Sep 07, 2020

The opioid epidemic continues to cause significant morbidity and mortality. Although there are effective medications for opioid use disorder (OUD), a minority of patients receive these treatments. OUD...

Sep 07, 2020

Pregnant women are increasingly being prescribed and abusing opioid drugs. As the primary communication organ between mother and conceptus, the placenta may be vulnerable to opioid effects but also ho...

Sep 07, 2020

Non-pharmacological interventions such as physiotherapy are recognized as important elements in the overall clinical management of motor impairments in PD, but evidence of physiotherapy in advanced di...

Sep 07, 2020

Neuroinflammation is believed to play a primary role in the pathogenesis of most neurodegenerative diseases including Alzheimer's disease, Parkinson's and schizophrenia. Currently, suitable in vitro n...

Sep 07, 2020

Tau hyperphosphorylation is involved in the progression of Alzheimer's disease (AD). In this study, we aimed to evaluate the role of linc00507 in modulating Tau phosphorylation in AD animal and Aβ42-...

Sep 07, 2020

Inactive aldehyde dehydrogenase-2 (ALDH2) is a well-known deterrent to the development of alcohol use disorder (AUD), however, some individuals with inactive ALDH2 do go on to develop AUD. These alcoh...

Sep 07, 2020

Antipsychotic effects of immunomodulating drugs have been suggested; however, a thorough, comprehensive meta-analysis on the effect and safety of anti-inflammatory add-on treatment on psychotic disord...

Sep 07, 2020

Restless sleep disorder (RSD) is a newly recognized condition characterized by motor movements involving large muscle groups with frequent repositioning or bed sheets disruption. We analyzed cyclic al...

Sep 07, 2020

The clinical features and course of bipolar disorder differ between women and men; however, studies are limited in Indian population. The objective of this study was to identify gender differences in ...

Sep 07, 2020

Alterations in thyroid hormone levels may affect brain and mental disorders. Conversely, schizophrenia and its antipsychotic treatments can affect thyroid hormone levels. However, data on thyroid hor...

Sep 04, 2020

Opioid substitution therapy includes supplying illicit drug users with replacement drugs like methadone and buprenorphine. The objective of this study is to compare the risk of all-cause and overdose ...

Sep 04, 2020

Alcohol consumption across the world is on the rise. While excessive alcohol consumption is associated with cognitive decline and other health outcomes, the effects of moderate alcohol consumption are...

Sep 04, 2020

Serum uric acid (SUA) levels indicate the amount of uric acid present in the blood. Higher SUA levels have been associated with an increased risk of hyperuricemia and kidney stones, but the overall he...

Sep 04, 2020

Benzodiazepines are a class of psychoactive drugs used in the treatment of insomnia, panic disorders, anxiety, and other mental health disorders. Common side effects of benzodiazepines, like drowsines...

Sep 03, 2020

Due to the serious situation of the novel coronavirus disease 2019 (COVID-19) worldwide, many countries have implemented policies to minimize the spread of COVID-19 infection. However, some of these p...

Sep 03, 2020

Brain-derived neurotrophic factor (BDNF) is associated with depression, pain, or sleep disorders, factors that are thought to be involved in the pathogenesis and clinical course of Crohn's disease (CD...

Sep 03, 2020

Psychiatry is nearly entirely reliant on patient self-reporting, and there are few objective and reliable tests or sources of collateral information available to help diagnostic and assessment procedu...

Sep 03, 2020

The diagnostic criteria for schizophrenia comprise a diverse range of heterogeneous symptoms. As a result, individuals each present a distinct set of symptoms despite having the same overall diagnosis...

Sep 03, 2020

Despite the importance of emotional intelligence, its biological mechanism is still not well understood. For this reason, we have developed a rodent detour task which requires an animal to reach a hig...

Sep 03, 2020

Ketamine demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive effect in TRD is unclear. We aim to (1) characterize baseli...