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Psychiatry General

Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review.

Oct 18, 2021

Bipolar disorder (BD) is a cyclic mood disorder characterised by alternating episodes of mania/hypomania and depression interspersed with euthymic periods. Lamotrigine (LTG) demonstrated some mood imp...

Isotretinoin Induced Psychotic Mania: A Case Report.

Oct 18, 2021

Biological, genetic and psychosocial factors may play a role in the aetiology of bipolar mood disorder (BPD). BPD episodes might be triggered by isotretinoin, a retinoid derivative of vitamin A with a...

Inflammation mediates depression and generalized anxiety symptoms predicting executive function impairment after 18 years.

Oct 18, 2021

Scar theories propose that elevated depression and anxiety can predispose people to future decreased executive function (EF) via heightened inflammation across decades. However, more longitudinal (ver...

Depression Linked With Risks of Vascular Disease & Mortality in MS

Oct 11, 2021

“Depression is the most frequent comorbidity for people with MS, affecting more than 20% of this patient population,” explains Raffaele Palladino, MD, PhD. “In addition, depression is associated...

Receptor density influences ligand-induced dopamine D receptor homodimerization.

Oct 11, 2021

Chronic treatments with dopamine D2 receptor ligands induce fluctuations in D2 receptor density. Since D2 receptors tend to assemble as homodimers, we hypothesized that receptor density might influenc...

Why cultural ecosystem services matter most: Exploring the pathways linking greenspaces and mental health in a low-income country.

Oct 11, 2021

Exposure to urban greenspaces promotes a variety of mental health benefits. However, much of the evidence for these benefits is biased towards high-income countries. In contrast, urban areas in low-in...

Psychiatric sequelae of stroke affecting the non-dominant cerebral hemisphere.

Oct 11, 2021

There are a plethora of cognitive sequelae in addition to neglect and extinction that arise with unilateral right hemispheric stroke (RHS). Cognitive deficits following non-dominant (right) hemisphere...

Mental contamination, disgust, and other negative emotions among survivors of sexual trauma: Results from a daily monitoring study.

Oct 11, 2021

Mental contamination (MC)-feelings of dirtiness triggered by internal sources-is a potentially important yet understudied factor for survivors of sexual trauma. MC has been linked to disgust and other...

Early illness progression in mood disorders: A population-based longitudinal study.

Oct 11, 2021

This study is aimed at assessing changes in functioning among young people from the general population with bipolar disorder and major depressive disorder over a period of five years. Specifically, we...

Addressing Structural Racism in Psychiatry With Steps to Improve Psychophysiologic Research.

Oct 11, 2021

The American Medical Association has acknowledged the public health threat posed by racism in medicine. While clinicians in psychiatry have echoed the sentiment, the research community has largely bee...

Prevalence and correlates of restless legs syndrome in men living with HIV.

Oct 04, 2021

Data on the prevalence and correlates of restless legs syndrome (RLS) in people with HIV are limited. This study sought to determine the prevalence of RLS, associated clinical correlates, and characte...

Glial fibrillary acidic protein as blood biomarker for differential diagnosis and severity of major depressive disorder.

Oct 04, 2021

Neuroinflammation has been connected to the pathophysiology of major depressive disorder (MDD) and neurochemical biomarkers of glial pathology could aid the diagnosis and might support patient stratif...

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations.

Oct 04, 2021

The 2018 Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) guidelines provided clinicians with pragmatic treatment recommendations for bi...

Default mode network shows alterations for low-frequency fMRI fluctuations in euthymic bipolar disorder.

Oct 04, 2021

Bipolar disorder (BD) is a psychiatric condition causing acute dysfunctional mood states and emotion regulation. Specific neuropsychological features are often present also among patients in euthymic ...

The effect of depression and anxiety symptom severity on clinical outcomes and app use in digital mental health treatments: Meta-regression of three trials.

Oct 04, 2021

A large number of trials have consistently shown that guided digital mental health treatments (DMHTs) are effective for depression and anxiety. As DMHTs are adopted by healthcare organizations, payers...

Mental health and behaviour in children with dystonia: Anxiety, challenging behaviour and the relationship to pain and self-esteem.

Oct 04, 2021

To ascertain whether young people with dystonia are more likely than the general population to have mental health and/or behavioural difficulties, and to explore factors that may contribute to these d...

Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761®.

Sep 27, 2021

Tinnitus is defined as the perception of sound in the absence of external acoustic stimuli. Frequent comorbidities or associated factors are depression, anxiety, concentration problems, insomnia, resi...

A word is worth a thousand pictures: A 20-year comparative analysis of aberrant abstraction in schizophrenia, affective psychosis, and non-psychotic depression.

Sep 27, 2021

thinking is a cognitive process that involves the assimilation of concepts reduced from diffuse sensory input, organized, and interpreted in a manner beyond the obvious. There are multiple facets by w...

Alteration of power law scaling of spontaneous brain activity in schizophrenia.

Sep 27, 2021

Nonlinear dynamical analysis has been used to quantify the complexity of brain signal at temporal scales. Power law scaling is a well-validated method in physics that has been used to describe the dyn...

Insecure Attachment Styles and Unbalanced Family Functioning as Risk Factors of Problematic Smartphone Use in Spanish Young Adults: A Relative Weight Analysis.

Sep 27, 2021

Young adulthood is the life stage during which people are more prone to develop problematic smartphone use (PSU). Only one study investigated the relationship among attachment styles, family functioni...

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