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Psychiatry General

Health-related quality of life and its determinants during and after treatment for paediatric acute lymphoblastic leukaemia: a national, prospective, longitudinal study in the Netherlands.

Oct 30, 2023

Health-related quality of life (HRQoL) is impaired in paediatric patients with acute lymphoblastic leukaemia (ALL). Over the past decades, ALL treatment has successfully been adjusted to the risk of r...

Risk evaluation of diabetic ketoacidosis associated with antipsychotics among patients with schizophrenia in the Japanese adverse event report database.

Oct 23, 2023

Diabetic ketoacidosis (DKA) is a serious life-threatening condition and can be associated with antipsychotic medication. Asian patients with diabetes exhibit less insulin resistance than Caucasians; h...

Positive association of acetylcholine esterase (AChE) with the neutrophil-to-lymphocyte ratio and HbA1c, and a negative association with hydrogen sulfide (HS) levels among healthy African Americans, and HS-inhibition and high-glucose-upregulation of AChE in cultured THP1 human monocytes.

Oct 23, 2023

The incidence of Alzheimer's disease (AD) is higher in people over the age of 65 and in African Americans (AA). Elevated acetylcholinesterase (AChE) activity has been considered a major player in the ...

Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.

Oct 23, 2023

The use of adjunctive therapy for bipolar disorder is increasingly considered to increase the efficacy of standard treatments. In this randomized clinical trial, we evaluated the effect of vitamins B1...

Metabolic effects of atypical antipsychotics: Molecular targets.

Oct 23, 2023

Atypical antipsychotics (AAPs) are commonly prescribed drugs in the treatment of schizophrenia, bipolar disorder and other mental diseases with psychotic traits. Although the use of AAPs is associated...

The GluN2C/D-specific positive allosteric modulator CIQ rescues delay-induced working memory deficits in mice.

Oct 16, 2023

Working memory is of short duration and is, therefore, particularly sensitive to time delays. Moreover, NMDA receptors are significantly involved in working memory. In the present study, we tested whe...

[Survey on the Current Advertising and Sales of Mucuna Pruriens in Consumer-to-consumer Internet Trading in Japan].

Oct 16, 2023

Mucuna Pruriens (MP) is leguminous plant which contains 5% of levodopa in its seeds. It may have a potential to be used as an alternative therapy for Parkinson's disease (PD). Meanwhile, there is a co...

C9orf72 Repeat Expansion Initially Presenting as Late-onset Bipolar Disorder With Psychosis.

Oct 16, 2023

C9orf72 expansion is the most common genetic abnormality in behavioral variant frontotemporal dementia (bvFTD) and amyotrophic lateral sclerosis. Although psychiatric prodromes are common in C9orf72 e...

Lifestyle in bipolar disorder: A cross-sectional study.

Oct 16, 2023

Modifiable lifestyle behaviors are important factors for improving mental health, yet there has been a lack of research studying lifestyle as a multidimensional construct in bipolar disorder (BD). The...

Reinforcement learning and working memory in mood disorders: A computational analysis in a developmental transdiagnostic sample.

Oct 16, 2023

Mood disorders commonly onset during adolescence and young adulthood and are conceptually and empirically related to reinforcement learning abnormalities. However, the nature of abnormalities associat...

Anxiety in Parkinson's Patients: What's Timing Got to Do with It?

Oct 16, 2023

Parkinson's Disease (PD) affects over 10 million people worldwide. Many PD patients experience comorbid anxiety disorders, which have been correlated with reduced quality of life and can manifest at ...

Tobacco smoking related to childhood trauma mediated by cognitive control and impulsiveness in severe mental disorders.

Oct 09, 2023

People with severe mental disorders (SMDs) show an increased prevalence of tobacco smoking compared to the general population. Tobacco smoking and other adult adverse health behaviors have been associ...

G.T. MSRS On-Line Calculator Targeting the Early Diagnosis of Mixed Affective States: the Multicenter Study Project Design on the Approbation and Validity of the Three Language Versions of the Rating Scale.

Oct 09, 2023

Mixed affective states (MS) are often misdiagnosed by the clinicians and lead to the inappropriate treatment strategies contributing to the severe forms, poor outcome with higher rates of comorbid con...

Psychiatric rehabilitation and cognitive deficit for treatment-resistant depression.

Oct 09, 2023

Patients with TRD often experience persistent impairment of affective, psychosocial, and cognitive function, which impedes their recovery. The continuation of pharmacotherapy for patients with TRD rem...

Bidirectional relations between problematic smartphone use and bedtime procrastination among Chinese university students: Self-control as a mediator.

Oct 09, 2023

Based on theoretical and empirical evidence, this study examined the longitudinal relationship between problematic smartphone use and bedtime procrastination and the potential mediating role of self-c...

A randomized controlled trial comparing the efficacy of nifedipine and enalapril in the postpartum period.

Oct 09, 2023

Postpartum hypertension is a common medical complication of pregnancy and is associated with increased healthcare utilization, including unplanned interactions with the medical system and readmission,...

Antipsychotic dose reduction and discontinuation versus maintenance treatment in people with schizophrenia and other recurrent psychotic disorders in England (the RADAR trial): an open, parallel-group, randomised controlled trial.

Oct 02, 2023

Maintenance antipsychotic medication is recommended for people with schizophrenia or recurrent psychosis, but the adverse effects are burdensome, and evidence on long-term outcomes is sparse. We aimed...

Cocaine use disorder effects on blood oxytocin levels and OXTR DNA methylation.

Oct 02, 2023

Substance use disorders have been associated with alterations in the oxytocinergic system, but few studies have investigated both the peptide and epigenetic mechanisms potentially implicated in the re...

Intact Mismatch Negativity Responses in Clinical High-Risk for Psychosis and First-Episode Psychosis: Evidence from Source-Reconstructed Event-Related Fields and Time-Frequency Data.

Oct 02, 2023

To examine whether Mismatch Negativity (MMN) Responses are impaired in participants at clinical high-risk for psychosis (CHR-P) and first episode psychosis (FEP) patients and whether MMN-deficits pred...

Understanding people's experiences of the formal health and social care system for co-occurring heavy alcohol use and depression through the lens of relational autonomy: A qualitative study.

Oct 02, 2023

Heavy alcohol use and depression commonly co-occur. However, health and social care services rarely provide coordinated support for these conditions. Using relational autonomy, which recognizes how so...

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