Nov 16, 2020

Ketamine is a potential rapid-acting treatment for depression. Studies have suggested that the side effects are minimal and temporary, but the psychotic symptom side effects have yet to be fully exami...

Nov 16, 2020

Substance use disorder (SUD) is associated with a high risk of physical and mental illness such as anxiety, depression, personality disorders, eating disorders, and abnormal mood changes. During the p...

Nov 16, 2020

Trauma evaluation in the emergency department (ED) can be a stressful event for children. With the goal of minimizing pain, anxiety, and unneeded interventions in stable patients, we implemented the P...

Nov 16, 2020

Nucleosomes cluster together when chromatin folds in the cell to form heterogeneous groups termed "clutches". These structural units add another level of chromatin regulation, for example during cell ...

Nov 16, 2020

Metformin has been recommended as a first-line antidiabetic drug (ADD) for all patients with type 2 diabetes even in the presence of high cardiovascular (CV) risk by American Diabetes Association. In ...

Nov 16, 2020

Family caregivers of a loved one with a life-limiting or terminal illness are often overwhelmed by, and underprepared for, their responsibilities. They often need help from family members and friends ...

Nov 16, 2020

Mild cognitive impairment (MCI) is cognitive decline which can be observed in a wide range of cognitive domains. It is considered as a prodromal stage of dementia; therefore, strategies for treatment ...

Nov 16, 2020

Chronic opioid use and polypharmacy are commonly seen in chronic pain patients presenting for spine procedures. Substance abuse and misuse have also been reported in this patient population. Negative ...

Nov 16, 2020

There is paucity of data on the impact of surgical incision and analgesia on relevant outcomes.A retrospective STROBE-compliant cohort study was performed between July 2007 and August 2017 of patients...

Nov 16, 2020

To estimate the minimum dose and total sedation time of rapidly infused ketamine that achieves 3 to 5 minutes of effective sedation in children undergoing abscess incision and drainage in the emergenc...

Nov 16, 2020

With the incidence of mental disorders increasing, it is essential to understand the neurodevelopmental trajectory of psychiatric symptoms. This study aims to evaluate whether the strength of cooling ...

Nov 16, 2020

Several magnetic resonance imaging (MRI) findings suggest the role of cortical connectivity treatments in the treatment and selectivity for major depressive disorder (MDD). However, its clinical utili...

Nov 16, 2020

Anxiety is a common symptom in young individuals with autism spectrum disorder (ASD). Though psychological therapies for treating anxiety have been proposed, their efficacy has not been established. T...

Nov 16, 2020

With the opioid crisis continually increasing, it is crucial to understand the biological and biochemical mechanisms of opioid abuse. This study aims to identify the genetic risk variants for opioid u...

Nov 16, 2020

Various therapies have been recognized as adjuncts to pharmacotherapy for bipolar disorder patients. However, their efficacy has not been well studied. This study aims to evaluate how using manualized...

Nov 16, 2020

Several observational studies have highlighted the associations between C-reactive protein and interleukin, a cytokine-stimulating substance that induces depressive symptoms. However, whether inflamma...

Nov 12, 2020

In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pai...

Nov 12, 2020

The purpose of this study is to investigate the association between online sexual solicitation (OSS) and internet accessibility, usage, and addiction in adolescents. The study was conducted with 48 ad...

Nov 12, 2020

During the first 6-months of the COVID-19 pandemic, the primary weapons against the spread of the virus have included local government orders for restriction of movement and broad implementation of fa...

Nov 12, 2020

Dysfunction of cholinergic system plays an important role in disease associated with cognitive blockage, such as Alzheimer's disease (AD). Central administration of scopolamine, an antagonist of acety...