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Psychiatry General

Oxcarbazepine versus sodium valproate in treatment of acute mania: a double-blind randomized clinical trial.

Feb 07, 2022

Oxcarbazepine as an anticonvulsant has been suggested as an effective drug in affective disorders. The present study was designed to compare the efficacy of oxcarbazepine and sodium valproate in the t...

Adverse Childhood Experiences Linked With Dementia Risk in Older Adults

Feb 02, 2022

Adverse childhood experiences (ACEs) are associated with a greater risk for many common conditions that contribute to mortality in adulthood, but limited evidence examines whether ACEs correlate with ...

Prevalence, incidence, and health care utilization of patients with narcolepsy: a population-representative study.

Jan 31, 2022

Previous estimated prevalence of narcolepsy in Europe was 47 patients per 100,000 persons, with a yearly incidence of 0.64-1.37 per 100,000. However, analyses of representative datasets from large coh...

N-Acetylcysteine as a novel rapidly acting anti-suicidal agent: A pilot naturalistic study in the emergency setting.

Jan 31, 2022

N-acetylcysteine has a demonstrated role as an adjunctive therapy in psychotic and affective disorders as a treatment to reduce symptoms of Bipolar Affective Disorder, Major Depressive Disorder and Sc...

Stress predicts depression symptoms for women living with bipolar disorder during the menopause transition.

Jan 31, 2022

Although sleep disturbance is an important feature in bipolar disorder, the relationship between mood symptoms, sleep disturbances, and hot flash symptom severity during menopause for women with bipol...

The role of mtDNA haplogroups on metabolic features in narcolepsy type 1.

Jan 24, 2022

Narcolepsy type 1 (NT1) is due to selective loss of hypocretin (hcrt)-producing-neurons. Hcrt is a neuropeptide regulating the sleep/wake cycle, as well as feeding behavior. A subset of NT1 patients b...

Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity.

Jan 24, 2022

N-Methyl-d-aspartate receptors (NMDARs) are members of the ionotropic glutamate receptor family and play a crucial role in learning and memory by regulating synaptic plasticity. Activation of NMDARs c...

The association between objective necessity for involuntary treatment as measured during admission, legal admission status and clinical factors in an inpatient psychiatry setting.

Jan 24, 2022

Involuntary psychiatric admission is a common feature of mental health services around the world, but there is limited research about tools to support clinical assessment of objective necessity for co...

Volunteering Improves Employee Health and Organizational Outcomes through Bonding with Coworkers and Enhanced Identification with Employers.

Jan 24, 2022

To understand the determinants and consequences of employee volunteering and possible psychological mechanisms that produce these effects.Using data from more than 50,000 responses to Britain's Health...

Rapid cycling bipolar disorder: Literature review on pharmacological treatment illustrated by a case report on ketamine.

Jan 24, 2022

Rapid cycling bipolar disorder (RCBD) is defined as four or more affective episodes (depression, mania or hypomania) within 1 year. RCBD has a high point of prevalence (from 10% to 20% among clinical ...

Effect of blueberry extract on energetic metabolism, levels of brain-derived neurotrophic factor, and Ca-ATPase activity in the hippocampus and cerebral cortex of rats submitted to ketamine-induced mania-like behavior.

Jan 24, 2022

Bipolar disorder (BD) is a psychiatric disease characterized by mood episodes. Blueberry is rich in bioactive compounds and shows excellent therapeutic potential against chronic diseases. The aim of t...

Mental Health Disorders and Suicidal Behaviors Among Provincial Correctional Workers.

Jan 24, 2022

We examined the prevalence of mental health disorders and suicidal behaviours (ideation, planning and attempts) among a sample of provincial correctional workers in Manitoba.Self-reported mental healt...

Tourette Disorder and Sleep.

Jan 17, 2022

Healthy sleep is of utmost importance for growth, development, and overall health. Strong evidence shows that sleep is affected negatively in patients and particularly children with Tourette Disorder ...

Long-term safety and effectiveness of open-label lurasidone in antipsychotic-Naïve versus previously treated adolescents with Schizophrenia: A post-hoc analysis.

Jan 17, 2022

There is a relative lack of long-term, prospective data evaluating the safety and effectiveness of treatment in early-onset adolescent patients with schizophrenia who are treatment-naïve. The aim of ...

Outcomes for first-episode psychosis after entry via an at-risk mental state clinic compared to direct entry to a first episode of psychosis service: A systematic review and meta-analysis.

Jan 17, 2022

Early intervention for psychosis services have been established worldwide and consist of specialist services for those with the At-Risk Mental State (ARMS) and a first episode of psychosis (FEP). This...

Computational modelling of the speed-accuracy tradeoff: No evidence for an association with depression symptomatology.

Jan 17, 2022

Successful decision making often requires finding the right balance between the speed and accuracy of responding: Emphasising speed can lead to error-prone performance, yet emphasising accuracy leads ...

Schema Therapy for Patients with Bipolar Disorder: Theoretical Framework and Application.

Jan 17, 2022

Bipolar disorder (BD) is a severe mood disorder characterized by episodes of depression and hypomania or mania. Despite its primarily biological roots, the onset and course of the disorder have also b...

Neurocysticercosis presenting as bipolar disorder: a case report.

Jan 17, 2022

Neurocysticercosis is the most common neuro-parasitosis caused by the larval stage of . The most common manifestations include seizures and hydrocephalus. Psychiatric abnormalities are relatively rare...

Psychosocial treatment on psychological symptoms, adherence, and physiological function on transplanted patients: A systematic review and metanalysis.

Jan 17, 2022

Transplantation represents an important source of hope for the candidates and produces an intense emotional effect. Psychosocial interventions can be helpful in all transplantation stages to better ma...

Combined influence of medication and symptom severity on visual processing in bipolar disorder.

Jan 17, 2022

Previous studies have reported visual impairments in patients with bipolar disorder (BPD), but unclear were whether clinical variables would be associated with those disturbances. Here, we investigate...

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