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Sleep Disorders

Gender differences in plasma pharmacokinetics and hepatic metabolism of geissoschizine methyl ether from Uncaria hook in rats.

Sep 10, 2020

Geissoschizine methyl ether (GM), an indole alkaloid from Uncaria hook, is an active ingredient in the traditional Japanese Kampo medicine yokukansan, which is used to treat neurosis, insomnia, irrita...

Short communication: Self-reported sleep-wake disturbances preceding onset of full-threshold mood and/or psychotic syndromes in community residing adolescents and young adults.

Sep 10, 2020

Insomnia may predict onset of mental disorders in adults. However, it is unclear whether the same directional relationship exists during the peak age range for the onset of major mental disorders and/...

Management of obstructive sleep apnea in children with achondroplasia: Outcomes of surgical interventions.

Sep 10, 2020

Children with achondroplasia are predisposed to obstructive sleep apnea (OSA), however little is known regarding surgical interventions and outcomes for this condition. The aim of this study was to ev...

Does gender matter: sex-specific aspects of symptoms, outcome, and therapy of obstructive sleep apnea.

Sep 07, 2020

Obstructive sleep apnea (OSA) has historically been considered as a male disease. As a result, female individuals with OSA were often under-diagnosed and under-treated compared with male individuals. ...

Acute intermittent hypercapnic hypoxia and cerebral neurovascular coupling in males and females.

Sep 07, 2020

The decline in cognition observed in obstructive sleep apnea is linked to intermittent hypercapnic hypoxia (IHH), which is known to impair cerebrovascular reactivity. Whether acute IHH impairs the mat...

Association between concurrent antidepressant and hypnotic treatment and the risk of dementia: A nationwide cohort study.

Sep 07, 2020

This study aimed to investigate the risk of dementia among subgroups of patients receiving concurrent antidepressant and hypnotic treatment, antidepressants alone, and hypnotics alone.Multivariate Cox...

Efficacy and long-term follow-up of positional therapy by vibrotactile neck-based device in the management of positional OSA.

Sep 03, 2020

Different therapeutic strategies have been investigated for the treatment of positional-OSA (POSA), but more evidence is needed about efficacy and compliance. The objective of this study was to descri...

Obstructive sleep apnea and respiratory center regulation abnormality.

Sep 03, 2020

Obstructive sleep apnea (OSA) is a complex disease in which phenotypic analysis and understanding pathological mechanisms facilitate personalized treatment and outcomes. However, the pathophysiology r...

Mental health during the COVID-19 pandemic: Effects of stay-at-home policies, social distancing behavior, and social resources.

Aug 31, 2020

Social distancing is the most visible public health response to the COVID-19 pandemic, but its implications for mental health are unknown. In a nationwide online sample of 435 U.S. adults, conducted ...

Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness.

Aug 31, 2020

As nocturnal hypoxemia and heart rate variability are associated with excessive daytime sleepiness (EDS) related to OSA, we hypothesize that the power spectral densities (PSD) of nocturnal pulse oxime...

Alterations in sympathetic and parasympathetic brain networks in obstructive sleep apnea.

Aug 24, 2020

Obstructive sleep apnea (OSA) patients experience hypoxia and, potentially, autonomic impairments stemming from neural damage. In this study, the executive control networks (ECNs), salience networks (...

Cardiovascular changes in children with obstructive sleep apnea and obesity after treatment with non-invasive ventilation.

Aug 20, 2020

Adults with obesity and obstructive sleep apnea (OSA) are at risk for cardiometabolic disease and this risk likely extends to children with both conditions. Non-invasive ventilation (NIV; including co...

Prevalence and Correlates of Mental Health Problems in Norwegian Peacekeepers 18-38 Years Postdeployment.

Aug 20, 2020

Peacekeeping missions involve experiences that may impact the mental health of participating soldiers. However, research on the long-term mental health consequences of peacekeeping is sparse. The pres...

Insomnia as a mediating therapeutic target for depressive symptoms: A sub-analysis of participant data from two large randomized controlled trials of a digital sleep intervention.

Aug 20, 2020

Insomnia predicts the onset of depression, commonly co-presents with depression and often persists following depression remission. However, these conditions can be challenging to treat concurrently us...

Physical Exercise and Fitness Level Are Related to Cognitive and Psychosocial Functioning in Adolescents.

Aug 17, 2020

The purpose of this study was to analyze the relationships among physical exercise and fitness with selective attention, concentration, processing speed, general self-efficacy, self-rated health, and ...

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression.

Aug 17, 2020

Obstructive sleep apnea syndrome (OSAS) is considered a low-grade chronic inflammatory disease. Interleukin-6 (IL-6) is one of the most significant inflammatory markers and an excellent proxy for the ...

Effect of back-up head-elevated position during drug-induced sleep endoscopy in obstructive sleep apnea patients.

Aug 17, 2020

This study aimed to evaluate the difference of upper airway collapse between the back-up head-elevated position (a 45° upward inclination) and supine position to better elucidate the role of back-up ...

Effects of trazodone versus cognitive behavioral therapy in the insomnia with short sleep duration phenotype: a preliminary study.

Aug 13, 2020

The insomnia with objective short sleep duration (ISS) phenotype, is associated with increased risk for adverse health outcomes, physiological hyperarousal, and a blunted response to Cognitive-Behavio...

Clinical utility of oximetric parameters to identify a high-risk phenotype of moderate-severe Obstructive Sleep Apnea (OSA).

Aug 13, 2020

It is unclear if oximetric parameters, such as total time of SpO <90%, (T90), oxygen desaturation index-3% (ODI), minimum SpO , are able to describe a high-risk subtype of cardiovascular (CV) c...

Prevalence of Obstructive Sleep Apnea Risk According to the STOP-BANG Questionnaire in an Oral Surgery Office-Based Anesthesia Patient Population.

Aug 13, 2020

Patients with obstructive sleep apnea (OSA) are at an increased risk for perioperative and postoperative complications after receiving intravenous (IV) sedation or postoperative analgesia. We previous...

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