Apr 04, 2022

Exposure to adverse childhood experiences (ACEs) is linked to disruptions in typical neurodevelopment of brain structures and functioning, including changes in executive functions. Although the relati...

Apr 04, 2022

Clinical interviews and laboratory-based emotional induction paradigms provide consistent evidence that facial affect is blunted in many individuals with schizophrenia. Although it is clear that blunt...

Apr 04, 2022

Despite high co-morbidity between premenstrual dysphoric disorder and mood disorders, there is a gap of research-based tools to monitor concurrent premenstrual and mood symptoms. In this study, we dev...

Apr 04, 2022

Bipolar depression is a leading cause of morbidity in patients with bipolar disorder (BD) with at least half of bipolar patients who initially present with a depressive episode. While several pharmaco...

Apr 04, 2022

Electroconvulsive therapy (ECT) is the most effective non-pharmacological treatment for treatment-resistant depression (TRD) but can expose to transient cognitive impairments. Understanding factors un...

Apr 04, 2022

Examine how specific types of childhood adversity are associated with clinical features and treatment in adults with Major Depressive Disorder (MDD).This is a secondary analysis of the 35-site VA Augm...

Mar 29, 2022

For a study, researchers sought to compare two low-intensity outreach programs with standard treatment to prevent suicidal conduct in outpatients who have recently had frequent suicidal thoughts. Outp...

Mar 28, 2022

Vitamin B12 deficiency can have distressing neuropsychiatric symptoms. It can have an etiological role in clinical presentations like depression, anxiety, psychosis, dementia, and delirium, requiring ...

Mar 28, 2022

Stress is a major risk factor for the development of both schizophrenia and depression, and comorbidity between the two is common in schizoaffective disorders. However, the effects of stress exposure ...

Mar 28, 2022

This article provides an overview and retrospective on metacognitive training for psychosis (MCT), which first appeared approximately 2 decades ago. We recount how our empirical understanding of psych...

Mar 28, 2022

Gut microbiota has emerged as a crucial target of gut-brain axis to influence depression. Zhi-Zi-Chi decoctions (ZZCD), as a classic oral formula in clinic, is widely applied in depression treatment n...

Mar 28, 2022

Western psychiatry emerged as a medical specialty caring for the mentally ill over the course of the late 18th and early 19th centuries. This emergence was a contingent process, dependent on the co-oc...

Mar 28, 2022

Cariprazine is a piperazine derivative approved by the USFDA in 2015 as a novel atypical antipsychotic drug (APD) to treat adults with schizophrenia and bipolar manic or mixed episodes in adults. Howe...

Mar 28, 2022

Children who are exposed to parental substance use disorder (SUD) have a higher risk of SUD themselves. This study examines the extent to which the association between parental and own SUD is conditio...

Mar 28, 2022

The purpose of this study was to determine the test-retest reliability and construct validity of tools to assess how balance confidence (BC) and state anxiety (SA) change with progressively increasing...

Mar 24, 2022

TP0473292 (the active component in TS-161) is a prodrug of new metabotropic glutamate (mGlu) 2/3 receptor antagonist that was being investigated for the treatment of depression patients. The safety, t...

Mar 23, 2022

Cognitive improvement following antipsychotic drugs appears to require redox modulation via neurotrophins such as a brain-derived neurotrophic factor in people with schizophrenia (SCZ) (BDNF). For a s...

Mar 23, 2022

The mechanisms through which kappa opioid receptor (KOR) agonists generate psychotomimetic effects are largely unclear, despite the fact that manipulation of this receptor has sparked interest for the...

Mar 23, 2022

Depression and suicidal conduct have both been linked to the serotonin 1A (5-HT1A) receptor. Lower resting cortisol levels are connected with increased 5-HT1A receptor binding, and both distinguish su...

Mar 23, 2022

Inattention deficit hyperactivity disorder (ADHD), a high placebo response can minimize medication–placebo differences, compromising the development of novel medications. For a study, researchers so...