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Pain Management

Pressure pain thresholds in children before and after surgery: a prospective study.

Feb 04, 2020

Background and aims This prospective study aimed to assess pressure pain thresholds (PPTs) by pressure algometry and the correlation to postoperative pain in children undergoing orthopaedic surgery. W...

CYP450-Mediated Metabolism of Mitragynine and Investigation of Metabolites in Human Urine.

Feb 04, 2020

Mitragyna speciosa (Kratom) has emerged as a recreational drug and a substance of medicinal intrigue. Although the drug was initially used recreationally for its sedating and euphoric effects, more re...

Proactive Pain Management May Cut Postop Opioid Prescriptions

Feb 03, 2020

MONDAY, Feb. 3, 2020 (HealthDay News) -- An enhanced recovery after surgery program complemented by a preemptive pain management program is associated with a decrease in opioid prescriptions at discha...

GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents.

Jan 31, 2020

Treating neuropathic pain is challenging and novel non-opioid based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence and in situ hybridization, we found th...

Opioid Prescribing Behaviors - Prescription Behavior Surveillance System, 11 States, 2010-2016.

Jan 31, 2020

In 2017, a total of 70,237 persons in the United States died from a drug overdose, and 67.8% of these deaths involved an opioid. Historically, the opioid overdose epidemic in the United States has bee...

Achieving Opioid-Free Major Colorectal Surgery: Is It Possible?

Jan 31, 2020

Opioid analgesia remains the mainstay of postoperative pain management strategies despite being associated with many adverse effects. A specific opioid-free protocol was designed to limit opioid usage...

An 8-Year Retrospective Study on Suicides in Washington, DC.

Jan 31, 2020

The suicide rate in the United States has been increasing steadily over the previous 10 years. In DC, these results are not mirrored. The suicide rate has a tendency to be lower than the rest of the c...

Therapeutic Drug Monitoring in Buprenorphine/Naloxone Treatment for Opioid Use Disorder: Clinical Feasibility and Optimizing Assay Precision.

Jan 31, 2020

Compliance with sublingual buprenorphine/naloxone (SL-BUP/NX) is associated with higher abstinence from illicit opioid use. Therapeutic drug monitoring (TDM) has been recommended for adherence monitor...

Prognostic factors for improved physical and emotional functioning one year after interdisciplinary rehabilitation in patients with chronic pain: Results from a national quality registry in Sweden.

Jan 30, 2020

To investigate prognostic factors for physical and emotional functioning following interdisciplinary multimodal pain rehabilitation, by targeting patients' baseline characteristics and health measures...

Rapid Point of Care Test for Detecting Urogenital Chlamydia Trachomatis Infection

Jan 30, 2020

Chlamydia trachomatis (C trachomatis) is one of the most frequent sexually transmitted infections and a source of deleterious effects on the reproductive health of men and women. Because this infectio...

Skin Infections and Outpatient Burn Management: Outpatient Burn Management.

Jan 30, 2020

Burns, whether caused by thermal, chemical, or electrical exposure, are common and often preventable. Burn injuries are most common in children. All patients with burns should undergo primary and seco...

Evaluating lactate prognostic value in children suspected of acetaminophen-induced liver failure in Liberia.

Jan 30, 2020

The prognostic significance of hyperlactatemia in young children with liver injury suspected to be attributed to repeated supratherapeutic doses of acetaminophen remain understudied.We conducted a ret...

A Narrative Pharmacological Review of Buprenorphine: A Unique Opioid for the Treatment of Chronic Pain.

Jan 30, 2020

Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid receptor agonists. The structu...

Anti-inflammatory and metabolic reprogramming effects of MENK produce antitumor response in CT26 tumor-bearing mice.

Jan 30, 2020

Methionine enkephalin (MENK), an endogenous opioid peptide, has a role in nervous system, immune system, and anticancer therapy. Inflammation, metabolism and cancer are closely intertwined with each o...

The identification of risk factors contributing to accidental opioid poisonings in companion dogs using data from a North American poison control center (2006-2014).

Jan 30, 2020

In the last decade, there has been a marked increase in opioid-related human deaths in the U.S. However, the effects of the growth in opioid use on vulnerable populations, such as pet dogs, are largel...

Association between Adult Attention Deficit/Hyperactivity Disorder and Intravenous Misuse of Opioid and Benzodiazepine in Patients under Opioid Maintenance Treatment: A Cross-Sectional Multicentre Study.

Jan 30, 2020

Intravenous misuse and attention-deficit/hyperactivity disorder (ADHD) are common in patients under opioid maintenance treatment (OMT), who often misuse benzodiazepine (BZD).To explore the rate of adu...

Change Healthcare Study Reveals Impact of Payment Audits on Payer-Provider Relationships

Jan 27, 2020

Media contact: Change Healthcare Kerry Kelly External Communications 339-236-2756 kerry.kelly@changehealthcare.com   Study finds audits process poses significant costs and administrati...

Effects of oxycodone and diazepam alone and in combination on operant nociception.

Jan 24, 2020

Developing effective analgesics with fewer unwanted side effects is a pressing concern. Due to a lack of effective nonopioid options currently available, an alternative approach termed opioid-sparing ...

Evaluating preterm care across Europe using the eNewborn European Network database.

Jan 24, 2020

The inefficiency of recording data repeatedly limits the number of studies conducted. Here we illustrate the wider use of data captured as part of the European eNewborn benchmarking programme.We extra...

Use and Misuse of Opioids After Endocrine Surgery Operations.

Jan 24, 2020

To examine the rate of new and persistent opioid use after endocrine surgery operations SUMMARY OF BACKGROUND DATA:: A global epidemic of opioid misuse and abuse has been evolving over the past 2 deca...

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