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Psychiatry General

An Investigation of Psychosis Subgroups With Prognostic Validation and Exploration of Genetic Underpinnings: The PsyCourse Study.

Feb 13, 2020

Identifying psychosis subgroups could improve clinical and research precision. Research has focused on symptom subgroups, but there is a need to consider a broader clinical spectrum, disentangle illne...

Psychotic Experiences Are Associated With Paternal Age But Not With Delayed Fatherhood in a Large, Multinational, Community Sample.

Feb 13, 2020

Advanced paternal age has been consistently associated with an increased risk of schizophrenia. It is less known if such an association also exists with subclinical/attenuated forms of psychosis. Addi...

Birth weight, family history of diabetes and diabetes onset in schizophrenia.

Feb 13, 2020

The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation.To test if abnormal b...

Anomalies in language as a biomarker for schizophrenia.

Feb 13, 2020

After more than a century of neuroscience research, reproducible, clinically relevant biomarkers for schizophrenia have not yet been established. This article reviews current advances in evaluating th...

Impact of Cooling on Lowering the Pain Threshold in Patients Undergoing Sclerotherapy.

Feb 13, 2020

Liquid sclerotherapy is the treatment of choice for telangiectasias. However, pain caused by the procedure is a barrier to treatment adherence by patients.To evaluate the use of skin cooling for the m...

A novel tool showing that perceptions of adverse social relationships in childhood were linked with mental health problems and suicidal experiences: Validation of the English version of the History of Social Punishment (HoSP) scale.

Feb 13, 2020

There is robust evidence for relationships between adverse events experienced in childhood and mental health problems experienced as an adult. However, the measurement of perceptions of different type...

Analyzing the co-localization of substantia nigra hyper-echogenicities and iron accumulation in Parkinson's disease: A multi-modal atlas study with transcranial ultrasound and MRI.

Feb 13, 2020

Transcranial B-mode sonography (TCS) can detect hyperechogenic speckles in the area of the substantia nigra (SN) in Parkinson's disease (PD). These speckles correlate with iron accumulation in the SN ...

Effects of CST3 Gene G73A Polymorphism on Cystatin C in a Prospective Multiethnic Cohort Study.

Feb 13, 2020

G73A polymorphism in the CST3 gene of cystatin C has been associated with Alzheimer's disease, age-related macular degeneration, and cardiovascular disease. However, studies investigating the influenc...

Novel tau filament fold in corticobasal degeneration.

Feb 13, 2020

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy that is characterised by motor and cognitive disturbances. A higher frequency of the H1 haplotype of MAPT, the tau gene, is present in ...

Validity and characteristics of patient-evaluated adherence to medication via smartphones in patients with bipolar disorder: exploratory reanalyses on pooled data from the MONARCA I and II trials.

Feb 13, 2020

Non-adherence to medication is associated with increased risk of relapse in patients with bipolar disorder (BD).To (1) validate patient-evaluated adherence to medication measured via smartphones again...

Complex Combination Pharmacotherapy for Bipolar Disorder: Knowing When Less Is More or More Is Better.

Feb 13, 2020

Combination pharmacotherapy for bipolar disorder is commonplace and often reflects the severity and complexity of the illness and the comorbid conditions frequently associated with it. Across treatmen...

Opposing Changes in the Functional Architecture of Large-Scale Networks in Bipolar Mania and Depression.

Feb 13, 2020

Manic and depressive phases of bipolar disorder (BD) show opposite symptoms in psychomotor, thought, and affective dimensions. Neuronally, these may depend on distinct patterns of alterations in the f...

The Mental Health Crisis Among Teens

Feb 13, 2020

The first signs of a problem started to emerge around 2014: More young people said they felt overwhelmed and depressed in national surveys. College counseling centers reported sharp increases in the n...

Case report: manic episode with psychotic symptoms induced by hyponatremia.

Feb 13, 2020

In the literature, several cases of an association between hyponatremia and psychotic symptoms have been reported. We present the case of a young Caucasian male presenting with rapid, incoherent spee...

LSD Overdoses: Three Case Reports.

Feb 13, 2020

In academic settings around the world, there is a resurgence of interest in using psychedelic substances for the treatment of addictions, posttraumatic stress disorder, depression, anxiety, and other ...

Comparison of Rhinoplasty Patients Informed With Standard Verbal Information in Preoperative Period and Rhinoplasty Patients Informed and Treated With Visual Information Through Catalog in Terms of the Development of Agitation, Edema and Ecchymose in the Postoperative Period.

Feb 13, 2020

In this study, we aimed to compare the effects of standard verbal information in the preoperative period and the information by visual expression and physical applications in the development of agitat...

Identification of TNFA influencing MDD risk and clinical features in Han Chinese.

Feb 13, 2020

Our recent genetic-neuroimaging study observed that the rs1799724 polymorphism within the TNFA gene encoding TNF-α selectively affects the anatomy of visual cortex in patients with MDD. In this study...

Kellner's Symptom Questionnaire, a Highly Sensitive Patient-Reported Outcome Measure: Systematic Review of Clinimetric Properties.

Feb 13, 2020

Patient-reported outcomes (PROs) are of increasing importance in clinical medicine. However, their evaluation by classic psychometric methods carries considerable limitations. The clinimetric approach...

Prospective 3-arm study on pain and epithelial healing after corneal crosslinking.

Feb 13, 2020

To investigate the effect of 3 regimes on pain and wound healing after corneal crosslinking (CXL).Tertiary academic referral center, Utrecht, the Netherlands.Prospective cohort study.Consecutive progr...

Specific cognitive correlates of the quality of life of extremely preterm school-aged children without major neurodevelopmental disability.

Feb 13, 2020

We examined how specific cognitive behavioral impairments impacted quality of life (QoL) within a large multicenter cohort of 7-10 year olds surviving extremely preterm (EPT) without major neurodevelo...

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