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Psychiatry General

An fMRI Study of the Effects of Vibroacoustic Stimulation on Functional Connectivity in Patients with Insomnia.

Feb 25, 2020

It is well known that vibratory and auditory stimuli from vehicles such as cars and trains can help induce sleep. More recent literature suggests that specific types of vibratory and acoustic stimulat...

The effect of self-help cognitive behavioral therapy for insomnia on depressive symptoms: An updated meta-analysis of randomized controlled trials.

Feb 25, 2020

Sleep disturbances commonly occur in patients with depression. Insomnia is considered not only a symptom of but also a risk factor for depression. Psychological treatments for insomnia have been demon...

Depression and trait-anxiety mediate the influence of clinical pain on health-related quality of life in fibromyalgia.

Feb 25, 2020

Fibromyalgia syndrome (FMS) is a chronic pain condition associated with a substantial decrease in health-related quality of life (HRQoL). This study investigated the relationships of HRQoL with clinic...

Achieving complete mental health despite a history of generalized anxiety disorders: Findings from a large, nationally representative Canadian survey.

Feb 25, 2020

Ideally, the clinical goal for individuals with a history of anxiety disorder is not only to remit from the disorder, but also to reach optimal well-being. This broader concept of recovery aligns with...

Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls.

Feb 25, 2020

Apathy is a central predictor of a poor functional outcome in schizophrenia. Schizophrenia polygenic risk scores (PRS) are used to detect genetic associations to key clinical phenotypes in schizophren...

Similarities and Differences Across Bipolar Disorder Subtypes Among Adolescents.

Feb 25, 2020

To compare demographic, clinical, and familial characteristics across bipolar disorder (BD) subtypes in adolescents. A total of 168 participants, 13 to 19 years of age, with BD-I ( = 41), BD-II ...

Feasibility of remotely supervised transcranial direct current stimulation and cognitive remediation: A systematic review.

Feb 25, 2020

With technological advancements and an aging population, there is growing interest in delivering interventions at home. Transcranial Direct Current Stimulation (tDCS) and Cognitive Remediation (CR) as...

Quality of life and its association with psychiatric symptoms and socio-demographic characteristics among people with schizophrenia: A hospital-based cross-sectional study.

Feb 25, 2020

To identify sociodemographic and illness-related factors associated with quality of life among people with Schizophrenia.A hospital-based cross-sectional study design was employed among 351 people wit...

Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats.

Feb 25, 2020

The orbitofrontal cortex (OFC) plays a fundamental role in motivated behavior and decision-making. In humans, OFC structure and function is significantly disrupted in drug using and dependent individu...

Dissatisfaction of women with induction of labour according to parity: Results of a population-based cohort study.

Feb 25, 2020

To determine the factors associated with dissatisfaction in women whose labour was induced, according to parity.Prospective population-based cohort study.Seven French perinatal health networks includi...

History of suicidality and alcohol craving trajectories during inpatient treatment for alcohol use disorder.

Feb 25, 2020

Alcohol use is associated with an increased risk of completed suicide, but it is unclear whether past suicidality affects the course of alcohol use disorder (AUD). We examined whether a history of sui...

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin.

Feb 25, 2020

Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1)....

The power of the Functional Activities Questionnaire for screening dementia in rural-dwelling older adults at high-risk of cognitive impairment.

Feb 25, 2020

A simple approach to detecting dementia in its early stages may help improve patient care. We therefore aimed to assess the power of the Functional Activities Questionnaire (FAQ) for screening dementi...

Prepulse inhibition of the acoustic startle reflex and P50 gating in aging and Alzheimer's disease.

Feb 25, 2020

Inhibition plays a crucial role in many functional domains, such as cognition, emotion, and actions. Studies on cognitive aging demonstrate changes in inhibitory mechanisms are age- and pathology-rela...

Attenuated baroreflex in a Parkinson's disease animal model coincides with impaired activation of non-C1 neurons.

Feb 25, 2020

Orthostatic hypotension is one of the most common symptoms observed in Parkinson's disease (PD), a neurodegenerative disease caused by death of dopaminergic neurons in the substantia nigra pars compac...

Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease.

Feb 25, 2020

Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some tumor suppressors, including miR-34c, are decreased in cancer but increased in AD. The upstream regulatory pathways ...

Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression.

Feb 25, 2020

Later sleep timing, circadian preference, and circadian rhythm timing predict worse outcomes across multiple domains, including mood disorders, substance use, impulse control, and cognitive function. ...

Whole-exome sequencing of 81 individuals from 27 multiply affected bipolar disorder families.

Feb 25, 2020

Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of depression and mania. Research suggests that the cumulative impact of common alleles explain...

Body Mass Index Status across Different Psychiatric Disorders in a National Survey amongst Children and Adolescents: To Identify the Role of Gender.

Feb 25, 2020

Body mass index undergoes a substantial change in some psychiatric disorders. This study aimed to explore the status of body mass index (BMI) in different psychiatric disorders in a national survey a...

Demographic and Clinical Characteristics, Including Subsyndromal Symptoms Across Bipolar-Spectrum Disorders in Adolescents.

Feb 25, 2020

Bipolar disorder (BD) is a debilitating illness that often starts at an early age. Prevention of first and subsequent mood episodes, which are usually preceded by a period characterized by subthresho...

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