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DSM-5

The prevalence of confirmed childhood trauma and its' impact on psychotic-like experiences in a sample of Chinese adolescents.

Mar 24, 2020

Adolescents with childhood trauma may be associated with psychotic-like experiences (PLEs) and is at high risk for later development of psychoses. Exploring early age risk factors for childhood trauma...

Improving social functioning in community-dwelling patients with schizophrenia: a randomized controlled computer cognitive remediation therapy trial with six months follow-up.

Mar 24, 2020

Computerized cognitive remediation therapy (CCRT) has been found to generally improve cognition among patients with schizophrenia, but its effect on functioning has not been extensively studied. This ...

Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice.

Mar 24, 2020

Methamphetamine (METH) has been reported to induce endoplasmic reticulum (ER) stress and neuronal apoptosis in the central nervous system (CNS) during the development of addiction. Thioredoxin-1 (Trx-...

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress.

Mar 24, 2020

Depression is a common disease that afflicts one in 6 people. Numerous hypotheses have been raised in the past decades, but the exact mechanism for depression onset remains obscure. Recently, the neur...

The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration.

Mar 19, 2020

Vulnerability to drug addiction relies on substantial individual differences. We previously demonstrated that serotonin transporter knockout (SERT ) rats show increased cocaine intake and develop sign...

Distortion-Free Sensing of Neural Activity Using Graphene Transistors.

Mar 19, 2020

Graphene solution-gated field-effect transistors (g-SGFETs) are promising sensing devices to transduce electrochemical potential signals in an electrolyte bath. However, distortion mechanisms in g-SGF...

Early brain abnormalities in infants born very preterm predict under-reactive temperament.

Mar 13, 2020

Early temperament may mediate the association between brain abnormalities following preterm birth and neurodevelopmental outcomes.This exploratory study investigated whether brain abnormalities in inf...

Trends in prevalence and treatment of depressive symptoms in adult patients with epilepsy in the United States.

Mar 13, 2020

Depressive symptoms are a common comorbidity among adults with epilepsy (AWE). Prior estimates regarding prevalence and treatment of depressive symptoms in AWE have been largely based on samples of te...

Dynamic Recovery from Depression Enables Rate Encoding in Inhibitory Synapses.

Mar 13, 2020

Parvalbumin-expressing fast-spiking interneurons (PV-INs) control network firing and the gain of cortical response to sensory stimulation. Crucial for these functions, PV-INs can sustain high-frequenc...

A novel insight into the potential toxicity mechanisms of Zhi-Zi-Hou-Po decoction by dynamic urinary metabolomics based on UHPLC-Q-Exactive Orbitrap-MS.

Mar 13, 2020

In recent years, depression occurs frequently. Given the long duration of the disease and the high risk of recurrence, the treatment of depression requires long-term medication. Zhi-Zi-Hou-Po Decoctio...

Pregnant Women With Depression More Likely to Use Cannabis

Mar 12, 2020

THURSDAY, March 12, 2020 (HealthDay News) -- Women with depression are more than three times more likely to use cannabis during pregnancy compared with women without depression, according to a study p...

[Autism, depression and risk of suicide].

Mar 10, 2020

Autism is a neurodevelopmental disorder characterized by a qualitative alteration in social interaction and communication, associated with restricted interests and stereotyped behaviors. People with a...

[From autism spectrum to autism constellation].

Mar 10, 2020

Research on autism and mental disorders has been unsuccessful over the past few decades, as can be inferred from the poor results related to advances in other diseases. It is concerning that, after mo...

The moderating role of flexible goal adjustment in the link between pain and depressive symptoms: findings based on a nationally representative sample of older adults.

Mar 05, 2020

Pain is a frequent phenomenon in old age. It has been shown that increases in pain are longitudinally associated with depressive symptoms. This strong link can be attenuated by coping strategies like ...

Substance use disorders before, at and after first episode psychosis hospitalizations in a young national Swedish cohort.

Mar 02, 2020

Comorbidity between Substance use disorders (SUD) and psychotic disorders is common but the temporal relation of the first episodes of SUD and psychosis and how it affects the disorders has not been e...

Removal of sulfadiazine and ciprofloxacin by clays and manganese oxides: Coupled sorption-oxidation kinetic model.

Mar 02, 2020

Sorption onto clays (montmorillonite and kaolinite), oxidation and sorption by manganese oxides (synthesized MnO and natural MnO), and coupled sorption-oxidation experiments were conducted for the rem...

Trajectories and mental health-related predictors of perceived discrimination and stigma among homeless adults with mental illness.

Feb 28, 2020

Stigma and discrimination toward individuals experiencing homelessness and mental disorders remain pervasive across societies. However, there are few longitudinal studies of stigma and discrimination ...

Organization of primate amygdalar-thalamic pathways for emotions.

Feb 28, 2020

Studies on the thalamus have mostly focused on sensory relay nuclei, but the organization of pathways associated with emotions is not well understood. We addressed this issue by testing the hypothesis...

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin.

Feb 25, 2020

Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1)....

The power of the Functional Activities Questionnaire for screening dementia in rural-dwelling older adults at high-risk of cognitive impairment.

Feb 25, 2020

A simple approach to detecting dementia in its early stages may help improve patient care. We therefore aimed to assess the power of the Functional Activities Questionnaire (FAQ) for screening dementi...

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