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Psychiatry General

Characteristics of Neuropsychiatric Mobile Health Trials: Cross-Sectional Analysis of Studies Registered on ClinicalTrials.gov.

Aug 06, 2020

The development of mobile health (mHealth) technologies is progressing at a faster pace than that of the science to evaluate their validity and efficacy. Under the International Committee of Journal M...

The prevalence of psychiatric symptoms before the diagnosis of Parkinson's disease in a nationwide cohort: A comparison to patients with cerebral infarction.

Aug 06, 2020

Psychiatric symptoms (PS) can be non-motor features in Parkinson's disease (PD) which are common even in the prodromal, untreated phase of the disease. Some PS, especially depression and anxiety recen...

Sex differences in the effects of a combined behavioral and pharmacological treatment strategy for cocaine relapse prevention in an animal model of cue exposure therapy.

Aug 06, 2020

Brief interventions of environmental enrichment (EE) or the glycine transporter-1 inhibitor Org24598 administered with cocaine-cue extinction training were shown previously to inhibit reacquisition of...

The magnitude and heterogeneity of antidepressant response in depression: A meta-analysis of over 45,000 patients.

Aug 06, 2020

To determine the relative variability and magnitude of symptomatic improvement in antidepressant-treated individuals compared to placebo-treated individuals, and to investigate moderating factors.Mult...

Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress.

Aug 06, 2020

The association between distress caused by tinnitus and psychological factors such as depression and anxiety has been examined and reported. However, prognostic factors remain poorly understood becaus...

Catatonia in elderly psychiatric inpatients is not always associated with intense anxiety: factor analysis and correlation with psychopathology.

Aug 06, 2020

Catatonic stupor has been linked to extreme fear. Whether the underlying phenomenology of every catatonic dimension is intense anxiety or fear remains unknown.106 patients aged ≥64 years were asse...

Correlates of dual-task performance in people with multiple sclerosis: A systematic review.

Aug 06, 2020

Gait, balance, and cognitive disorders are common in people with Multiple Sclerosis (MS). In addition, people with MS have impaired ability to concurrently perform gait/balance and cognitive tasks due...

The concept and management of acute episodes of treatment-resistant bipolar disorder: a systematic review and exploratory meta-analysis of randomized controlled trials.

Aug 06, 2020

The definitions of treatment-resistant bipolar disorder (TRBD) have varied across studies. Additionally, its management is clinically challenging. An updated synthesis and appraisal of the available e...

Effects of N -(4-hydroxybenzyl) adenine riboside in stress-induced insomnia in rodents.

Aug 06, 2020

Adenosine exhibits a somnogenic effect; however, there is no adenosinergic hypnotic because of cardiovascular effects. This study investigated whether N6-(4-hydroxybenzyl) adenine riboside (T1-11), ex...

Serum Activity Against G Protein-Coupled Receptors and Severity of Orthostatic Symptoms in Postural Orthostatic Tachycardia Syndrome.

Aug 06, 2020

Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and orthostatic intolerance. Previous data indicate autoimmune involvement. We...

Novel hybrid compounds, opioid agonist+melanocortin 4 receptor antagonist, as efficient analgesics in mouse neuropathic pain model.

Aug 06, 2020

When the nerve tissue is injured, endogenous agonist of melanocortin type 4 (MC4) receptor, α-MSH, exerts tonic pronociceptive action in the central nervous system, contributing to sustaining the neu...

Benzimidazole based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T.

Aug 06, 2020

Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To detect amyloid fibrils, fluorophores with...

Where and how alpha-synuclein pathology spreads in Parkinson's disease.

Aug 06, 2020

In Parkinson's disease (PD), neuronal alpha-synuclein aggregates are distributed throughout the nervous system, including the brain, spinal cord, sympathetic ganglia, submandibular gland, enteric nerv...

Structure of intact chitinase with hevein domain from the plant Simarouba glauca, known for its traditional anti-inflammatory efficacy.

Aug 06, 2020

Chitinase from the leaves of Simarouba glauca, a plant used in traditional anti-inflammatory therapy is purified and characterized. Peptide mass finger print analysis revealed the protein as an endo-c...

I Will Be at Your (Bed)Side - The Role of Bedside Echocardiography for Non-Cardiologists.

Aug 06, 2020

As the availability of portable echocardiographic equipment is becoming more and more widespread, physicians can add a powerful tool to their bedside examination skills, thus helping them to more effe...

Magnetic nanoemulsions as candidates for alzheimer's disease dual imaging theranostics.

Aug 06, 2020

Alzheimer's disease (AD) is the most prevalent cause of dementia linked to the accumulation of amyloid-beta (Aβ) plaques-fibrils that impair cognitive functions. Magnetic nanoparticles (MNPs) are eme...

First-line gemcitabine plus nab-paclitaxel for elderly patients with metastatic pancreatic cancer: Crossing the frontier of age?

Aug 06, 2020

Gemcitabine plus nab-paclitaxel (Gem-Nab) represents a standard first-line treatment for metastatic pancreatic cancer (mPC), but few data are available for elderly patients. We aimed to add evidence a...

Enhanced Recovery After Surgical Correction of Adolescent Idiopathic Scoliosis.

Aug 06, 2020

Few publications in the literature examine enhanced recovery after scoliosis surgery (ERAS) in children, despite significant scientific interest in adults. The objective of the current study was to de...

Association of thyroid peroxidase antibodies with anti-neuronal surface antibodies in health, depression and schizophrenia- complementary linkage with somatic symptoms of major depression.

Aug 06, 2020

Hashimoto's thyroiditis has been associated with major depression (MD) and schizophrenia (Sz) in epidemiological studies. However, diagnostically relevant antibodies (Abs) against thyroid peroxidase (...

The COVID-19 pandemic and patients with endometriosis: A survey-based study conducted in Turkey.

Aug 06, 2020

To apply rapid online surveying to determine the knowledge and perceptions of the COVID-19 pandemic on patients with endometriosis in Turkey.An online survey was conducted by the Turkish Endometriosis...

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