Patients experience headache, however little is kn...

The Use of Botulinum Toxin in the Management of Headache Disorders.

Jun 22, 2020

Tremendous progress has been made in the past decades for the treatment of headache disorders. Chronic migraine is the most disabling type of headache and requires the use of acute and preventive medi...

Altered resting-state functional connectivity between subregions in the thalamus and cortex in migraine without aura.

Jun 22, 2020

Migraine is a complex and disabling neurological disorder, and the exact neurological mechanisms remain unclear. Thalamus is considered the hub of the central processing and integration of nociceptive...

Extended overview of the longitudinal pain-depression association: A comparison of six cohorts treated for specific chronic pain conditions.

Jun 22, 2020

The aim was to quantify and to compare the associations between longitudinal changes in pain and depression in different chronic pain conditions.Data were retrieved from 6 observational cohort studies...

DNA methylation and BDNF expression account for symptoms and widespread hyperalgesia in patients with Chronic Fatigue Syndrome and Fibromyalgia.

Jun 22, 2020

Epigenetics of neurotrophic factors holds the potential to unravel the mechanisms underlying the pathophysiology of complex conditions such as chronic fatigue syndrome (CFS). This study explored the ...

Alleviation of TGF-β1 induced tubular epithelial-mesenchymal transition via the δ-opioid receptor.

Jun 22, 2020

Renal fibrosis is a common pathological feature of progressive chronic kidney disease (CKD). It is indicated that transforming growth factor-β1 (TGF-β1) plays as a central mediator in renal fibrosis...

Acute pain after breast surgery and reconstruction: A two-institution study of surgical factors influencing short-term pain outcomes.

Jun 22, 2020

Acute postoperative pain following surgery is known to be associated with chronic pain development and lower quality of life. We sought to analyze the relationship between differing breast cancer exci...

Reconnecting the Brain with the Rest of the Body in Musculoskeletal Pain Research.

Jun 22, 2020

A challenge in understanding chronic musculoskeletal pain is that research is often siloed between neuroscience, physical therapy/rehabilitation, orthopedics and rheumatology which focus respectively ...

Psychosocial predictors of acute and chronic pain in adolescents undergoing major musculoskeletal surgery.

Jun 22, 2020

Acute and chronic pain delay recovery and impair outcomes after major pediatric surgery. Understanding unique risk factors for acute and chronic pain is critical to developing effective treatments for...

Once an avoider always an avoider? Return of pain-related avoidance after extinction with response prevention.

Jun 22, 2020

In exposure for chronic pain, avoidance is often forbidden (extinction with response prevention; RPE) to prevent misattributions of safety. Although exposure is an effective treatment, relapse is comm...

Chronic facial pain: different comorbidities and characteristics between neuropathic and nonneuropathic conditions.

Jun 22, 2020

The aim of this study was to investigate the association between comorbidities and chronic diseases and neuropathic and nonneuropathic orofacial pain diagnoses to suggest subclassifications of disease...

Disorders of the Aorta and Aortic Valve in Connective Tissue Diseases.

Jun 22, 2020

The incidence of aortic valve disease in inherited connective tissue disorders is well documented; however, recent studies have only begun to unravel the pathology behind this association. In this rev...

Translating clinical and patient-reported data to tailored shared decision reports with predictive analytics for knee and hip arthritis.

Jun 22, 2020

New informatics tools can transform evidence-based information to individualized predictive reports to serve shared decisions in clinic. We developed a web-based system to collect patient-reported out...

Septic arthritis of the hip, an unreported complication of perforated appendicitis: A case report.

Jun 22, 2020

Progression of inflammation in acute appendicitis can lead to appendiceal perforation, which is associated with higher morbidity and mortality. Bacteremia due to a perforated appendicitis can lead to ...

Screening and brief intervention for lower-risk drug use in primary care: A pilot randomized trial.

Jun 22, 2020

The efficacy of screening and brief intervention for lower-risk drug use is unknown. This pilot study tested the efficacy of two brief interventions (BIs) for drug use compared to no BI in primary car...

Stress indices in methadone maintenance treatment - Cross sectional and follow up study.

Jun 18, 2020

To study the prevalence of perceived high stress among methadone maintenance treatment (MMT) patients, and whether stress can predict outcome, and whether stress may improve during treatment, we studi...

Transitioning from pharmaceutical opioids: A discrete-time survival analysis of heroin initiation in suburban/exurban communities.

Jun 18, 2020

Research identifying pathways to heroin use has typically been conducted among urban populations. This study examined heroin initiation following pharmaceutical opioid use in three suburban/exurban So...

Candesartan in migraine prevention: results from a retrospective real-world study.

Jun 18, 2020

Randomized studies have reported a positive effect of candesartan, an angiotensin II receptor antagonist, in migraine prevention. The aim of our study was to explore patient subjective efficacy of can...

The Humanistic and Economic Burden of Migraine in Europe: A Cross-Sectional Survey in Five Countries.

Jun 18, 2020

Prior studies have estimated the burden of migraine in patients suffering from ≥ 4 monthly headache days (MHDs), but the burden experienced by migraineurs suffering from one to three (1-3) MHDs i...

Effects of dry needling technique into trigger points of the sternocleidomastoid muscle in migraine headache: A randomized controlled trial.

Jun 18, 2020

The study aimed to investigate the effect of dry needling (DN) into trigger points of the sternocleidomastoid muscle in migraine headache patients.Forty subjects with a migraine headache, originating ...

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