Apr 28, 2020

Several lines of evidence from neuropathological studies, human genetics, in vitro aggregation studies and cellular and animal models support the hypothesis that aSyn plays a central role in the forma...

Apr 28, 2020

Stigma is a known correlate of well-being for many neurological conditions. Perceived control is also an important variable in models of adaptation to living with a health condition. The purpose of th...

Apr 28, 2020

Previous reports proposed prelemniscal radiations (Raprl) as a target to treat motor symptoms of Parkinson's disease, and this was found particularly effective to control rest and postural tremor. How...

Apr 28, 2020

According to Nemeth et al. (2011), pediatric mania is difficult to distinguish from childhood hyperactivity. Both share 3 common symptoms: distractibility, motoric hyperactivity, and talkativeness (Bi...

Apr 28, 2020

Patients with bipolar disorder experience a wide range of depressive and manic symptoms. Only 2 drugs are FDA-approved to treat episodes of both mania and depression in patients with bipolar disorder,...

Apr 28, 2020

Delirious mania is a life-threatening condition, presenting with symptoms of acute delirium and psychotic mania as a complication of medical or psychiatric condition. It is not recognized as a diagnos...

Apr 28, 2020

Long-term maintenance treatment is essential in management of bipolar I disorder (BP-I) to achieve mood stability, prevent recurrence of mood episodes and improve functioning. Aripiprazole once-monthl...

Apr 28, 2020

It is being increasingly recognized that human mucosal surfaces are not sterile but are colonized with microorganisms collectively known as the microbiome. The microbiome can alter brain functioning i...

Apr 28, 2020

To date, to our knowledge there are no studies regarding attitudes and experiences of outpatient medical personnel during a pandemic. This study's aim was to evaluate the impact of the COVID-19 pandem...

Apr 28, 2020

Lithium is the gold standard in treating bipolar affective disorders. As patients become increasingly older, drug-drug interactions leading to decreased excretion of lithium represent a key issue in l...

Apr 28, 2020

Phenibut is a nootropic drug that exerts anxiolytic and antinociceptive effects by acting on the GABA receptor and the α-δ subunit of voltage-dependent calcium channels. An increased number of repor...

Apr 28, 2020

The FiCTION trial compared co-primary outcomes (dental pain and/or infection) and secondary outcomes (child oral health-related quality of life [COHRQOL], child dental anxiety, cost-effectiveness, car...

Apr 28, 2020

Microbial association networks are frequently used for understanding and comparing community dynamics from microbiome datasets. Inferring microbial correlations for such networks and obtaining meaning...

Apr 28, 2020

The SBML standard is used in a number of online repositories for storing systems biology models, yet there is currently no Web-capable JavaScript library that can read and write the SBML format. This ...

Apr 28, 2020

Effects of drug treatment of clinical Alzheimer-type dementia (CATD) are uncertain.To summarize evidence on the effects of prescription drugs and supplements for CATD treatment.Electronic bibliographi...

Apr 28, 2020

Biomarker accuracy for Alzheimer disease (AD) is uncertain.To summarize evidence on biomarker accuracy for classifying AD in older adults with dementia.Electronic bibliographic databases (searched fro...

Apr 28, 2020

Receptor-operated activation of TRPC4 cation channels requires G proteins and phospholipase-Cδ1 (PLCδ1) activation by intracellular Ca Concurrent stimulation of G pathway accelerates G activation of...

Apr 28, 2020

Background and aims Patients usually receive a prescription for morphine or another opioid at discharge after surgery. Several studies have shown that many patients do not step down but develop persis...

Apr 28, 2020

Background and aims There is very little published evaluation of the treatment of military veterans with chronic pain, with or without post-traumatic stress disorder. Few clinical services offer integ...

Apr 28, 2020

To address the opioid crisis, much work has focused on minimizing opioid supply to surgical patients upon hospital discharge. Research is limited regarding handover to primary care providers. The aim ...