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Opioids

Rhynchophylline inhibits methamphetamine dependence via modulating the miR-181a-5p/GABRA1 axis.

May 15, 2023

Uncaria rhynchophylla (Miq.) Miq. ex Havil. is a plant species that is routinely devoted in traditional Chinese medicine to treat central nervous system disorders. Rhynchophylline (Rhy), a predominant...

Effect of Pain Education Interventions on Registered Nurses' Pain Management: A Systematic Review and Meta-Analysis.

Apr 10, 2023

This review and meta-analysis aims to reveal how pain education interventions affect registered nurses' pain management.A systematic review and meta-analysis DATA SOURCES: PubMed, Scopus, CINAHL (EBSC...

Pure Laparoscopic Donor Left Hepatectomy Reduces Postoperative Analgesic Use and Pain Scale.

Apr 10, 2023

Many recent reports have described the efficacy and safety of pure laparoscopic donor hepatectomy (PLDH). Here we investigated the extent to which this technique could reduce patients' experienced pai...

Association between pediatric TBI and mental health and substance use disorders: A scoping review.

Mar 06, 2023

The relationship between pediatric Traumatic Brain Injury (TBI) and long-term mental health and substance use disorders is not well known, resulting in inadequate prevention and management strategies....

Mood Variability, Craving, and Substance Use Disorders: From Intrinsic Brain Network Connectivity to Daily Life Experience.

Feb 13, 2023

Substance use disorders (SUDs) are major contributors to morbidity and mortality rates worldwide, and this global burden is attributable in large part to the chronic nature of these conditions. Increa...

Transcriptomics and metabolomics together reveal the underlying mechanism of heroin hepatotoxicity.

Dec 12, 2022

Researches on heroin are more about addiction and some infectious diseases it causes, but liver fibrosis caused by heroin abuse and the mechanism of heroin hepatotoxicity in addicts are ignored. To ex...

Development, evaluation and adaptation of a critical realism informed theory of procedural pain management in preterm infants: The PAIN-Neo theory.

Dec 05, 2022

To present the development, evaluation and adaptation of the PAIN-Neo theory.Theory development.A review of literature was conduct from 1980 to 2021.Using a critical realism paradigm, this paper prese...

National Trends and Prescription Patterns in Opiate Analgesia

Jul 08, 2022

For a study, researchers sought to examine the National Hospital Ambulatory Medical Care Survey (NHAMCS) database for regional and temporal patterns, as well as characteristics linked with the chance ...

Healthcare Exposure Ups Opioid Misuse Risk in Young Adults

Jun 24, 2022

Young adults exposed to inpatient hospitalizations, EDs, or mental health facilities had an increased risk for opioid misuse later in adulthood. Opioid misuse increased dramatically throughout ...

From the Physician Editor-in-Chief - Chronic Pain: We Need to Ask “Why?”

May 31, 2022

According to the CDC, there are approximately 50 million people in the US living in chronic pain. We all know about the opioid crisis, and this knowledge has done nothing to help alleviate pain many a...

A descriptive survey of substance use treatment facilities in Uasin Gishu County Kenya.

May 16, 2022

Substance use disorders are a major problem in Uasin Gishu County, Kenya. The objective of this study was to describe the existing resources within substance use treatment facilities in the County, wi...

Analgesic effect of auricular point acupressure for acute pain in patients with dementia: study protocol for a randomized controlled trial.

May 16, 2022

Common and frequent as acute pain is, it is often underestimated and undertreated in older people with dementia in nursing homes and inadequate pain management remains an issue.The study is designed t...

A qualitative exploration of daily path and daily routine among people in Ukraine who inject drugs to understand associated harms.

May 09, 2022

Patterns of movement, heterogeneity of context, and individual space-time patterns affect health, and individuals' movement throughout the landscape is shaped by addiction, meeting basic needs, and ma...

Impacts of a Medicaid "lock-in" program on opioid use disorder treatment and services and naloxone dispensing.

Mar 14, 2022

"Lock-in" programs are used by health insurers to reduce the risk of adverse outcomes that can result from overutilization of opioids and other controlled substances. We estimated the association betw...

"It's not just the hit itself": the social practice of injecting drug use among gay and bisexual men in Australia.

Mar 07, 2022

Injecting drug use is purportedly more common among gay and bisexual men (GBM) than the general Australian population. Approaches designed to support the wellbeing of people who inject drugs may not b...

TMS for the functional evaluation of cannabis effects and for treatment of cannabis addiction: A review.

Feb 28, 2022

The knowledge about the effects of cannabis on human cortical brain processes is increasing. In this regard, transcranial magnetic stimulation (TMS) enables the evaluation of central nervous system fu...

Parent-adolescent relationships, peer relationships, and adolescent mobile phone addiction: The mediating role of psychological needs satisfaction.

Feb 14, 2022

Prior studies have shown that parent-adolescent relationships and peer relationships may be important factors associated with adolescent mobile phone addiction (MPA). The present study aims to further...

Comparison of Health Care Expenditures Among U.S. Older Adults With Pain Who Reported Frequent Exercise Versus Nonfrequent Exercise.

Dec 27, 2021

This cross-sectional study included a nationally representative sample of U.S. adults aged ≥50 years with self-reported pain in the past 4 weeks from the 2018 Medical Expenditure Panel Survey. Adjus...

Are short AUDIT screeners effective in identifying unhealthy drinking of varying severity? A prison population study.

Nov 22, 2021

Whether brief versions of the Alcohol Use Disorder Identification Test (AUDIT) can be used as graded severity measures is largely unknown. We examined the performance of eight such brief screeners in ...

Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial.

Oct 18, 2021

Extensive evidence suggests that alpha-lipoic acid (ALA) is effective in diabetic neuropathy pain management. However, little is known on its safety and efficacy in reducing idiopathic pain in normogl...

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