Jan 20, 2021

Psychiatric comorbidities are prevalent in patients with chronic pancreatitis (CP) and associated with pain and reduced quality of life (QOL), Anna Evans Phillips, MD, MS, explains. “Prior studies h...

Jan 18, 2021

Youth at clinical high risk (CHR) are a unique population enriched for precursors of major psychiatric disorders, especially schizophrenia (SCZ). Recent neuroimaging findings point to abnormalities in...

Jan 18, 2021

Early life trauma (ELT) exposure and posttraumatic stress problem (PTSD) both influence neural structure, which predicts an assortment of emotional health worries all through the life expectancy and m...

Jan 18, 2021

This research conducted an RNA-sequencing profiling study of hiPSC-derived cell lines from schizophrenia (SCZ) subjects, most of which are from a multiplex family, from the population isolate of the C...

Jan 18, 2021

The mesolimbic dopamine system—which originates in the ventral tegmental area and projects to the striatum—has been shown to be involved in the expression of sex-specific behavior and is thought t...

Jan 18, 2021

 The KP modulator AV-101 (4-chlorokynurenine, 4-Cl-KYN), an oral prodrug of 7-chlorokynurenic corrosive (7-Cl-KYNA), a N-methyl-D-aspartate receptor (NMDAR) glycine site opponent, and of 4-chloro-3-h...

Jan 18, 2021

Over the years, various models have been proposed to explain the psychology and biology of drug addiction, built primarily around the habit and compulsion models. Recent research indicates drug addict...

Jan 18, 2021

Lumateperone is a mechanistically novel agent FDA-approved for the treatment of schizophrenia. Efficacy and favorable tolerability of lumateperone were demonstrated in 2 short-term placebo-controlled ...

Jan 18, 2021

Alzheimer's disease (AD) is characterized by accumulation of tau and amyloid-beta in the brain, and recent evidence suggests a correlation between associated protein aggregates and trace elements, suc...

Jan 18, 2021

To evaluate the performance of a Random Forest (RF) classifier on Transcranial Magnetic Stimulation (TMS) measures in patients with Mild Cognitive Impairment (MCI).We applied a RF classifier on TMS me...

Jan 18, 2021

The multi-target-directed ligands have been regarded as the promising multifunctional agents for the treatment of Alzheimer's disease (AD). Based on our previous work, a series of genistein-O-alkylami...

Jan 18, 2021

First, to investigate whether specific manic symptoms in preschool predict manic symptom severity in adolescence. Second, to investigate the interaction between family history (FH) of bipolar disorder...

Jan 18, 2021

Ketamine, a dissociative anaesthetic, has been used in the treatment of major depressive disorder (MDD) as a rapid acting antidepressant drug. Recent studies have shown that ketamine may increase the ...

Jan 18, 2021

The aim of this study is to explore mania as a network of its symptoms, inspired by the network approach to mental disorders.Network structures of both cross-sectional and temporal effects were measur...

Jan 18, 2021

Anhedonia is a core symptom of major depressive disorder (MDD). Two subtypes of anhedonia: anticipatory anhedonia and consummatory anhedonia has been recognized in MDD patients. However, our knowledge...

Jan 18, 2021

Patients with psychotic disorders report to apply more maladaptive and less adaptive emotion-regulation (ER) strategies compared to healthy controls. However, few studies have used experimental design...

Jan 18, 2021

Recent advances in mass spectrometry (MS)-based proteomics have vastly increased the quality and scope of biological information that can be derived from human samples. These advances have rendered cu...

Jan 18, 2021

COMT had been considered a promising candidate gene in pharmacogenetic studies in ADHD; yet the findings from these studies have been inconsistent. Part of these inconsistencies could be related to ep...

Jan 18, 2021

Mental health problems are common amongst adults with an Autism Spectrum Disorder (ASD). Stressful and traumatic life events can trigger or exacerbate symptoms of anxiety, depression and PTSD. In the ...

Jan 18, 2021

Chronic neuropathic pain and prescription opioid abuse represent highly interconnected societal problems. We used a rat model of spared nerve injury (SNI) and an intravenous drug self-administration p...