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Surgery General

Predictors of long-term opioid effectiveness in chronic non-cancer pain patients attending multidisciplinary pain treatment clinics: A Quebec Pain Registry study.

Mar 19, 2020

This study aimed at identifying characteristics of individuals who are most likely to benefit from long-term opioid therapy in terms of reduction in pain severity and improved mental health-related qu...

Enduring consequences of perinatal fentanyl exposure in mice.

Mar 19, 2020

Opioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome (NOWS) and lifelong neurobe...

Appropriate referral and selection of patients with chronic pain for Spinal Cord Stimulation: European consensus recommendations and e-health tool.

Mar 19, 2020

Spinal cord stimulation (SCS) is an established treatment for chronic neuropathic, neuropathic-like and ischaemic pain. However, the heterogeneity of patients in daily clinical practice makes it often...

Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment.

Mar 19, 2020

Platelet engraftment following cord blood (CB) transplantation remains a significant hurdle to this day. The uncontrolled growth of ice, a process referred to as ice recrystallization, is one of sever...

Investigating association of perineural invasion on prostate biopsy with Gleason score upgrading at prostatectomy: A multi-institutional analysis.

Mar 19, 2020

The significance of perineural invasion (PNI) in prostate cancer (PC) is unclear. A recent report of patients with pT2N0R0 PC found that PNI at prostatectomy was independently associated with higher G...

FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.

Mar 19, 2020

Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we s...

Lymphovascular Infiltration, Not Depth of Invasion, is the Critical Risk Factor of Metastases in Early Colorectal Cancer: Retrospective Population-based Cohort Study on Prospectively Collected Data, Including Validation.

Mar 19, 2020

To identify clinical and histopathological risk factors of LNM in T1 CRC.The requisite of additional surgery after locally resected T1 CRC is dependent on the risk of LNM. Depth of submucosal invasion...

Developments in consolidation and maintenance strategies in post-remission multiple myeloma.

Mar 13, 2020

: Multiple Myeloma (MM) is a very heterogeneous clonal plasma cell hematological malignancy for which new therapies and transplantation effectively improve Progression-free survival (PFS) and overall ...

Utilization of Direct Acting Oral Anticoagulation in Solid Organ Transplant Patients: A National Survey of Institutional Practices.

Mar 13, 2020

The safety and efficacy of direct acting oral anticoagulants (DOACs) and reversal strategies are not well established in the solid organ transplant population. This was a survey of pharmacists to asse...

Pharmacogenetic-Whole blood and intracellular pharmacokinetic-Pharmacodynamic (PG-PK2-PD) relationship of tacrolimus in liver transplant recipients.

Mar 13, 2020

Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating the interplay between pharmacogenetic determinants of TAC whole blood and int...

Delayed versus initial cytomegalovirus prophylaxis after kidney transplantation.

Mar 13, 2020

It is recommended to start cytomegalovirus (CMV) prophylaxis within ten days of solid organ transplant, if indicated. Our center underwent a cost-savings initiative to delay CMV prophylaxis initiation...

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.

Mar 13, 2020

Acute kidney injury (AKI) is a major comorbidity in hospitalised patients. Patients with severe AKI require continuous renal replacement therapy (CRRT) when they are haemodynamically unstable. CRRT is...

Homozygous familial hypercholesterolemia with severe involvement of the aortic valve-A sibling-controlled case study on the efficacy of lipoprotein apheresis.

Mar 13, 2020

Homozygous familial hypercholesterolemia (hoFH) can cause severe atherosclerotic cardiovascular disease (ASCVD) in early infancy. Diagnosis and initiation of effective lipid-lowering therapy (LLT) are...

Institutional experience of healthy pediatric patients presenting with atrial fibrillation who had an electrophysiology study.

Mar 13, 2020

Atrial fibrillation (AF) is a very common tachyarrhythmia with increasing prevalence with age, but uncommon in the pediatric population. Understanding that AF increases comorbidities make the need for...

Refractive twisted microaxicons.

Mar 13, 2020

Complex-shaped light fields with specially designed intensity, phase, and polarization distributions are highly demanded for various applications including optical tweezers, laser material processing,...

Three-dimensional reconstruction of the suborbicularis oculi fat and the infraorbital soft tissue.

Mar 13, 2020

The aim of this study was to reveal the histomorphological connections among the suborbicularis oculi fat (SOOF), the orbicularis oculi muscle (OOM), the superficial musculoaponeurotic system (SMAS), ...

Patient-related reasons for late surgery cancellations in a plastic and reconstructive surgery department.

Mar 13, 2020

Late cancellations of scheduled operations cause direct and indirect costs for a hospital and economic and emotional stress for the patient. Previously, late cancellation rates for scheduled operation...

A systematic review of the effectiveness and complications of fat grafting in the facial region.

Mar 13, 2020

The objective of this study was to evaluate the safety and efficacy of fat grafting to the facial region for the reconstruction and aesthetic enhancement of facial contour.A systematic literature revi...

[Method for obtaining blood culture while diagnosing bloodstream infection.]

Mar 13, 2020

Diagnosing of bloodstream infection (BSI) in outpatients is essential. A large blood volume is required to obtain blood culture (CLSI): 2 sets, 40ml of blood for diagnosing in 95% cases of bacteremia....

Development and growth of auricular cartilage and muscles: A study using human fetuses.

Mar 13, 2020

The auricle is a key target in pediatric plastic surgery and is considered to develop from a ring- or funnel-like arrangement of six hillocks in the embryo. However, there has been no report showing t...

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