Mar 24, 2022

TP0473292 (the active component in TS-161) is a prodrug of new metabotropic glutamate (mGlu) 2/3 receptor antagonist that was being investigated for the treatment of depression patients. The safety, t...

Mar 23, 2022

Cognitive improvement following antipsychotic drugs appears to require redox modulation via neurotrophins such as a brain-derived neurotrophic factor in people with schizophrenia (SCZ) (BDNF). For a s...

Mar 23, 2022

The mechanisms through which kappa opioid receptor (KOR) agonists generate psychotomimetic effects are largely unclear, despite the fact that manipulation of this receptor has sparked interest for the...

Mar 23, 2022

Depression and suicidal conduct have both been linked to the serotonin 1A (5-HT1A) receptor. Lower resting cortisol levels are connected with increased 5-HT1A receptor binding, and both distinguish su...

Mar 23, 2022

Inattention deficit hyperactivity disorder (ADHD), a high placebo response can minimize medication–placebo differences, compromising the development of novel medications. For a study, researchers so...

Mar 23, 2022

Energy drinks (EDs) increase driving performance while decreasing drowsiness and exhaustion, but alcohol has the reverse effect. Although it is a popular combination among young people, the consequenc...

Mar 23, 2022

As senior people's life expectancy has increased, so has the prevalence of cardiovascular and cerebrovascular disorders in this demographic. All kinds of cognitive problems related to cerebrovascular ...

Mar 23, 2022

For a study, it was determined that the neuropathology of bipolar disease (BD) was linked to oxidative stress. Single-nucleotide polymorphisms (SNPs) in the antioxidative genes superoxide dismutase 2 ...

Mar 22, 2022

Evidence showed that neuroaxonal damage was linked to a major depressive illness and that neurofilament light chain (NFL) is a biomarker of neuroaxonal injury. Furthermore, proinflammatory cytokines w...

Mar 22, 2022

The extended-release pill ansofaxine (LY03005) is a possible triple reuptake inhibitor of serotonin, norepinephrine, and dopamine. For a study, researchers examined the effectiveness, safety, and dose...

Mar 22, 2022

For a randomized, double-blind (DB), parallel-group research, investigators sought to compare the effectiveness and safety of paliperidone palmitate 6-month (PP6M) formulation to paliperidone palmitat...

Mar 22, 2022

Previous animal and human research suggested that stress regulating systems such as the hypothalamic-pituitary-adrenal (HPA) axis and the endocannabinoid (ECB) system might play a role in the developm...

Mar 22, 2022

The most common mental condition in children with 22q11.2 deletion syndrome (22q11DS) is attention deficit and/or hyperactivity disorder (ADHD), which commonly continues into adulthood. Although stimu...

Mar 22, 2022

Suicide is a worldwide public health concern. However, there were no objective biomarkers of suicide risk, and self-reported data might be incorrect, limiting prediction, diagnostic, and therapy effor...

Mar 22, 2022

Astrocytes and microglia have a role in the pathophysiology of epilepsy and bipolar illness, and their involvement is linked to inflammation. For a study, researchers sought to examine how the antiepi...

Mar 14, 2022

Insomnia is common among older adults and associated with an increased risk for falls. Determining if falls are more strongly associated with insomnia or prescribed hypnotic medications could be used ...

Mar 14, 2022

"Lock-in" programs are used by health insurers to reduce the risk of adverse outcomes that can result from overutilization of opioids and other controlled substances. We estimated the association betw...

Mar 14, 2022

"Lock-in" programs are used by health insurers to reduce the risk of adverse outcomes that can result from overutilization of opioids and other controlled substances. We estimated the association betw...

Mar 14, 2022

Evidence for the treatment of bipolar affective disorder with cognitive analytic therapy (CAT) is limited, and so this study sought to intensively evaluate outcomes in a co-produced single-case experi...

Mar 14, 2022

"Lock-in" programs are used by health insurers to reduce the risk of adverse outcomes that can result from overutilization of opioids and other controlled substances. We estimated the association betw...