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Psychiatry General

Ferrous sulfate-directed dual-cross-linked hyaluronic acid hydrogels with long-term delivery of donepezil.

Apr 12, 2020

Ferrous sulfate (FeSO)-directed dual-cross-linked hydrogels were designed for application in single-syringe injections. The use of FeSO, rather than other iron salts, can modulate the gelation time an...

A comparison of resting state EEG and structural MRI for classifying Alzheimer's disease and mild cognitive impairment.

Apr 12, 2020

Alzheimer's disease (AD) is the leading cause of dementia, accounting for 70% of cases worldwide. By 2050, dementia prevalence will have tripled, with most new cases occurring in low- and middle-incom...

Volunteering, polygenic risk for Alzheimer's disease, and cognitive functioning among older adults.

Apr 12, 2020

In the context of the public health burden posed by increases in Alzheimer's Disease (AD) prevalence around the globe and the related research efforts to identify modifiable risk factors for the disea...

Large-scale network dysfunction in the acute state compared to the remitted state of bipolar disorder: A meta-analysis of resting-state functional connectivity.

Apr 12, 2020

Bipolar disorder (BD) is a mental disorder characterized by mood fluctuations between an acute episodic state of either mania or depression and a clinically remitted state. Dysfunction of large-scale ...

Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings.

Apr 12, 2020

Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania or between depression and mixed states, often associated with functional i...

Contributing Factors to Heterogeneity in the Timing of the Onset of Nonfatal Suicidal Behavior: Results From a Nationally Representative Study.

Apr 12, 2020

It remains unclear whether specific clinical factors contribute to heterogeneity in the timing of the onset of nonfatal suicidal behavior. This knowledge could have important implications for suicide ...

Clinical response and metabolic effects of lithium in 323 mood disorder patients.

Apr 12, 2020

Lithium is the mainstay for the maintenance treatment of mood disorders (MD), but its efficacy needs to be weighed against its side effects profile. Here, we assessed retrospectively the clinical resp...

Aristotle on manic-depressive illness and greatness.

Apr 12, 2020

To reanalyze Aristotle's classic lecture, "On melancholy," with current clinical interpretations METHOD: The full lecture is described and interpreted in a new translation.Aristotle's lecture has been...

Exposure to low doses of inorganic arsenic induces transgenerational changes on behavioral and epigenetic markers in zebrafish (Danio rerio).

Apr 12, 2020

The ability of environmental pollutants to alter the epigenome with resultant development of behavioral alterations has received more attention in recent years. These alterations can be transmitted an...

The error-related negativity (ERN) moderates the association between interpersonal stress and anxiety symptoms six months later.

Apr 12, 2020

Anxiety disorders are often preceded by interpersonal stress; however, most individuals who experience stress do not develop anxiety, making it difficult to predict who is most susceptible to stress. ...

Maternal Prenatal Mood, Pregnancy-Specific Worries, and Early Child Psychopathology: Findings From the DREAM BIG Consortium.

Apr 12, 2020

Few studies have attempted to identify how distinct dimensions of maternal prenatal affective symptoms relate to offspring psychopathology. We defined latent dimensions of women's prenatal affective s...

Ozone increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression: Role of stress hormones.

Apr 12, 2020

Air pollution is associated with adverse impacts on the brain, including cognitive decline and increased incidence of dementia, depression and anxiety; however, underlying mechanisms remain unclear. W...

Evaluation of women's worries in different strategies for the prevention of early onset group B streptococcal disease in neonates.

Apr 12, 2020

Early onset group B streptococcal (EOGBS) disease is an important cause of neonatal morbidity and mortality. EOGBS preventive strategies aim to reduce the risk of neonatal complications. Two new strat...

Multicolor 4D printing of shape-memory polymers for light-induced selective heating and remote actuation.

Apr 12, 2020

Four-dimensional (4D) printing can add active and responsive functions to three-dimensional (3D) printed objects in response to various external stimuli. Light, among others, has a unique advantage of...

The SLC6A3 gene polymorphism is related to the development of attentional functions but not to ADHD.

Apr 12, 2020

Neuropharmacological and human clinical studies have suggested that the brain dopaminergic system is substantively involved in normal and pathological phenotypes of attention. Dopamine transporter gen...

EARLY ONSET DEMYELINATING CHARCOT-MARIE-TOOTH DISEASE CAUSED BY A NOVEL IN-FRAME ISOLEUCINE DELETION IN PERIPHERAL MYELIN PROTEIN 2.

Apr 12, 2020

Peripheral Myelin Protein 2 (PMP2) is a small protein located on the cytoplasmic side of compact myelin, involved in the lipids transport and in the myelination process. In the last years few families...

Lymph node harvesting in gastric cancer: the crucial role of t stage.

Apr 12, 2020

Nodal status represents probably the most important determinant of gastric cancer prognosis. The purpose of the present study was to assess the impact of the primary tumor's T stage on lymph node harv...

Portable Nanopore Analytics: Are We There Yet?

Apr 12, 2020

Oxford Nanopore technologies (ONT) add miniaturization and real-time to high-throughput sequencing. All available software for ONT data analytics run on cloud/clusters or personal computers. Instead, ...

Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.

Apr 12, 2020

Neuropathic pain remains a significant unmet medical need. Several recommendations have recently been proposed concerning pharmacotherapy, neurostimulation techniques and interventional management, bu...

Prescription opioid overdose and adverse effect hospitalisations among injured workers in eight states (2010-2014).

Apr 12, 2020

High-risk opioid prescribing practices in workers' compensation (WC) settings are associated with excess opioid-related morbidity, longer work disability and higher costs. This study characterises the...

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