Pain General
May 28, 2020
This randomized, double-blind, Phase 3 study (56-week treatment; 24-week follow-up) assessed tanezumab in patients with chronic low back pain (CLBP) and history of inadequate response to standard-of-c...
May 28, 2020
Abdominal aortic aneurysms affect more than 3% of US older adults.To test whether doxycycline reduces the growth of abdominal aortic aneurysm over 2 years as measured by maximum transverse diameter.Pa...
May 28, 2020
Decapping scavenger enzymes (DcpSs) are important players in mRNA degradation machinery and conserved in eukaryotes. Importantly, human DcpS is the recognized target for spinal muscular atrophy (SMA) ...
May 28, 2020
Low bone mineral density (BMD) is commonly observed in people living with HIV (PLWH), however the cause for this BMD loss remains unclear. Sclerostin, a bone-derived antagonist to the Wnt/β-catenin-p...
May 28, 2020
Nephroblastoma overexpressed protein (NOV/CCN3), the early discovered member of the CCN family, has recently been suggested to be involved in a number of inflammatory processes, including wound healin...
May 26, 2020
Chronic pain is associated with persistent structural and functional changes throughout the neuroaxis, including in the prefrontal cortex (PFC). The PFC is important in the integration of sensory, cog...
May 26, 2020
Understanding the mechanisms that drive transition from acute to chronic pain is essential to identify new therapeutic targets. The importance of endogenous resolution pathways acting as a "brake" to ...
May 26, 2020
The opioid epidemic is a significant public health problem that is associated with overdose and death. The increase in opioid-related problems can largely be attributed to increases in opioid prescrip...
May 26, 2020
Exercise induced hypoalgesia (EIH) can be impaired in patients with chronic pain and may be dependent on exercise type. Factors predictive of EIH are not known. This study aimed to: (1) compare EIH in...
May 26, 2020
Recent years have seen an increase in the adoption of cannabinoid medicines, which have demonstrated effectiveness for the treatment of chronic pain. However, the extent to which frequent cannabis use...
May 26, 2020
Management of proximal tibial fractures is a challenging issue in patients with rheumatoid arthritis (RA). In the present study, we aimed to describe our experience of acute total knee replacement in ...
May 08, 2020
With evidence indicating that overprescription of opioids has contributed to the current opioid epidemic, current Society of Hospital Medicine (SHM) guidelines recommend using the oral route of admini...
May 05, 2020
Research indicates that Chronic migraine (CM; ≥15 monthly headache days with 8 or more linked to migraine) is associated with higher rates of disability and comorbidities, as well as reductions in h...
May 03, 2020
Chronic pain affects an estimated 20% of people worldwide and remains difficult to treat. Although previous studies suggest that altering the central representation of the body through multisensory bo...
Apr 03, 2020
FRIDAY, April 3, 2020 (HealthDay News) -- Legally dispensed marijuana products have stronger concentrations of tetrahydrocannabinol (THC) and cannabidiol (CBD) than needed for chronic pain relief, acc...
Apr 01, 2020
Despite being the most common neurologic cause of vertigo in adults, no FDA-approved treatments are available for vestibular migraine (VM) and few studies have assesses possibly effective rescue treat...
Mar 23, 2020
The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported...
Mar 23, 2020
The method shown in this article simulates spontaneous pain in patients with nociplastic pain using rats; the measurement with this method could be related to better translation of analgesic efficacie...
Mar 23, 2020
The objective of the present manuscript was to evaluate the effects of 24-weeks exergame intervention on the heart rate variability (HRV) of women with fibromyalgia. First, 56 women with fibromyalgia ...
Mar 23, 2020
Individuals with pain report higher sensory disturbances during sensorimotor conflicts compared to pain-free individuals. In the pain field, it is frequently assumed that disturbances arise from a dis...