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Pain General

Efficacy and safety of immediate oral intake in patients with mild acute pancreatitis: A randomized controlled trial.

Mar 23, 2020

Early enteral nutrition is recommended for patients with severe acute pancreatitis (AP); however, nutritional management strategies for patients with mild AP have not been established. The aim of this...

A Comprehensive Review of Over-the-counter Treatment for Chronic Migraine Headaches.

Mar 23, 2020

Migraine headaches are a neurologic disorder characterized by attacks of moderate to severe throbbing headache that are typically unilateral, exacerbated by physical activity, and associated with phon...

FERM domain-containing protein 6 identifies a subpopulation of varicose nerve fibers in different vertebrate species.

Mar 23, 2020

FERM domain-containing protein 6 (FRMD6) is a member of the FERM protein superfamily, which is evolutionary highly conserved and has recently been identified as an upstream regulator of the conserved ...

Contactless treatment for scoliosis by electromagnetically controlled shape-memory alloy rods: a preliminary study in rabbits.

Mar 23, 2020

To evaluate the safety and efficacy of a system aiming to correct scoliosis called "electromagnetically controlled shape-memory alloy rods" (EC-SMAR) used in a rabbit model.We heat-treated shape-memor...

Changes in sales of analgesics to pharmacies after codeine was rescheduled as a prescription only medicine.

Mar 23, 2020

To investigate changes in sales to pharmacies of over-the-counter (OTC) and prescription analgesics, cold and flu products, and cough suppressants after the rescheduling of codeine as a prescription o...

Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report.

Mar 23, 2020

Psoriasis is the most common chronic inflammatory condition involving the T helper cell system. Population studies have demonstrated that patients with psoriasis and/or psoriatic arthritis have an inc...

The microbiome and rheumatoid arthritis.

Mar 23, 2020

Rheumatoid Arthritis (RA) is a severe, chronic autoimmune disease that affects 1% of the world's population. Familial risk contributes 50% of the risk of seropositive RA, with strongest risks seen in ...

Challenges in the clinical diagnosis of psoriatic arthritis.

Mar 23, 2020

Psoriatic arthritis (PsA) is a chronic heterogeneous inflammatory musculoskeletal disease. The non-specific and often subtle manifestations make early diagnosis and subsequent treatment challenging. I...

Effectiveness of the use of an algorithm in the diagnostic approach of joint pain patients by primary care physicians.

Mar 23, 2020

There is a high percentage of error in the approach of patients with joint pain by primary care physicians. An algorithm can help improve this misdiagnosis problem. Our study seeks to determine the ef...

Treatment of chronic neuropathic pain: purine receptor modulation.

Mar 23, 2020

Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses four G protein-coupled receptors (GPCRs) for adenosine, eight GPCR...

Are weather conditions associated with chronic musculoskeletal pain? Review of results and methodologies.

Mar 23, 2020

Many people believe that weather influences chronic musculoskeletal pain. Previous studies on this association are narratively reviewed, with particular focus on comparing methodologies and summarisin...

Nicotinamide adenine dinucleotide phosphate oxidase 2-derived reactive oxygen species contribute to long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn and persistent mirror-image pain following high-frequency stimulus of the sciatic nerve.

Mar 23, 2020

High-frequency stimulation (HFS) of the sciatic nerve has been reported to produce long-term potentiation (LTP) and long-lasting pain hypersensitivity in rats. However, the central underlying mechanis...

Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study.

Mar 23, 2020

Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal ...

Pharmacological target-focused transcriptomic analysis of native versus cultured human and mouse dorsal root ganglia.

Mar 23, 2020

Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain processing. They are often studied in vitro as dissociated cell cultures with the assumption that this reasonably repr...

Influence of estradiol treatment on bone marrow cell differentiation in collagenase-induced arthritis.

Mar 23, 2020

Estrogen is one of the important regulators of the balance between bone formation and bone resorption that can modulate the levels and activity of certain growth factors and cytokines. In this study, ...

Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.

Mar 23, 2020

We aimed to assess the association between migraine headache and incident dementia.Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with incre...

Joint trajectories of disease activity, and physical and mental health-related quality of life in an inception lupus cohort.

Mar 20, 2020

To examine for latent patterns of SLE disease activity trajectories that associate with specific latent patterns of health-related quality of life (HRQoL; Medical Outcomes Study Short Form-36), and to...

Barbecue grill brush bristles found in odd places

Mar 18, 2020

With spring almost here, it’s time to start barbecuing again. It may be one of our few diversions if we are still staying home. Before you get out that wire brush to clean off last year’s grill me...

Buprenorphine Treatment for Opioid Use Disorder in Community-Based Settings: Outcome Related to Intensity of Services and Urine Drug Test Results.

Mar 13, 2020

Variables contributing to the outcome of buprenorphine treatment for opiate use disorder have been studied, including patient characteristics and the treatment approach applied. It is also valuable to...

A TREK Channel Family Activator with Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation.

Mar 13, 2020

TWIK-related K+ (TREK) channels are potential analgesic targets. However, selective activators for TREK with both defined action mechanism and analgesic ability for chronic pain have been lacking. Her...

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