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Psychiatry General

Cortical thickness and subcortical volume abnormalities in male crack-cocaine users.

Feb 25, 2021

Crack-cocaine offers a higher risk of abuse than intranasal and intravenous use of cocaine. Yet, current treatments remain disappointing and our understanding of the mechanism of crack-cocaine neuroto...

Evaluation of children's pain expression and behavior using audio visual distraction.

Feb 25, 2021

Dental anxiety distresses children and their families with consequent poor oral health and costly pediatric dental services. Children's behaviors could be modified using a distraction technique for im...

Association between Stroop tasks and heart rate variability features in patients with somatic symptom disorder.

Feb 25, 2021

Patients with somatic symptom disorder (SSD) may have declined parasympathetic activity and selective attention to negative information. We combined Stroop tasks and heart rate variability (HRV) measu...

Ecological momentary assessment as a measurement tool in depression trials.

Feb 25, 2021

We used ecological momentary assessment (EMA) to track symptoms during a clinical trial. Thirty-six participants with major depressive disorder (MDD) and MADRS scores ≥20 were enrolled in a nonrando...

Evaluation of children's pain expression and behavior using audio visual distraction.

Feb 25, 2021

Dental anxiety distresses children and their families with consequent poor oral health and costly pediatric dental services. Children's behaviors could be modified using a distraction technique for im...

Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2.

Feb 25, 2021

Arsenic is a metalloid that has been hypothesized to be an enviromental risk factor for Alzheimer's disease (AD), a disease having hyperphosphorylated tau aggregate as a marker. The present study demo...

Abnormal meta-state activation of dynamic brain networks across the Alzheimer spectrum.

Feb 25, 2021

The characterization of the distinct dynamic functional connectivity (dFC) patterns that activate in the brain during rest can help to understand the underlying time-varying network organization. The ...

Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy.

Feb 25, 2021

The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex...

Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease: A Meta-Analysis of Mood Effects.

Feb 25, 2021

This meta-analysis examines mood changes after bilateral subthalamic deep brain stimulation (STN-DBS) in patients with Parkinson's disease (PD). Deep brain stimulation improves motor outcomes in Parki...

Advances in the psychopharmacotherapy of bipolar disorder type I.

Feb 25, 2021

: Research into the pharmacologic management of bipolar type I illness continues to progress.Randomized clinical trials performed with type I bipolar disorder in the years 2015 - August 2020 are revie...

Differences in Demographic and Clinical Characteristics of Patients With Depressive vs. Manic First Episode of Bipolar Disorder.

Feb 25, 2021

Bipolar disorder is a serious mental disease marked by episodes of depression, mania, hypomania, or mixed states. Patients with bipolar disorder may present with different symptoms at first onset. Th...

Evaluation of children's pain expression and behavior using audio visual distraction.

Feb 25, 2021

Dental anxiety distresses children and their families with consequent poor oral health and costly pediatric dental services. Children's behaviors could be modified using a distraction technique for im...

Structural determinants underlying the adduct lifetime in the LOV proteins of Pseudomonas putida.

Feb 25, 2021

The primary photochemistry is similar among the flavin-bound sensory domains of LOV (Light-oxygen-voltage) photoreceptors, where upon blue-light illumination a covalent adduct is formed on the microse...

Utilizing genome wide data to highlight the social behavioral pathways to health: The case of obesity and cardiovascular health among older adults.

Feb 25, 2021

We use genome-wide data from the 1992-2016 Health and Retirement Study (n = 12,090) to characterize obesity among older adults as genetically or socially oriented. To illustrate the significance of ...

Perampanel effectiveness and safety as early add-on treatment for focal-onset seizures: PEREAGAL study.

Feb 25, 2021

Perampanel (PER) is an effective adjunctive therapy for controlling focal-onset seizures (FOS), but few studies have examined its effects as an early add-on for the treatment of FOS in daily clinical ...

Factor structure and psychometric properties of the Connor-Davidson resilience scale (CD-RISC) in individuals with opioid use disorder.

Feb 25, 2021

Resilience is defined as the capacity for an individual to maintain normal functioning and resist the development of psychiatric disorders in response to stress and trauma. Although previous investiga...

Comparison of psychological symptoms and cognitive functions in patients under maintenance treatment with methadone or buprenorphine, current opioid users and healthy subjects.

Feb 25, 2021

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in...

Harmonized Outcome Measures for Use in Depression Patient Registries and Clinical Practice.

Feb 25, 2021

Major depressive disorder is a common mental health condition that affects an estimated 16.2 million adults and 3.1 million adolescents in the United States. Yet, a lack of uniformity remains in measu...

Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review.

Feb 25, 2021

Polygenic risk scores (PRS) are predictors of the genetic susceptibility to diseases, calculated for individuals as weighted counts of thousands of risk variants in which the risk variants and their w...

Estimation of FTD-GRN biomarker changes

Feb 24, 2021

FTD-GRN is a rapid progression disorder. Hence, it is important to model the cascade of biomarkers for understanding the disease’s etiology and for monitoring the mutation carriers. This study aims ...

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