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Psychiatry General

Efficacy of transcutaneous electrical acupoint stimulation for patients with first-episode schizophrenia: An 8-week, preliminary, randomized controlled trial.

May 29, 2023

Combination therapy with antipsychotics has been investigated for treating schizophrenia, and has shown clear advantages among non-invasive therapies. Transcutaneous electrical acupoint stimulation (T...

Longer Hospitalizations, More Complications, and Greater Readmissions for Patients with Comorbid Psychiatric Disorders Undergoing Pulmonary Lobectomy.

May 29, 2023

To examine the impact of comorbid psychiatric disorders on postoperative outcomes in pulmonary lobectomy patients.A retrospective analysis of the Healthcare Cost and Utilization Project Nationwide Rea...

The efficacy and safety of lurasidone in bipolar I depression with and without rapid cycling: A pooled post-hoc analysis of two randomized, placebo-controlled trials.

May 29, 2023

The efficacy and safety of lurasidone monotherapy in patients with bipolar I depression with or without rapid cycling has not been previously investigated.We performed subgroup analysis (rapid cycling...

A multicenter, double-blind, placebo-controlled, randomized, Phase 1b crossover trial comparing two doses of ulotaront with placebo in the treatment of narcolepsy-cataplexy.

May 22, 2023

Ulotaront (SEP-363856) is a novel agonist at trace amine-associated receptor 1 and serotonin 5-HT receptors in clinical development for the treatment of schizophrenia. Previous studies demonstrated ul...

Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model.

May 22, 2023

Narcolepsy type 1 (NT1) is a neurological disorder caused by disruption of hypocretin (HCRT; or orexin) neurotransmission leading to fragmented sleep/wake states, excessive daytime sleepiness (EDS), a...

Relation between white matter integrity, perfusion, and processing speed in early-stage schizophrenia.

May 22, 2023

Cerebral blood flow (CBF) plays a critical role in the maintenance of neuronal integrity, and CBF alterations have been linked to deleterious white matter changes. Several studies report CBF and white...

A clinical risk prediction tool for identifying the risk of violent offending in severe mental illness: A retrospective case-control study.

May 22, 2023

Individuals with severe mental illness are at a higher risk of violence than the general population. However, there is a lack of available and simple tools to screen for the risk of violent offending ...

Promoting research engagement among women with addiction: Impact of recovery peer support in a pilot randomized mixed-methods study.

May 22, 2023

The impact of involving peers on research engagement is largely unknown. The purpose of this pilot study, a part of a larger research, was to evaluate the impact of recovery peer involvement as a stud...

Dapagliflozin inhibits the activity of lateral habenula to alleviate diabetes mellitus-induced depressive-like behavior.

May 22, 2023

The prevalence of depression in diabetes mellitus (DM) patients is very high, and it severely impacts the prognosis and quality of life of these patients. Sodium-glucose co-transporter 2 (SGLT2) inhib...

Factors associated with objective and subjective cognitive impairment in Chinese patients with acute major depressive disorder.

May 22, 2023

Patients diagnosed withmajor depressive disorder (MDD) usually experience impaired cognitive functioning, which might negatively impact their clinical and functional outcomes. This study aimed to inve...

The role of NMDA receptors in bipolar disorder: A systematic review.

May 22, 2023

Glutamatergic transmission and N-methyl-D-aspartate receptors (NMDARs) have been implicated in the pathophysiology schizophrenic spectrum and major depressive disorders. Less is known about the role o...

The Chronic Pharmacological Antagonism of the CB Receptor is not Involved in the Behavioral Effects of Antidepressants Administered in Mice Submitted to Chronic Unpredictable Stress.

May 22, 2023

Several pieces of evidence suggest that the monoaminergic theory of depression cannot fully explain all behavioral and neuroplastic changes observed after antidepressant chronic treatment. Other molec...

Long-lasting restoration of memory function and hippocampal synaptic plasticity by focused ultrasound in Alzheimer's disease.

May 22, 2023

Focused ultrasound (FUS) is a medical technology that non-invasively stimulates the brain and has been applied in thermal ablation, blood-brain barrier (BBB) opening, and neuromodulation. In recent ye...

Airborne pollen grain detection from partially labelled data utilising semi-supervised learning.

May 22, 2023

Airborne pollen monitoring has been conducted for more than a century now, as knowledge of the quantity and periodicity of airborne pollen has diverse use cases, like reconstructing historic climates ...

Occurrence of Depression and Anxiety Resulting From Long-Term Exposure to Multiple Ambient Air Pollutants

May 16, 2023

The following is a summary of "Long-term Exposure to Multiple Ambient Air Pollutants and Incident Depression and Anxiety," published in the February 2023 issue of Psychiatry by Yang et al. For ...

Brain Binding of Serotonin 4 Receptor in MDD and Its Association with Memory Impairment

May 15, 2023

The following is a summary of "Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction," published in the February 2023 issue of Psychiatry by Köhler-F...

Neuroendocrine response to a psychosocial stress test is not related to schizotypy but cortisol elevation predicts inflexibility of semantic memory retrieval.

May 15, 2023

An altered stress response can contribute to the transition from preclinical psychotic symptoms to the clinical manifestation of schizophrenia and other psychotic disorders. The present study was aime...

The Association between Peripheral Inflammation, Brain Glutamate and Antipsychotic Response in Schizophrenia: data from the STRATA collaboration.

May 15, 2023

Glutamate and increased inflammation have been separately implicated in the pathophysiology of schizophrenia and the extent of clinical response to antipsychotic treatment. Despite the mechanistic lin...

Rhynchophylline inhibits methamphetamine dependence via modulating the miR-181a-5p/GABRA1 axis.

May 15, 2023

Uncaria rhynchophylla (Miq.) Miq. ex Havil. is a plant species that is routinely devoted in traditional Chinese medicine to treat central nervous system disorders. Rhynchophylline (Rhy), a predominant...

Effects of the DICE Method to Improve Timely Recognition and Treatment of Neuropsychiatric Symptoms in Early Alzheimer's Disease at the Memory Clinic: The BEAT-IT Study.

May 15, 2023

Neuropsychiatric symptoms (NPS) are highly prevalent in Alzheimer's disease (AD) and are associated with negative outcomes. However, NPS are currently underrecognized at the memory clinic and non-phar...

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