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Psychiatry General

Mitochondrial dysfunction in Alzheimer's disease: therapeutic implications of lithium.

Jun 24, 2021

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of abnormal tau proteins within neurons and amyloid plaques in the brain parenchyma,...

Intrusion Errors and Progression of Cognitive Deficits in Older Adults with Mild Cognitive Impairment and PreMCI States.

Jun 24, 2021

Among persons with amnestic mild cognitive impairment (aMCI), intrusion errors on subscales that measure proactive semantic interference (PSI) may be among the earliest behavioral markers of elevated ...

Residual symptoms in bipolar disorders: Findings from the bipolar Disorder course and outcome study from India (BiD-CoIN study).

Jun 24, 2021

To explore the prevalence of residual symptoms (both depressive and manic) and their correlates in subjects with bipolar disorder in clinical remission.This multicentric cross-sectional study included...

Trajectory of insight on various dimensions among bipolar disorder in-patients.

Jun 24, 2021

Insight is awareness of one's symptoms, illness, and need for treatment. In bipolar disorder, insight is better in bipolar depression and nonpsychotic depression when compared with mania and psychotic...

Using Screening Scales for Bipolar Disorder in Epidemiologic Studies: Lessons Not Yet Learned.

Jun 24, 2021

In a recent issue in the journal, Humpston, Bebbington, and Marwaha (2021) reported the results of the first large epidemiological study of bipolar disorder in England. The prevalence estimate of bipo...

Does pre-treatment functioning influence response to intravenous ketamine in adults with treatment-resistant depression?

Jun 24, 2021

The efficacy of monoamine-based antidepressants in adults with major depressive disorder (MDD) is attenuated in persons with greater pre-treatment functional impairment. Herein, we investigated whethe...

Critical Care Nurses' Physical and Mental Health, Worksite Wellness Support, and Medical Errors.

Jun 24, 2021

Critical care nurses experience higher rates of mental distress and poor health than other nurses, adversely affecting health care quality and safety. It is not known, however, how critical care nurse...

Structural Validity of the Hospital Anxiety and Depression Scale Among Family Members of Critically Ill Patients.

Jun 24, 2021

The Hospital Anxiety and Depression Scale (HADS) is commonly used clinically and scientifically among surrogate decision makers for critically ill patients. The validity of the HADS has been scrutiniz...

Innovative preclinic triage system to guide Australians to the right mental health care first time.

Jun 24, 2021

This paper presents a case study of an innovative direct-to-consumer preclinic triage system designed to reduce predicted peak demand for Australian mental health services as a result of COVID-19 and ...

Effects of a Video-Based mHealth Program for Homebound Older Adults: Study Protocol for a Pilot Randomized Controlled Trial.

Jun 24, 2021

Although homebound older adults are among the highest users of hospital services, the existing health and social services that are provided to them in the community are limited and fragmented. This st...

Examining Why Patients With Chronic Hepatitis C Drink Alcohol

Jun 23, 2021

The burden of chronic liver disease in the United States is substantial, affecting about 4.5 million American adults, according to recent data. The end result of chronic liver disease is cirrhosis, wh...

Computational models of the "active self" and its disturbances in schizophrenia.

Jun 21, 2021

The notion that self-disorders are at the root of the emergence of schizophrenia rather than a symptom of the disease, is getting more traction in the cognitive sciences. This is in line with philosop...

A population-based psychometric analysis of the insomnia severity index in black women with and without a history of cancer.

Jun 17, 2021

Black women are under-represented in insomnia research. Further, cancer treatments increase the risk of late effects, thus affecting the sleep of psychologically and medically vulnerable cancer surviv...

Reduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis.

Jun 17, 2021

Accumulating evidence points to neurophysiological abnormalities of the motor cortex in Schizophrenia (SCZ). However, whether these abnormalities represent a core biological feature of psychosis rathe...

Long range temporal correlations (LRTCs) in MEG-data during emerging psychosis: Relationship to symptoms, medication-status and clinical trajectory.

Jun 17, 2021

Long-Range Temporal Correlations (LRTCs) index the capacity of the brain to optimally process information. Previous research has shown that patients with chronic schizophrenia present altered LRTCs at...

Computational models of the "active self" and its disturbances in schizophrenia.

Jun 17, 2021

The notion that self-disorders are at the root of the emergence of schizophrenia rather than a symptom of the disease, is getting more traction in the cognitive sciences. This is in line with philosop...

Glutamine addiction in virus-infected mammalian cells: A target of the innate immune system?

Jun 17, 2021

Control of core cell metabolism is a key aspect of the evolutionary conflict between viruses and the host's defence mechanisms. From their side, the invading viruses press the accelerator on their hos...

A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder.

Jun 17, 2021

Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalized a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional,...

Effects of Cariprazine on Cognition in Patients With Bipolar Mania or Mixed States: Post Hoc Analysis From 3 Randomized, Controlled Phase III Studies.

Jun 17, 2021

Cariprazine, a dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, is approved for the treatment of schizophrenia and for depressive, manic, or mixed episodes associated with b...

Ornithine Transcarbamylase Deficiency Presenting with Symptoms of Mania in a Young Adult Male.

Jun 17, 2021

The purpose of this case study is to review the clinical presentation and medical workup of a young adult male presenting with acute behavior changes in the setting of undiagnosed ornithine transcarba...

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