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Psychiatry General

Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2.

Feb 25, 2021

Arsenic is a metalloid that has been hypothesized to be an enviromental risk factor for Alzheimer's disease (AD), a disease having hyperphosphorylated tau aggregate as a marker. The present study demo...

Abnormal meta-state activation of dynamic brain networks across the Alzheimer spectrum.

Feb 25, 2021

The characterization of the distinct dynamic functional connectivity (dFC) patterns that activate in the brain during rest can help to understand the underlying time-varying network organization. The ...

Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy.

Feb 25, 2021

The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex...

Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease: A Meta-Analysis of Mood Effects.

Feb 25, 2021

This meta-analysis examines mood changes after bilateral subthalamic deep brain stimulation (STN-DBS) in patients with Parkinson's disease (PD). Deep brain stimulation improves motor outcomes in Parki...

Advances in the psychopharmacotherapy of bipolar disorder type I.

Feb 25, 2021

: Research into the pharmacologic management of bipolar type I illness continues to progress.Randomized clinical trials performed with type I bipolar disorder in the years 2015 - August 2020 are revie...

Differences in Demographic and Clinical Characteristics of Patients With Depressive vs. Manic First Episode of Bipolar Disorder.

Feb 25, 2021

Bipolar disorder is a serious mental disease marked by episodes of depression, mania, hypomania, or mixed states. Patients with bipolar disorder may present with different symptoms at first onset. Th...

Evaluation of children's pain expression and behavior using audio visual distraction.

Feb 25, 2021

Dental anxiety distresses children and their families with consequent poor oral health and costly pediatric dental services. Children's behaviors could be modified using a distraction technique for im...

Structural determinants underlying the adduct lifetime in the LOV proteins of Pseudomonas putida.

Feb 25, 2021

The primary photochemistry is similar among the flavin-bound sensory domains of LOV (Light-oxygen-voltage) photoreceptors, where upon blue-light illumination a covalent adduct is formed on the microse...

Utilizing genome wide data to highlight the social behavioral pathways to health: The case of obesity and cardiovascular health among older adults.

Feb 25, 2021

We use genome-wide data from the 1992-2016 Health and Retirement Study (n = 12,090) to characterize obesity among older adults as genetically or socially oriented. To illustrate the significance of ...

Perampanel effectiveness and safety as early add-on treatment for focal-onset seizures: PEREAGAL study.

Feb 25, 2021

Perampanel (PER) is an effective adjunctive therapy for controlling focal-onset seizures (FOS), but few studies have examined its effects as an early add-on for the treatment of FOS in daily clinical ...

Factor structure and psychometric properties of the Connor-Davidson resilience scale (CD-RISC) in individuals with opioid use disorder.

Feb 25, 2021

Resilience is defined as the capacity for an individual to maintain normal functioning and resist the development of psychiatric disorders in response to stress and trauma. Although previous investiga...

Comparison of psychological symptoms and cognitive functions in patients under maintenance treatment with methadone or buprenorphine, current opioid users and healthy subjects.

Feb 25, 2021

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in...

Harmonized Outcome Measures for Use in Depression Patient Registries and Clinical Practice.

Feb 25, 2021

Major depressive disorder is a common mental health condition that affects an estimated 16.2 million adults and 3.1 million adolescents in the United States. Yet, a lack of uniformity remains in measu...

Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review.

Feb 25, 2021

Polygenic risk scores (PRS) are predictors of the genetic susceptibility to diseases, calculated for individuals as weighted counts of thousands of risk variants in which the risk variants and their w...

Estimation of FTD-GRN biomarker changes

Feb 24, 2021

FTD-GRN is a rapid progression disorder. Hence, it is important to model the cascade of biomarkers for understanding the disease’s etiology and for monitoring the mutation carriers. This study aims ...

aLIC (anterior limb of internal capsule) surgery outcomes in OCD vs HCs

Feb 24, 2021

Invasive procedures targeting aLIC can help in treating treatment-refractory OCD. This study understands how the aLIC streamlines are affected in healthy controls and OCD individuals. The study also a...

Understanding the clinical features that help to predict surface-directed autoantibodies

Feb 24, 2021

The study aims to generate a score to assess the clinical features that help identify the surface-directed autoantibodies in subjects with new-onset focal epilepsy. It also aims to understand immunoth...

Systematic Analysis of Current Evidence in Alzheimer Disease

Feb 23, 2021

Evidence for Alzheimer's Disease (AD) is collected using observational prospective studies (OPS). Large community samples and potential causal links are identified. Randomized controlled trials (RCTs)...

Rise in Guillain-Barre Syndrome Cases due to COVID Outbreak

Feb 23, 2021

Guillain-Barré syndrome (GBS) involves immunity system attacks on the nerves. It leads to tingling sensations, nerve weakness, and paralysis. Small series of GBS and single cases were reported during...

Beta-synuclein Marker in Cerebrospinal Fluid of Alzheimer Patients

Feb 23, 2021

Sensory, cognitive, and motor functions are impaired in Alzheimer's disease (AD). This synaptic loss has no association with neurochemical markers in a clinical set-up. Mass spectroscopy confirms beta...

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