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Psychiatry General

Continuum beliefs and the perception of similarities and differences to a person with depression.

May 02, 2022

Both continuum beliefs (i.e., that mental disorder exists on a spectrum of normative behavior patterns) and the perception of similarities to a person with schizophrenia have shown mixed effects on re...

A Systematic Review of the Effectiveness and Safety of Droperidol for Pediatric Agitation in Acute Care Settings.

May 02, 2022

Agitation in children in acute care settings poses significant patient and staff safety concerns. While behavioral approaches are central to reducing agitation and oral medications are preferred, pare...

Associations of presenting symptoms and subsequent adverse clinical outcomes in people with unipolar depression: a prospective natural language processing (NLP), transdiagnostic, network analysis of electronic health record (EHR) data.

May 02, 2022

To investigate the associations of symptoms of mania and depression with clinical outcomes in people with unipolar depression.A natural language processing electronic health record study. We used netw...

Exploring reasons for MD-PhD trainees' experiences of impostor phenomenon.

May 02, 2022

Acceptance into U.S. MD-PhD dual-degree programs is highly competitive, and the lengthy training program requires transitioning between multiple phases (pre-clinical-, PhD-research-, and clinical-trai...

Factors that influence the emotional impact of memory problems in older adults: A qualitative descriptive study.

May 02, 2022

Associations among psychological health and memory concerns in older adults are well-established, but much of this research is quantitative.This study examined how memory problems influence emotional ...

Deep Learning Identifies Robust Gender Differences in Functional Brain Organisation & Their Dissociable Links to Clinical Symptoms in Autism

Apr 29, 2022

Autism spectrum disorder (ASD) is a disorder with a wide range of symptoms that affects almost one in every 189 girls and one in every 42 boys. For a study, the researchers sought to find reliable fun...

Differential Potency of Antidepressants to Inhibit Serotonin & Norepinephrine Reuptake

Apr 25, 2022

Venlafaxine is a dual inhibitor of serotonin (5-HT) and norepinephrine reuptake. The precise dosage at which it begins to efficiently activate the norepinephrine transporter (NET) was unknown. Paroxet...

Relationship Between Dissociation & Antidepressant Effects of Esketamine Nasal Spray in TRD Patients

Apr 25, 2022

Data from two positive, pivotal, phase 3 trials of esketamine nasal spray (ESK) in treatment-resistant depression (TRD)—a short-term study (TRANSFORM-2) and a maintenance study (SUSTAIN-1)—were an...

Benzodiazepine & Z-Drug Use & the Risk of Developing Dementia

Apr 25, 2022

Benzodiazepine (BZDs) and Z-drugs (BZDRs) are among the most commonly given pharmaceuticals for anxiety and sleeplessness, particularly among the elderly. For a study, researchers sought to determine ...

Cognitive insight in individuals at ultra-high risk for psychosis compared to patients with first-episode psychosis and non-psychotic help-seeking youths.

Apr 25, 2022

Defective insight is a hallmark of schizophrenia. Less is known about insight in emerging psychosis. In this study a widely used measure of cognitive insight, the Beck Cognitive Insight Scale (BCIS), ...

Visual Event-Related Potentials under External Emotional Stimuli in Bipolar I Disorder with and without Hypersexuality.

Apr 25, 2022

Hypersexuality is related to functions of personality and emotion and is a salient symptom of bipolar I disorder especially during manic episode. However, it is uncertain whether bipolar I disorder wi...

Antidepressant Treatment and Manic Switch in Bipolar I Disorder: A Clinical and Molecular Genetic Study.

Apr 25, 2022

Affective switch is an important clinical issue when treating bipolar disorder. Though commonly seen in clinical practice, the benefits of prescribing antidepressants for bipolar depression are still ...

Depressive symptom trajectories and polygenic risk scores in individuals with an immune-mediated inflammatory disease.

Apr 25, 2022

To develop group-based trajectories of depressive symptoms in immune-mediated inflammatory disease (IMID) to understand their evolution and identify any associated factors, with the overall goal of id...

Community-Based Social Interventions For People With Severe Mental illness (SMI)

Apr 20, 2022

People who suffer from severe mental illness (SMI) are one of society's most stigmatized groups. Clinicians, policymakers, and persons with SMI themselves all value interventions that attempt to promo...

Cross-disorder and disorder-specific deficits in social functioning among schizophrenia and alzheimer's disease patients.

Apr 18, 2022

Social functioning is often impaired in schizophrenia (SZ) and Alzheimer's disease (AD). However, commonalities and differences in social dysfunction among these patient groups remain elusive.Using da...

Phase 3b Multicenter, Prospective, Open-label Trial to Evaluate the Effects of a Digital Medicine System on Inpatient Psychiatric Hospitalization Rates for Adults With Schizophrenia.

Apr 18, 2022

Inpatient psychiatric admissions drive the financial burden of schizophrenia, and medication adherence remains challenging. We assessed whether aripiprazole tablets with sensor (AS; system includes i...

Speech Understanding in Manic and Depressive Episodes of Mood Disorders.

Apr 18, 2022

The aim of this study was to assess the perception of speech in adverse acoustic conditions during manic and depressive episodes of mood disorders.Forty-three patients with bipolar disorder (mania, N=...

Metabolic effects of adding Topiramate on Aripiprazole in bipolar patients aged between 6-18 years, a randomized, double-blind, placebo-controlled trial.

Apr 18, 2022

second-generation antipsychotics (SGAs) are associated with metabolic side effects in child and adolescents. The aim of this study is to evaluate the metabolic effects of adding topiramate on aripipra...

Comparing retinal changes measured by optical coherence tomography in patients with schizophrenia and their siblings with healthy controls: Are retinal findings potential endophenotype candidates?

Apr 11, 2022

The aim of our study is to examine whether differences in retinal structure may reflect endophenotypes for schizophrenia by comparing thicknesses of retinal layers between patients with schizophrenia,...

SSPNet: An interpretable 3D-CNN for classification of schizophrenia using phase maps of resting-state complex-valued fMRI data.

Apr 11, 2022

Convolutional neural networks (CNNs) have shown promising results in classifying individuals with mental disorders such as schizophrenia using resting-state fMRI data. However, complex-valued fMRI dat...

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