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Psychiatry General

Dietary Theobromine and the Incidence of Depression

Dec 21, 2022

The following is a summary of the “Association between dietary theobromine with depression: a population-based study" published in the December 2022 issue of Psychiatry by Li et al. The objec...

Ethical, legal, and social implications of genetic risk prediction for multifactorial disease: a narrative review identifying concerns about interpretation and use of polygenic scores.

Dec 19, 2022

Advances in genomics have enabled the development of polygenic scores (PGS), sometimes called polygenic risk scores, in the context of multifactorial diseases and disorders such as cancer, cardiovascu...

Gabapentinoids for Pain: A Review of Published Comparative Effectiveness Trials and Data Submitted to the FDA for Approval.

Dec 19, 2022

Use of the gabapentinoids for pain continues to increase. In 2018, the US Food and Drug Administration (FDA) strengthened the warnings for both gabapentin and pregabalin to emphasize the central nervo...

Probiotic supplementation improved cognitive function in cognitively impaired and healthy older adults: a systematic review of recent trials.

Dec 19, 2022

Recent evidence suggests that there is clear association between microbiota and cognitive functioning, which is known as microbiome-gut-brain axis. Probiotic bacteria consumption can alter human micro...

Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer's disease.

Dec 19, 2022

The long-lived Chilean rodent (Octodon degus) has been reported to show spontaneous age-dependent neuropathology and cognitive impairments similar to those observed in human AD. However, the handful o...

Circulating endothelial progenitor cell dysfunction in patients with bipolar disorder.

Dec 19, 2022

Dysfunction in circulating endothelial progenitor cells (cEPCs) plays a crucial role in cardiovascular disorders (CVDs). Patients with bipolar disorder (BPD) are at increased risk of developing CVDs. ...

Mindful eating for weight loss in women with obesity: a randomized controlled trial.

Dec 19, 2022

Mindful eating has been linked to improvement in binge eating disorder, but this approach in obesity management has shown conflicting results. Our aim was to assess the effect of mindful eating associ...

Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000-2018.

Dec 19, 2022

Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on t...

Mass Violence and the Complex Spectrum of Mental Illness and Mental Functioning.

Dec 19, 2022

Psychiatry has struggled to clarify the types of mental turmoil that are associated with mass violence. While the problem is complex, it may present an opportunity to improve research, as well as info...

Variations in the Risk of Death with Substance Use Disorder

Dec 15, 2022

The following is a summary of the “Patterns of mortality risk among patients with substance use disorder: an opportunity for proactive patient safety?" published in the December 2022 issue of Psychi...

SCOPE for Infants and Toddlers at Risk for ASD

Dec 15, 2022

The following is a summary of the Social COmmunication Program supported by E-health (SCOPE) for infants and toddlers at the elevated likelihood of autism spectrum disorder: study design of a cluster ...

Case Study on Pervasive Prenatal Denial

Dec 15, 2022

The following is a summary of "A case report involving the experience of pervasive pregnancy denial: detailed observation of the first 12 postpartum weeks" published in the December 2022 issue of Psyc...

A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life through Reduction of Serotonin Levels and Its Urinary Metabolites.

Dec 12, 2022

(1). An essential component of any treatment for patients with irritable bowel syndrome (IBS) is an adequate diet. Currently, a low FODMAP diet is recommended as a first-line therapy, but it does not ...

Fall Risk, Sleep Behavior, and Sleep-Related Movement Disorders in Young Urbanites Exposed to Air Pollution.

Dec 12, 2022

Quadruple aberrant hyperphosphorylated tau, amyloid-β, α-synuclein, and TDP-43 pathology had been documented in 202/203 forensic autopsies in Metropolitan Mexico City ≤40-year-olds with high expos...

The Role of D-Serine and D-Aspartate in the Pathogenesis and Therapy of Treatment-Resistant Schizophrenia.

Dec 12, 2022

Schizophrenia (Sch) is a severe and widespread mental disorder. Antipsychotics (APs) of the first and new generations as the first-line treatment of Sch are not effective in about a third of cases and...

Transcriptomics and metabolomics together reveal the underlying mechanism of heroin hepatotoxicity.

Dec 12, 2022

Researches on heroin are more about addiction and some infectious diseases it causes, but liver fibrosis caused by heroin abuse and the mechanism of heroin hepatotoxicity in addicts are ignored. To ex...

The effects of pregnancy-related Medicaid expansions on maternal, infant, and child health.

Dec 12, 2022

Prior research has examined how late 1980s pregnancy-related Medicaid eligibility expansions influenced outcomes around the time of birth and, more recently, adult outcomes. We offer a close examinati...

ZBTB20-AS1 promoted Alzheimer's disease progression through ZBTB20/GSK-3β/Tau pathway.

Dec 12, 2022

To elucidate the potential molecular mechanisms of ZBTB20-AS1 on ZBTB20 and GSK-3β/Tau signaling pathway in the pathogenesis of Alzheimer's disease (AD), SH-SY5Y cells were obtained for in vitro exp...

Altered patterns of central executive, default mode and salience network activity and connectivity are associated with current and future depression risk in two independent young adult samples.

Dec 12, 2022

Neural markers of pathophysiological processes underlying the dimension of subsyndromal-syndromal-level depression severity can provide objective, biologically informed targets for novel interventions...

Karl Grassmann's 1896 paper "critical overview of contemporary theories of the heredity of the psychoses".

Dec 12, 2022

Four years before the rediscovery of Mendel's work in 1900, Karl Grassmann published a detailed, scholarly review of the heredity of psychosis which we here review. A full translation is in the append...

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