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Psychiatry General

Brain-derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti-TNF-α treatment-A pilot study.

Sep 03, 2020

Brain-derived neurotrophic factor (BDNF) is associated with depression, pain, or sleep disorders, factors that are thought to be involved in the pathogenesis and clinical course of Crohn's disease (CD...

Utilizing Machine Learning on Internet Search Activity to Support the Diagnostic Process and Relapse Detection in Young Individuals With Early Psychosis: Feasibility Study.

Sep 03, 2020

Psychiatry is nearly entirely reliant on patient self-reporting, and there are few objective and reliable tests or sources of collateral information available to help diagnostic and assessment procedu...

Multi-dimensional predictions of psychotic symptoms via machine learning.

Sep 03, 2020

The diagnostic criteria for schizophrenia comprise a diverse range of heterogeneous symptoms. As a result, individuals each present a distinct set of symptoms despite having the same overall diagnosis...

Assessment of Problem-Solving Skills and Inhibitory Control in Mice Using Water Escape Detour Test.

Sep 03, 2020

Despite the importance of emotional intelligence, its biological mechanism is still not well understood. For this reason, we have developed a rodent detour task which requires an animal to reach a hig...

Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression.

Sep 03, 2020

Ketamine demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive effect in TRD is unclear. We aim to (1) characterize baseli...

[Workplace and Work-Related Return to Work Interventions for Employees with Common Mental Disorders: Between Health-Promoting Organisational Development and Self-Management].

Sep 03, 2020

Work-related interventions and alliances between healthcare institutions and companies that aim to support employees with common mental disorders (CMD) returning to work are still quite rare in German...

Review of beneficial effects of resveratrol in neurodegenerative diseases such as Alzheimer's disease.

Sep 03, 2020

The prevalence of Alzheimer's Disease is rising, in part due to increase in the medium age of residents in developed countries. The aim of the study has been to determine whether resveratrol (RSV) can...

Intracranial vascular flow oscillations in Alzheimer's disease from 4D flow MRI.

Sep 03, 2020

Recent modeling and experimental evidence suggests clearance of soluble metabolites from the brain can be driven by low frequency flow oscillations (LFOs) through the intramural periarterial drainage ...

Longitudinal trajectories of mood symptoms and global functioning in youth at high risk for bipolar disorder.

Sep 03, 2020

Little is known about the longitudinal course of mood symptoms and functioning in youth who are at high risk for bipolar disorder (BD). Identifying distinct course trajectories and predictors of those...

Underlying domains of anxiety trait in a Costa Rican sample: preliminary results.

Sep 03, 2020

Imprecision of the psychiatric phenotype might partially explain the failure of genetic research to identify genes that contribute to susceptibility of anxiety disorders. Previous research concluded t...

Association of pro-inflammatory cytokines with clinical features in euthymic patients with Bipolar-I-Disorder.

Sep 03, 2020

A chronic low-grade inflammatory state appears to be a relevant mechanism in the pathophysiology of bipolar disorder. Pro-inflammatory cytokines may influence disease course and individual symptomatol...

Mental disorders and subsequent suicide events in a representative community population.

Sep 03, 2020

This study examined the patterns of association between mental disorders and subsequent suicide in a community sample representative of the Canadian household population.This retrospective cohort stud...

Effect of adjunctive pimavanserin on suicidal ideation in patients with major depression: Analysis of the CLARITY study.

Sep 03, 2020

Up to 15% of patients with major depressive disorder (MDD) attempt suicide and up to 2% complete suicide. This was a post-hoc analysis aimed to evaluate the risk of suicide ideation and behavior assoc...

Prediction of clinical and biomarker conformed Alzheimer's disease and mild cognitive impairment from multi-feature brain structural MRI using age-correction from a large independent lifespan sample.

Sep 03, 2020

Structural neuroimaging has been applied to the identification of individuals with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, these methods are greatly impacted by age limi...

Thienorphine induces antinociception without dependence through activation of κ- and δ-, and partial activation of μ- opioid receptor.

Sep 03, 2020

Thienorphine hydrochloride is a new anti-relapse drug for opioid abusers that is currently in phase II clinical trial. In the present study, the antinociception, dependence, and signal transduction in...

Review of addiction risk potential associated with adolescent opioid use.

Sep 03, 2020

Adolescence is a critical period of development with robust behavioral, morphological, hormonal, and neurochemical changes including changes in brain regions implicated in the reinforcing effects of d...

Postoperative Opioid Utilization Associated with Revision Risk Following Primary Shoulder Arthroplasty.

Sep 03, 2020

With a substantial increase in utilization of primary shoulder arthroplasty, it is important to understand risk factors that may signal early failure and need for revision. Recent studies have reporte...

Genomic signatures of honey bee association in an acetic acid symbiont.

Sep 03, 2020

Recent declines in the health of the honey bee have startled researchers and lay people alike as honey bees are agriculture's most important pollinator. Honey bees are important pollinators of many ma...

An intracochlear DP-gram: Proof of principle in noise-damaged rabbits.

Sep 03, 2020

Distortion-product otoacoustic emissions (DPOAEs) can be used to assess cochlear damage and are often evaluated by generating a DP-gram in which 2f-f DPOAE levels are plotted as a function of the high...

Functional and radiological outcome of anterior retroperitoneal versus posterior transforaminal interbody fusion in the management of single-level lumbar degenerative disease.

Sep 03, 2020

In this study the authors compared the anterior lumbar interbody fusion (ALIF) and posterior transforaminal lumbar interbody fusion (TLIF) techniques in a homogeneous group of patients affected by sin...

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