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Psychiatry General

Acyl-Carnitine plasma levels and their association with metabolic syndrome in individuals with schizophrenia.

Sep 28, 2020

The metabolic syndrome (MetS) affects individuals with schizophrenia at a higher rate when compared to individuals in the general population. Accumulating evidence indicated that subjects with MetS ge...

Psychiatric emergency care during Coronavirus 2019 (COVID 19) pandemic lockdown: results from a Department of Mental Health and Addiction of northern Italy.

Sep 28, 2020

The current COVID-19 pandemic and the consequent containment measures are leading to increasing mental health issues both in psychiatric patients and general population.We aimed to compare the number ...

Older People's Non-Physical Contacts and Depression During the COVID-19 Lockdown.

Sep 28, 2020

With the goal of slowing down the spread of the Sars-CoV-2 virus, restrictions to physical contacts have been taken in many countries. We examine to what extent intergenerational and other types of no...

Lack of APOE Christchurch variant in five age of onset outliers with PSEN1, PSEN2 Alzheimer's disease and MAPT frontotemporal dementia.

Sep 28, 2020

Age of onset modifiers are of considerable importance in Alzheimer's and related dementias. Arboleda-Valesquez et al., reporting on a single PSEN1 subject, suggested that homozygosity for the Christch...

The neutrophil-to-lymphocyte ratio in Alzheimer's disease: Current understanding and potential applications.

Sep 28, 2020

Alzheimer's disease (AD) is a chronic neurodegenerative disorder affecting millions of people, and its prevalence is expected to continue to grow in the older age population. It is characterized by co...

Anti-amnesic and neuroprotective effects of Fluoroethylnormemantine (FENM) in a pharmacological mouse model of Alzheimer's disease.

Sep 28, 2020

Current therapies in Alzheimer's disease (AD), including Memantine, have proven to be only symptomatic but not curative nor disease-modifying. Fluoroethylnormemantine (FENM) is a structural analogue o...

Bipolarity in a Collaborative Care Model Variation: Detection, Prevalence, and Outcomes.

Sep 28, 2020

To assess the prevalence of bipolarity and its impact on clinical course, psychiatric consultants' diagnostic impressions and respective treatment outcomes were examined for patients with depression w...

The role of vitamin D in bipolar disorder: Epidemiology and influence on disease activity.

Sep 28, 2020

Although many studies found an association between psychiatric disorders, especially major depressive disorder, and vitamin D deficiency, little is still known about the association between vitamin D ...

Seizure threshold manipulation in electroconvulsive therapy via repetitive transcranial magnetic stimulation. A novel way of augmentation?

Sep 28, 2020

A high seizure threshold (ST) is an impeding factor in certain patients, potentially preventing a successful electroconvulsive therapy (ECT) treatment. Several pharmacological and non-pharmacological ...

Technical and radiographic considerations for magnetic resonance imaging-guided focused ultrasound capsulotomy.

Sep 28, 2020

Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is an emerging treatment modality that enables incisionless ablative neurosurgical procedures. Bilateral MRgFUS capsulotomy has recently b...

Opening the curtains for better sleep in psychotic disorders - considerations for improving sleep treatment.

Sep 28, 2020

Sleep disturbances are prevalent in people with psychosis and are related to several negative outcomes. Recent research indicates that sleep disturbances contribute to the development of psychosis and...

Pain or No Pain, We Will Give You Opioids: Relationship Between Number of Opioid Pills Prescribed and Severity of Pain after Operation in US vs Non-US Patients.

Sep 28, 2020

Patients in the US receive disproportionally higher amounts of opioids following surgery compared to their non-US counterparts. We aimed to assess the relationship between perceived pain severity afte...

A non-opioid analgesic implant for sustained post-operative intraperitoneal delivery of lidocaine, characterized using an ovine model.

Sep 28, 2020

Appropriate management of post-operative pain is an ongoing challenge in surgical practice. At present, systemic opioid administration is routinely used for analgesia in the post-operative setting. Ho...

Long term pre-treatment opioid use trajectories in relation to opioid agonist therapy outcomes among people who use drugs in a Canadian setting.

Sep 28, 2020

Opioid agonist therapy (OAT) models are generally provided without consideration of how pre-treatment characteristics may be associated with outcome. Therefore, we aimed to first characterize longitud...

Three multispectral configurations of a snapshot kaleidoscope-based camera in long wavelength infrared spectral band.

Sep 28, 2020

In the field of spectral imaging, numerous instruments use scanning-based technologies. However, the temporal dimension of these systems, whether to scan the spectrum or scan the scene, can be an issu...

Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch Syndrome fibroblasts.

Sep 28, 2020

Recently, mutations in the RNA polymerase III subunit A (POLR3A) have been described as the cause of the neonatal progeria or Wiedemann-Rautenstrauch syndrome (WRS). POLR3A has important roles in tran...

Role of Neuropeptide S on behavioural and neurochemical changes of an animal model of attention-deficit/hyperactivity disorder.

Sep 28, 2020

Neuropeptide S is a recently discovered peptide signaling through its receptor NPSR, which is expressed throughout the brain. Since NPSR activation increases dopaminergic transmission, we now tested i...

Spinal cord injury in the United States Army Special Forces.

Sep 28, 2020

Spinal cord injury (SCI) is an area of key interest in military medicine but has not been studied among the US Army Special Forces (SF), the most elite group of US soldiers. SF soldiers make up a disp...

Anxiety in social interactions and nicotine dependence in nicotine-dependent men: The role of metacognitions about smoking.

Sep 28, 2020

Anxiety in social interactions is an important factor in cigarette use and nicotine dependence. Metacognitions about smoking have been found to predict smoking behavior and may help understand the rel...

A potential biomarker for treatment stratification in psychosis: evaluation of an [F] FDOPA PET imaging approach.

Sep 24, 2020

[F]FDOPA PET imaging has shown dopaminergic function indexed as K differs between antipsychotic treatment responders and non-responders. However, the theragnostic potential of this biomarker to identi...

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