Interleukin 15 a Potential Treatment Target for Severe Asthma
Interleukin 15 expression in asthmatic airways negatively correlated with lung function, a finding that improves understanding of asthma heterogeneity.
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Severe Eosinophilic Asthma
Monoclonal Antibodies Beneficial in Severe Asthma Exacerbations
Researchers reported significant clinical improvements following the use of monoclonal antibodies in patients with severe asthma exacerbations.
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How Do Comorbidities Impact Severe Asthma Treatment?
Regardless of the presence of nasal polyps and aeroallergen sensitivity, patients with severe eosinophilic asthma can benefit from treatment with mepolizumab.
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Why Severe Asthma Treatment Requires Better Predictive Tools
Survey results show that clinicians largely disagree about choices for severe asthma treatment, due primarily to a lack of formal guidelines.
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Novel Ventilation Index for Severe Asthma Shows Prognostic Value
A new ventilation index for severe asthma derived from computed cardiopulmonography data was a sensitive marker for inflammation in type-2 high asthma.
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Severe Asthma Significantly Impairs Patients’ Ability to Work
Severe asthma impacts patients’ ability to work in multiple ways due to the psychological burden of the disease and the adaptations needed to remain employed.
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Model Predicts Severe Asthma Based on Immune-Related Hub Genes
Researchers have identified immune response-related hub genes that could act as diagnostic markers and potentially therapeutic targets for severe asthma.
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Severe Asthma Trajectory Prior to Treatment Influences Outcomes
Pre-treatment disease trajectories in severe asthma impact treatment-related outcomes, according to a study by Johannes Martin Schmid, PhD, and colleagues.
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How Prevalent is ABPA in Patients With Asthma or Cystic Fibrosis?
A study of US insurance data determined ABPA prevalence among patients with asthma and those with CF and offered insights into testing and treatment patterns.
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Chronic Cough Worsens Control & QOL in Severe Asthma
Chronic cough in severe asthma was associated with worsened asthma control and patient QOL, according to a recent study published in JACI: In Practice.
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Patients With Severe Asthma Benefit From Simple Psychoeducational Intervention
A psychoeducational intervention for extrapulmonary manifestations of severe asthma was found feasible and rated as beneficial by patients.
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Bronchial Biopsy Bests T2 Score in Predicting Biologic Response
Bronchial biopsy appears more precise than T2 score in predicting response to biological therapy for severe uncontrolled asthma.
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Sputum Total IgE an Indicator of Uncontrolled Asthma
Study results indicate that sputum total IgE can be used as an indicator of uncontrolled asthma.
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Is Clinical Remission a Feasible Goal in Long-Term Treatment for Severe Asthma?
Researchers gathered real-world data on biologic therapy to determine the feasibility of targeting clinical remission when treating patients with severe asthma.
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Predicting Early Versus Late Response to Treatment in SEA
Early improvement was linked to lower baseline FEV1 and higher eosinophils in severe eosinophilic asthma, while late improvement was linked to high ACT scores.
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Does Emphysema Impact Treatment Response in Severe Asthma?
Emphysema did not significantly affect the response to systemic therapy in patients with severe asthma, according to a recent retrospective study.
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