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Psychiatry General

Accuracy of Biomarker Testing for Neuropathologically Defined Alzheimer Disease in Older Adults With Dementia: A Systematic Review.

Apr 28, 2020

Biomarker accuracy for Alzheimer disease (AD) is uncertain.To summarize evidence on biomarker accuracy for classifying AD in older adults with dementia.Electronic bibliographic databases (searched fro...

Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca dependent manner.

Apr 28, 2020

Receptor-operated activation of TRPC4 cation channels requires G proteins and phospholipase-Cδ1 (PLCδ1) activation by intracellular Ca Concurrent stimulation of G pathway accelerates G activation of...

Opioid tapering after surgery: a qualitative study of patients' experiences.

Apr 28, 2020

Background and aims Patients usually receive a prescription for morphine or another opioid at discharge after surgery. Several studies have shown that many patients do not step down but develop persis...

Military veterans with and without post-traumatic stress disorder: results from a chronic pain management programme.

Apr 28, 2020

Background and aims There is very little published evaluation of the treatment of military veterans with chronic pain, with or without post-traumatic stress disorder. Few clinical services offer integ...

Evaluation of communication to general practitioners when opioid-naïve post-surgical patients are discharged from hospital on opioids.

Apr 28, 2020

To address the opioid crisis, much work has focused on minimizing opioid supply to surgical patients upon hospital discharge. Research is limited regarding handover to primary care providers. The aim ...

Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway.

Apr 28, 2020

Hypoxia induces reversible κ-opioid receptor (KOR) internalization similar to the internalization that is induced by KOR agonists. In the current study, we demonstrate that this KOR internalization i...

Maternal spontaneous abortion and the risk of attention-deficit/hyperactivity disorder in offspring: a population-based cohort study.

Apr 28, 2020

Is a maternal history of spontaneous abortion (SA) associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring?Our results suggest an association between maternal...

[Mental Distress and Resilience in Severe Somatic Diseases: An Analysis of Dyadic Relations].

Apr 28, 2020

In this article, we present 3 studies examining patients with current or previous severe physical illness and their partners with respect to dyadic concordance, gender and role differences in mental d...

Suicidal ideation and suicide attempts: associations with sleep duration, insomnia, and inflammation.

Apr 24, 2020

Sleep disturbance has been consistently identified as an independent contributor to suicide risk. Inflammation has emerged as a potential mechanism linked to both sleep disturbance and suicide risk. T...

Sleep disturbance mediates the link between childhood trauma and clinical outcome in severe mental disorders.

Apr 24, 2020

The experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the re...

Autism Spectrum Disorder and Narcolepsy: A Possible Connection That Deserves to Be Investigated.

Apr 24, 2020

Narcolepsy in childhood-adolescence is characterized by a high occurrence of psychiatric comorbidities. The most frequent psychiatric disorders reported in these patients are attention deficit/hyperac...

The epidemiology of regular opioid use and its association with mortality: Prospective cohort study of 466 486 UK biobank participants.

Apr 24, 2020

Opioids have, at most, small benefits for non-cancer pain in the medium and long-term but there is good evidence that they cause harm. The current study describes the characteristics and clinical stat...

Cognitive functioning, sleep quality, and work performance in non-clinical burnout: The role of working memory.

Apr 24, 2020

We investigated the relationship between cognitive functioning, work performance, and sleep in non-clinical burnout. In a working population, an online survey was conducted with additional online neur...

Predictors of criminal offending in a clinical sample of patients diagnosed with schizophrenia: A 6-year follow-up study.

Apr 24, 2020

Criminal behavior in schizophrenia has been associated with a number of risk factors including symptoms of schizophrenia, co-occurring personality disorders (PDs), substance abuse, intellectual and co...

Using Complexity Assessment to Inform the Development and Deployment of a Digital Dashboard for Schizophrenia Care: Case Study.

Apr 24, 2020

Health care is becoming more complex. For an increasing number of individuals, interacting with health care means addressing more than just one illness or disorder, engaging in more than one treatment...

The role of pituitary adenylyl cyclase-activating polypeptide in the motivational effects of addictive drugs.

Apr 24, 2020

Pituitary adenylyl cyclase activating polypeptide (PACAP) was originally isolated from the hypothalamus and found to stimulate adenylyl cyclase in the pituitary. Later studies showed that this peptide...

The Effect of Auditory Verbal Hallucinations on the Relationship between Spontaneous Brain Activity and intraventricular Brain Temperature in Patients with Drug-Naïve Schizophrenia.

Apr 24, 2020

Our recent study reported that adolescent-onset schizophrenia showed an uncoupling between intraventricular brain temperature (iBT) and local spontaneous brain activity (SBA). While auditory verbal ha...

Prevalence and predictors of hazardous alcohol use among tuberculosis patients: the need for a policy on joint tuberculosis-alcohol collaborative activities in India.

Apr 24, 2020

Collaborative activities to address tobacco addiction among tuberculosis (TB) patients are in place in India. The research was carried out to estimate the prevalence and to determine the predictors of...

Approach bias for erotic stimuli among heterosexual female college students who use pornography.

Apr 24, 2020

Repeated engagement in addictive behaviors may lead to relatively automatic action tendencies whereby individuals approach rather than avoid addictive stimuli. This study assessed whether an approach ...

First radiolabeling of a ganglioside with a positron emitting radionuclide - in vivo PET demonstrates low exposure of radiofluorinated GM1 in non-human primate brain.

Apr 24, 2020

Gangliosides are biologically important glycolipids widely distributed in vertebrate cells. An important member of the ganglioside family is the monosialylganglioside GM1, which has been suggested as ...

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