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Psychiatry General

Differential effects of lithium isotopes in a ketamine-induced hyperactivity model of mania.

Feb 25, 2020

Sub-anesthetic doses of ketamine produce an increase in rodent ambulation that is attenuated by co-administration of naturally-occurring lithium (LiN), the drug most commonly employed in the treatment...

Effects of perceived social status and discrimination on hope and empowerment among individuals with serious mental illnesses.

Feb 25, 2020

Hope and empowerment are key elements of recovery in the context of serious mental illnesses (SMI). We examined predictors of hope among individuals with SMI and tested a hypothesized path model in wh...

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Feb 25, 2020

CBD products have risen in popularity given CBD's therapeutic potential and lack of legal oversight, despite lacking conclusive scientific evidence for widespread over-the-counter usage for many of it...

Large scale consumption monitoring of benzodiazepines and z-drugs by hair analysis.

Feb 25, 2020

Benzodiazepines (BDZ) and z-drugs belong to the most frequently prescribed medicines worldwide used for anxiety, epilepsy and sleeping disorders. Due to their pharmacology, they have a high potential ...

Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease.

Feb 25, 2020

Non-motor symptoms (NMS) are common in Parkinson's disease (PD), but their relationships to nigrostriatal degeneration remain largely unexplored.We evaluated 18 NMS scores covering 5 major domains in ...

Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications.

Feb 25, 2020

The clinical features and implications of dizziness in patients with Parkinson's disease (PD) remain little known. This study aimed to investigate the clinical characteristics of dizziness, and the as...

Weighty choices: selecting optimal G-CSF doses for stem cell mobilization to optimize yield.

Feb 25, 2020

There are limited data on the effect of donor body mass index (BMI) on peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF), especially in unrelated...

Amplitude of low-frequency fluctuation of resting-state fMRI in primary nocturnal enuresis and attention deficit hyperactivity disorder.

Feb 25, 2020

Children with attention deficit hyperactivity disorder (ADHD) and nocturnal enuresis (NE) have similar symptoms e.g. inattention and dysfunction of working memory. We investigate disorder-specific abn...

AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics.

Feb 25, 2020

AMP-activated protein kinase (AMPK) is an important energy sensor located in cells throughout the human body. From the periphery, AMPK is known to be a metabolic master switch controlling the use of e...

A unified framework for assessing the readiness of European Union economies to migrate to a circular modelling.

Feb 25, 2020

Sustainable development demands radical rethinking of national economies, now mainly based on a linear approach. The transition to a circular one requires crucial innovations and disruptive changes an...

Conversion of MDF wastes into a char with remarkable potential to remove Food Red 17 dye from aqueous effluents.

Feb 25, 2020

Medium density fiberboard (MDF) wastes were converted into an efficient char able to uptake Food Red 17 dye (FR17) from colored effluents. The yield of the pyrolysis process, in terms of char, was 29%...

A Multi-Centered Case Series Highlighting the Clinical Use and Dosing of Lidocaine and Mexiletine for Refractory Cancer Pain.

Feb 25, 2020

Lidocaine infusion for pain control has been used for years. While some centers transition from continuous infusion lidocaine to oral mexiletine, there are no published studies to guide this conversio...

Law, Culture, and Fear: A Qualitative Study of Health Professionals' Perceptions of Narcotic Use Related to Cancer Pain.

Feb 25, 2020

Studies have shown barriers to appropriate narcotic use in the Middle East have negatively impacted patient outcomes. This study aimed to explore health professionals' perspectives regarding opioid us...

Prenatal Substance Use Disorders and Dental Caries in Children.

Feb 25, 2020

Substance use is common in women of reproductive age, but limited data exist on the dental health of their children, including risk of caries. We conducted a longitudinal cohort study of 790,758 infan...

Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives.

Feb 25, 2020

Morphine and its derivatives play inevitably important role in the μ-opioid receptor (MOR) targeted antinociception. A structure-activity relationship study is presented for novel and known orvinol a...

microRNA-422a Inhibits DCC Expression in a Manner Dependent on SNP rs12607853.

Feb 25, 2020

DCC netrin 1 receptor (DCC) affects the structure and function of the dopamine circuitry, which in turn affects the susceptibility to developing addiction. In a previous study, we found that single nu...

Asthma-Related ED Visits in Children With Depression & Anxiety

Feb 21, 2020

Research indicates that adults with asthma as well as depression, anxiety, or both demonstrate higher asthma-related healthcare use, including emergency department (ED) visits. Naomi S. Bardach, MD, M...

Prescription Medications Can Be Found on Craigslist

Feb 19, 2020

WEDNESDAY, Feb. 19, 2020 (HealthDay News) -- Prescription medications, especially analog insulin, can be found on Craigslist, according to a research letter published online Feb. 17 in JAMA Internal M...

Daytime sleep state misperception in a tertiary sleep centre population.

Feb 18, 2020

Sleep state misperception is common in various sleep disorders, especially in chronic insomnia with a prevalence ranging between 9-50%. Most prior studies used nocturnal polysomnography (PSG) for the ...

Sex differences in factors associated with daytime sleepiness and insomnia symptoms in persons with epilepsy.

Feb 18, 2020

Clinical factors associated with daytime sleepiness and insomnia in persons with epilepsy (PWE) were examined in this cross-sectional study of 126 participants (men, 50.8%). Excessive daytime sleepine...

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