Osteoporosis
Apr 12, 2020
Osteoporosis and its related fractures are major public health concerns. Physical activity (PA) is crucial for bone density preservation and fractures prevention. Yet, gaps in understanding exist rega...
Apr 12, 2020
To evaluate upadacitinib efficacy and safety dose response in Japanese patients with active RA and an inadequate response to conventional synthetic DMARDs (csDMARDs).This was a multicentre, phase IIb/...
Apr 12, 2020
Our objective was to characterize Canadian workforce attributes of extended role practitioners (ERPs) in arthritis care.We used an exploratory, mixed-methods study that was based on the Canadian Rheum...
Apr 12, 2020
Sodium alendronate is a nitrogen-containing bisphosphonate, widely used for osteoporosis treatment. However, due to its several oral administration drawbacks, the transdermal route represents an inter...
Apr 08, 2020
Data indicate that the declining trend of hip fracture among Americans plateaued in 2012 before increasing through present day. “Since hip fractures are the most common result of osteoporosis, this ...
Apr 03, 2020
Fructus Psoraleae (FP), one of the significant traditional Chinese medicines, has been reported to cause hepatotoxicity. However, the mechanism remains undetermined and the reported research is limite...
Apr 03, 2020
Low bone mineral density (BMD) is associated with increased risk of fractures and mortality. We investigated if rate of BMD loss in the distal forearm over seven years predicted mortality.1725 postmen...
Apr 03, 2020
Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis dominated systemic disease with unknown etiology. The purpose of this study was to determine the relationship between IL1B polymorphisms ...
Mar 24, 2020
Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition ...
Mar 24, 2020
T-cell receptor (TCR) signaling is initiated by recruiting ZAP-70 to the cytosolic part of TCR. ZAP-70, a non-receptor tyrosine kinase, is composed of an N-terminal tandem SH2 (tSH2) domain connected ...
Mar 24, 2020
Physical inactivity is prevalent in rheumatoid arthritis (RA) patients, increasing the risk of poor physical health and compromised well-being. Interventions are therefore required to support physical...
Mar 24, 2020
With significant improvements in the treatment of HIV in recent years, life expectancy in patients living with HIV (PLHIV) has increased dramatically and is now near to that of the general populatio...
Mar 19, 2020
Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association...
Mar 19, 2020
Intrinsic complement C3 activity is integral to human T helper type 1 (Th1) and cytotoxic T cell responses. Increased or decreased intracellular C3 results in autoimmunity and infections, respectivel...
Mar 19, 2020
Arp is an immunogenic protein of the Lyme disease spirochete Borrelia burgdorferi and contributes to joint inflammation during infection. Despite Arp eliciting a strong humoral response, antibodies fa...
Mar 19, 2020
Securidaca inappendiculata is a xanthone rich medicinal plant that has been used in the treatment of inflammation and autoimmune diseases like rheumatoid arthritis (RA) for centuries; however, the mat...
Mar 10, 2020
Retrospective observational cohort study.We used observational measures and retrospective chart reviews to compare elderly patients with osteoporosis who underwent multi-level anterior lumbar interbod...
Mar 10, 2020
Immune checkpoint inhibitors (ICIs) represent an important advance in the treatment of melanoma. ICIs may induce autoimmune phenomena caused by concurrent activation of the immune system against norma...
Mar 10, 2020
Patients with posterior shoulder instability may have bone and cartilage lesions (BCLs) in addition to capsulolabral injuries, although the risk factors for these intra-articular lesions are unclear.W...
Mar 09, 2020
Data indicate that nearly 400,000 lumbar punctures (LPs) are performed annually for either diagnostic workup or therapeutic relief in the United States. Regular referral to radiology for assistance ...