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Psychiatry General

Severe drug-induced liver injury in patients under treatment with antipsychotic drugs: data from the AMSP study.

Sep 10, 2020

Drug-induced liver injury has been associated with various antipsychotic drugs. Comparative studies between individual antipsychotic drugs are largely not available. Antipsychotic drug utilization da...

Manic-like presentation with an organic aetiology.

Sep 10, 2020

A 57-year-old man with chronic obstructive pulmonary disease (COPD), obstructive sleep apnoea (OSA) and no prior psychiatric history presented repeatedly over 6 months with mental and behavioural chan...

The mental health impact of the covid-19 pandemic on healthcare workers, and interventions to help them: A rapid systematic review.

Sep 10, 2020

The covid-19 pandemic has heavily burdened healthcare systems throughout the world. We performed a rapid systematic review to identify, assess and summarize research on the mental health impact of the...

Impact of clear aligner therapy on tooth pain and masticatory muscle soreness.

Sep 10, 2020

Clinical findings suggest that orthodontic treatment with clear aligners (clear aligner therapy/CAT ) may cause masticatory muscle soreness in some patients.This multi-site prospective study investiga...

Manganese-enhanced MRI Reveals Changes Within Brain Anxiety and Aversion Circuitry in Rats with Chronic Neuropathic Pain- and Anxiety-like Behaviors.

Sep 10, 2020

Chronic pain often predicts the onset of psychological distress. Symptoms including anxiety and depression after pain chronification reportedly are caused by brain remodeling/recruitment of the limbic...

Disentangling time series between brain tissues improves fMRI data quality using a time-dependent deep neural network: DeNN: Artificial intelligence for fMRI denoising.

Sep 10, 2020

Functional MRI (fMRI) is a prominent imaging technique to probe brain function, however, a substantial proportion of noise from multiple sources influences the reliability and reproducibility of fMRI ...

Ligand-based pharmacophore modelling and virtual screening for the identification of amyloid-beta diagnostic molecules.

Sep 10, 2020

Currently, only three molecules, flutemetamol, florbetaben and florbetapir, have been approved for clinical use towards the definitive diagnosis of Alzheimer's disease (AD). Despite the clinically app...

Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau.

Sep 10, 2020

The repeated failures of amyloid-targeting therapies have challenged our narrow understanding of Alzheimer's disease (AD) pathogenesis and inspired wide-ranging investigations into the underlying mech...

Nudge interventions to reduce fish sauce consumption in Thailand.

Sep 10, 2020

High sodium consumption is one of the four major risk factors contributing to non-communicable diseases around the world. Thailand has one of the highest rates of sodium consumption, with fish sauce b...

Analysis of Body Composition and Pain Intensity in Women with Chronic Pelvic Pain Secondary to Endometriosis.

Sep 10, 2020

 To determine the average body composition (percentage of body fat), the anthropometric markers, and the intensity of clinical pain in women with a clinical diagnosis of chronic pelvic pain (CPP) se...

Do Neonatal Infections Require a Positive Blood Culture?

Sep 10, 2020

Neonatal sepsis is a major cause of worldwide morbidity and mortality. Blood cultures are considered the gold standard for diagnosis, but results are often delayed for 24 to 48 hours, and sensitivit...

Impact of Preoperative Opioid Use on 2-Year Patient-Reported Outcomes in Knee Surgery Patients.

Sep 10, 2020

The objectives of this study are to assess perioperative opioid use in patients undergoing knee surgery and to examine the relationship between preoperative opioid use and 2-year postoperative patient...

Predictors of PROMIS Physical Function at 2 Years following Knee Surgery.

Sep 10, 2020

The purpose of this study was to evaluate Patient-Reported Outcomes Measurement Information System physical function (PROMIS PF) 2 years following knee surgery, and identify preoperative factors assoc...

Absence of Iodinated Contrast Hypersensitivity and Characterization of Gadolinium Utilization in an Interventional Pain Population.

Sep 10, 2020

Iodinated contrast media (ICM) allergy labels pose a unique clinical problem for the interventional pain physician due to the drawbacks of gadolinium for enhancement during pain procedure, as well as ...

Insomnia Interventions in the Workplace: A Systematic Review and Meta-Analysis.

Sep 07, 2020

The aim of this systematic review and meta-analysis was to identify and evaluate the impact of interventions to improve or reduce insomnia in the workforce through randomized clinical trials. Followin...

New pharmacologic agents for insomnia and hypersomnia.

Sep 07, 2020

Insomnia and hypersomnia are conditions with multifactorial causes that can be difficult to treat. There have been recent developments and changes in the treatment of both conditions, including the ad...

The history of multiple adverse childhood experiences in patients with schizophrenia is associated with more severe symptomatology and suicidal behavior with gender-specific characteristics.

Sep 07, 2020

The current study aims to compare the prevalence of adverse childhood experiences (ACEs) between patients with schizophrenia and non-psychiatric control group, and to analyze the association of having...

Associations between hypomania proneness and attentional bias to happy, but not angry or fearful, faces in emerging adults.

Sep 07, 2020

Mania, the core feature of bipolar disorder, is associated with heightened and positive emotion responding. Yet, little is known about the underlying cognitive processes that may contribute to heighte...

Cannabinoid-Induced Psychosis: A Cross-Sectional Gender Study.

Sep 07, 2020

Gender is a crucial factor in the development of mental illnesses, with an essential influence on clinical characteristics and not only on the prevalence of each disorder. Gender differences in cannab...

Involvement of noradrenergic and serotonergic systems in risk-based decisions between options of equivalent expected value in rats.

Sep 07, 2020

Risk perception is an important factor that may mediate risk-based decision-making processes regulated by noradrenergic (NA) and serotonergic (5-HT) systems. Most risk-based decision-making models inv...

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