Sep 28, 2020

Current therapies in Alzheimer's disease (AD), including Memantine, have proven to be only symptomatic but not curative nor disease-modifying. Fluoroethylnormemantine (FENM) is a structural analogue o...

Sep 28, 2020

To assess the prevalence of bipolarity and its impact on clinical course, psychiatric consultants' diagnostic impressions and respective treatment outcomes were examined for patients with depression w...

Sep 28, 2020

Although many studies found an association between psychiatric disorders, especially major depressive disorder, and vitamin D deficiency, little is still known about the association between vitamin D ...

Sep 28, 2020

A high seizure threshold (ST) is an impeding factor in certain patients, potentially preventing a successful electroconvulsive therapy (ECT) treatment. Several pharmacological and non-pharmacological ...

Sep 28, 2020

Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is an emerging treatment modality that enables incisionless ablative neurosurgical procedures. Bilateral MRgFUS capsulotomy has recently b...

Sep 28, 2020

Sleep disturbances are prevalent in people with psychosis and are related to several negative outcomes. Recent research indicates that sleep disturbances contribute to the development of psychosis and...

Sep 28, 2020

Patients in the US receive disproportionally higher amounts of opioids following surgery compared to their non-US counterparts. We aimed to assess the relationship between perceived pain severity afte...

Sep 28, 2020

Appropriate management of post-operative pain is an ongoing challenge in surgical practice. At present, systemic opioid administration is routinely used for analgesia in the post-operative setting. Ho...

Sep 28, 2020

Opioid agonist therapy (OAT) models are generally provided without consideration of how pre-treatment characteristics may be associated with outcome. Therefore, we aimed to first characterize longitud...

Sep 28, 2020

In the field of spectral imaging, numerous instruments use scanning-based technologies. However, the temporal dimension of these systems, whether to scan the spectrum or scan the scene, can be an issu...

Sep 28, 2020

Recently, mutations in the RNA polymerase III subunit A (POLR3A) have been described as the cause of the neonatal progeria or Wiedemann-Rautenstrauch syndrome (WRS). POLR3A has important roles in tran...

Sep 28, 2020

Neuropeptide S is a recently discovered peptide signaling through its receptor NPSR, which is expressed throughout the brain. Since NPSR activation increases dopaminergic transmission, we now tested i...

Sep 28, 2020

Spinal cord injury (SCI) is an area of key interest in military medicine but has not been studied among the US Army Special Forces (SF), the most elite group of US soldiers. SF soldiers make up a disp...

Sep 28, 2020

Anxiety in social interactions is an important factor in cigarette use and nicotine dependence. Metacognitions about smoking have been found to predict smoking behavior and may help understand the rel...

Sep 24, 2020

[F]FDOPA PET imaging has shown dopaminergic function indexed as K differs between antipsychotic treatment responders and non-responders. However, the theragnostic potential of this biomarker to identi...

Sep 24, 2020

Abnormalities in the complement system have been described in patients with schizophrenia, with those individuals having greater frequency of complement component 4A (C4A) alleles and higher C4A trans...

Sep 24, 2020

It has been proposed that different stages of bipolar disorder may be underpinned by distinct neurobiological substrates. However, structural neuroimaging studies in early stages of the illness are li...

Sep 24, 2020

Clinical research has consistently established mental health conditions (MHCs) as frequent comorbidities of epilepsy. However, the extent of economic burden of comorbid MHC in patients with focal seiz...

Sep 24, 2020

The relationship between cognitive function and relapse of affective episodes in bipolar disorder (BD) is rarely studied. The aim of this prospective, longitudinal, case-control study was to assess th...

Sep 24, 2020

Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are highly prevalent and debilitating disorders. The high overlap on the symptomatic and neurobiological level led to ongoing deb...