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Psychiatry General

Subjective and objective sleep differ in male and female collegiate athletes.

Mar 10, 2020

Despite the importance of sleep for athletic performance, there is a lack of normative sleep data and sex comparisons in collegiate athletes. The primary purpose of our study was to assess the prevale...

Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes - Possible Link.

Mar 10, 2020

There is increasing number of the patients worldwide with sleep disturbances and diabetes. Various sleep disorders, including long or short sleep duration and poor sleep quality of numerous causes, ma...

CSF levels of the endocannabinoid anandamide are reduced in patients with untreated narcolepsy type 1: a pilot study.

Mar 10, 2020

Background The endocannabinoid system (ECs) is involved in excitatory/inhibitory balance mechanisms within the CNS. Growing evidence shows that endocannabinois may influence both hypothalamic orexiner...

Association between 5-HT gene polymorphism rs140700 and primary insomnia in Chinese population.

Mar 10, 2020

Primary insomnia is a worldwide problem and it has a considerable negative impact on one's physical and mental health. Studies have shown that non-synonymous SNPs in 5-hydroxytryptamine(serotonin or 5...

A Case of Schizophrenia in a Young Male Adult with no History of Substance Abuse: Impact of Clinical Pharmacists' Interventions on Patient Outcome.

Mar 10, 2020

Schizophrenia is a chronic and severe mental disorder characterized by distortions in thinking, perception, emotions, language, sense of self, and behaviour. This report presents the role of clinical ...

Prevalence and associated factors of suicide among hospitalized schizophrenic patients.

Mar 10, 2020

Previous studies found several factors associated with suicide in schizophrenic patients, such as age, sex, education level, history of suicide attempts, psychotic symptoms, social factors, and substa...

Characterization of deficit schizophrenia and reliability of the bidimensional model of its negative symptomatology.

Mar 10, 2020

Cumulative evidence has demonstrated important differences between deficit (DS) and non-deficit (NDS) schizophrenia, suggesting that DS may be a separate disease. However, most data come from the sam...

Oral health treatment habits of people with schizophrenia in France: A retrospective cohort study.

Mar 10, 2020

To identify the differences between persons with schizophrenia (PWS) and general population in France in terms of oral health treatment (tooth scaling, dental treatment and tooth extraction) and the f...

Predicting Alcohol Dependence Treatment Outcomes: A Prospective Comparative Study of Clinical Psychologists vs 'Trained' Machine Learning Models.

Mar 10, 2020

Clinical staff are typically poor at predicting alcohol dependence treatment outcomes. Machine Learning (ML) offers the potential to model complex clinical data more effectively. This study tested the...

mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia.

Mar 10, 2020

Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However,...

[Autism, depression and risk of suicide].

Mar 10, 2020

Autism is a neurodevelopmental disorder characterized by a qualitative alteration in social interaction and communication, associated with restricted interests and stereotyped behaviors. People with a...

[From autism spectrum to autism constellation].

Mar 10, 2020

Research on autism and mental disorders has been unsuccessful over the past few decades, as can be inferred from the poor results related to advances in other diseases. It is concerning that, after mo...

TV 3326 for Alzheimer's dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer's-like neuropathology.

Mar 10, 2020

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders and a well-recognized cause of dementia with ageing. In this review, we have represented the ChE and MAO inhibitory po...

Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease.

Mar 10, 2020

As Parkinson's disease progresses, levodopa treatment loses efficacy, partly through the loss of the endogenous dopamine-synthesizing enzyme L-amino acid decarboxylase (AADC). In the phase I PD-1101 s...

Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer's Disease.

Mar 10, 2020

Overactivation of ryanodine receptors and the resulting impaired calcium homeostasis contribute to Alzheimer's disease-related pathophysiology. This study hypothesized that exposing neuronal progenito...

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies.

Mar 10, 2020

Human cell-based neural organoids are increasingly being used for investigations of neurotoxicity, and to study the pathophysiology of neurodegenerative diseases. Here, we present a fast and robust me...

A longitudinal study on α-synuclein in plasma neuronal exosomes as a biomarker for Parkinson's disease development and progression.

Mar 10, 2020

The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exo...

Antidepressant-Associated Mania in Bipolar Disorder: A Review and Meta-analysis of Potential Clinical and Genetic Risk Factors.

Mar 10, 2020

Antidepressants (ADs) play a valuable role in treating the depressive episodes of bipolar disorder. However, 14% of these individuals taking ADs experience AD-associated mania (AAM) within a few weeks...

Electroconvulsive therapy in a 91-year old Asian lady with late onset bipolar mania.

Mar 10, 2020

Electroconvulsive therapy (ECT) is safe and efficacious in the elderly population. However, clinicians are still weary to use it among the old-old population, citing safety concerns. Our case report h...

Examining the Neuropsychiatric Sequelae Postsurgical Resection of Adult Brain Tumors Through a Scoping Review.

Mar 10, 2020

Improving brain tumor survival rates have drawn increasing focus on neuropsychiatric and psychological outcomes.This review characterizes the literature on neuropsychiatric sequelae after neurosurgica...

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