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Sleep Disorders

Motivation and sensitivity to monetary reward in late-life insomnia: moderating role of sex and the inflammatory marker CRP.

Jun 18, 2020

Insomnia is a well-established risk factor for late-life depression, yet the intermediary mechanisms are not known. One plausible mechanism is dysregulation of the reward system, a common feature of d...

Absorption, Distribution, Metabolism, Excretion (ADME), Drug-drug interaction potential and Prediction of Human Pharmacokinetics of SUVN-G3031, a Novel Histamine 3 Receptor (HR) inverse agonist in Clinical development for the treatment of Narcolepsy.

Jun 15, 2020

SUVN-G3031 is a potent and selective inverse agonist of Histmine-3 (H) receptor that is being investigated for the treatment of narcolepsy. SUVN-G3031 has high passive permeability, not a substrate fo...

Continuous positive airway pressure versus mandibular advancement device in the treatment of obstructive sleep apnea: a systematic review and meta-analysis.

Jun 15, 2020

The goal of this study was to review relevant randomized controlled trials in order to determine the efficacy of continuous positive airway pressure (CPAP) versus mandibular advancement device (MAD) i...

A case of Madelung's disease presenting with obstructive sleep apnea.

Jun 11, 2020

Madelung's disease is a rare condition characterized by diffuse, multiple, symmetric, non-encapsulated, fatty accumulation predominantly in neck and upper trunk which can predispose to obstructive sle...

Performance of peripheral arterial tonometry based testing for the diagnosis of obstructive sleep apnea in a large sleep clinic cohort.

Jun 11, 2020

Peripheral arterial tonometry (PAT) based technology represents a validated portable monitoring modality for diagnosis of obstructive sleep apnea (OSA). We assessed the diagnostic accuracy of PAT-base...

Treatment of somatic symptom disorder in childhood: evidence-based psychotherapy interventions

Jun 11, 2020

About 25-30% of patients present themselves in general practice and specialized healthcare with medically unexplained somatic symptoms. The prevalence of these symptoms is the highest among the elderl...

Sleep surgery in syndromic and neurologically impaired children.

Jun 08, 2020

To examine surgery performed for obstructive sleep apnea (OSA) in children with syndromic or neurologic comorbidities.Medical records of 375 children with OSA were retrospectively reviewed, including ...

Everyday and major experiences of racial/ethnic discrimination and sleep health in a multiethnic population of U.S. women: findings from the Sister Study.

Jun 08, 2020

Perceived racial/ethnic discrimination and poor sleep occur across all races/ethnicities in the U.S., although both are most common among racial/ethnic minorities. Few studies have investigated associ...

Effect of treatment on cognitive and attention problems in children with narcolepsy type 1.

Jun 08, 2020

To ascertain the presence of cognitive and attention problems in treatment naïve children with narcolepsy type 1 (NT1) and to explore whether children recently diagnosed with NT1 improve with respect...

Obstructive sleep apnea caused by acromegaly: Case report.

Jun 04, 2020

Acromegaly is an uncommon syndrome caused by growth hormone-producing pituitary adenoma or pituitary gland hypertrophy. Acromegaly is known to be characterized by progressive somatic disfigurement and...

Benzodiazepine use before conception and risk of ectopic pregnancy.

Jun 04, 2020

Are women who fill a benzodiazepine prescription before conception at increased risk of ectopic pregnancy?Risk of ectopic pregnancy is 50% higher among women who fill a benzodiazepine prescription bef...

A Modified Cosmetic Genioplasty Can Affect Airway Space Positively in Skeletal Class II Patients: Studying Alterations of Hyoid Bone Position and Posterior Airway Space.

Jun 01, 2020

Improving the posterior airway space is one of the most important functions of genioplasty. Studies have shown that the posterior airway space (PAS) can play an important role in the evaluation of obs...

Variation in Sleep Stability with Differences in Severity of Sleep-Disordered Breathing in Children.

Jun 01, 2020

The aim of this study was to analyze the association between obstructive sleep apnea (OSA) severity and various cardiopulmonary coupling (CPC) parameters in children with OSA.Retrospective cross-secti...

Association Between Breathing Route, Oxygen Desaturation, and Upper Airway Morphology.

Jun 01, 2020

This study aimed to assess the role of capnography in objectively evaluating breathing routes during drug-induced sleep endoscopy (DISE) and further elucidate the relationship between breathing route,...

A brief sleep focused psychoeducation program for sleep-related outcomes in new mothers: A randomised controlled trial.

May 28, 2020

Poor sleep is commonly problematic during pregnancy and postpartum and is associated with depression. This trial investigated the efficacy of prenatal brief, group sleep psychoeducation in improving p...

Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS.

May 28, 2020

The present study was planned to examine the relationships between obstructive sleep apnea syndrome (OSAS) and the newly revealed adipokines adropin and adiponectin concentrations that display signifi...

Sex-Specific Impact of Pain Severity, Insomnia, and Psychosocial Factors on Disability due to Spinal Degenerative Disease.

May 28, 2020

Pain experience due to spinal degenerative disease decreases activity of daily living and quality of life. The present cross-sectional study was aimed at examining the sex-specific impact of pain seve...

Managing Insomnia Using Lucid Dreaming Training: A Pilot Study.

Mar 13, 2020

: Despite Cognitive Behavioral Therapy for Insomnia (CBT-I) being considered the first-line treatment for insomnia, it is not without its challenges. As such it is worthwhile to consider, and test, al...

Orexin in Respiratory and Autonomic Regulation, Health and Diseases.

Mar 13, 2020

Orexin neurons, located in the hypothalamus, produce orexin-A and orexin-B neuropeptides and send widespread projections throughout the central nervous system, including many nuclei that are criticall...

Behavioral Interventions for Sleep Disturbances in Children with Neurological and Neurodevelopmental Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Mar 13, 2020

Sleep disturbances are common and associated with negative functional and health consequences in children with neurological and neurodevelopmental disorders (NNDDs), and represent an important potenti...

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