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Surgery General

Lymphovascular Infiltration, Not Depth of Invasion, is the Critical Risk Factor of Metastases in Early Colorectal Cancer: Retrospective Population-based Cohort Study on Prospectively Collected Data, Including Validation.

Mar 19, 2020

To identify clinical and histopathological risk factors of LNM in T1 CRC.The requisite of additional surgery after locally resected T1 CRC is dependent on the risk of LNM. Depth of submucosal invasion...

Developments in consolidation and maintenance strategies in post-remission multiple myeloma.

Mar 13, 2020

: Multiple Myeloma (MM) is a very heterogeneous clonal plasma cell hematological malignancy for which new therapies and transplantation effectively improve Progression-free survival (PFS) and overall ...

Utilization of Direct Acting Oral Anticoagulation in Solid Organ Transplant Patients: A National Survey of Institutional Practices.

Mar 13, 2020

The safety and efficacy of direct acting oral anticoagulants (DOACs) and reversal strategies are not well established in the solid organ transplant population. This was a survey of pharmacists to asse...

Pharmacogenetic-Whole blood and intracellular pharmacokinetic-Pharmacodynamic (PG-PK2-PD) relationship of tacrolimus in liver transplant recipients.

Mar 13, 2020

Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating the interplay between pharmacogenetic determinants of TAC whole blood and int...

Delayed versus initial cytomegalovirus prophylaxis after kidney transplantation.

Mar 13, 2020

It is recommended to start cytomegalovirus (CMV) prophylaxis within ten days of solid organ transplant, if indicated. Our center underwent a cost-savings initiative to delay CMV prophylaxis initiation...

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.

Mar 13, 2020

Acute kidney injury (AKI) is a major comorbidity in hospitalised patients. Patients with severe AKI require continuous renal replacement therapy (CRRT) when they are haemodynamically unstable. CRRT is...

Homozygous familial hypercholesterolemia with severe involvement of the aortic valve-A sibling-controlled case study on the efficacy of lipoprotein apheresis.

Mar 13, 2020

Homozygous familial hypercholesterolemia (hoFH) can cause severe atherosclerotic cardiovascular disease (ASCVD) in early infancy. Diagnosis and initiation of effective lipid-lowering therapy (LLT) are...

Institutional experience of healthy pediatric patients presenting with atrial fibrillation who had an electrophysiology study.

Mar 13, 2020

Atrial fibrillation (AF) is a very common tachyarrhythmia with increasing prevalence with age, but uncommon in the pediatric population. Understanding that AF increases comorbidities make the need for...

Refractive twisted microaxicons.

Mar 13, 2020

Complex-shaped light fields with specially designed intensity, phase, and polarization distributions are highly demanded for various applications including optical tweezers, laser material processing,...

Three-dimensional reconstruction of the suborbicularis oculi fat and the infraorbital soft tissue.

Mar 13, 2020

The aim of this study was to reveal the histomorphological connections among the suborbicularis oculi fat (SOOF), the orbicularis oculi muscle (OOM), the superficial musculoaponeurotic system (SMAS), ...

Patient-related reasons for late surgery cancellations in a plastic and reconstructive surgery department.

Mar 13, 2020

Late cancellations of scheduled operations cause direct and indirect costs for a hospital and economic and emotional stress for the patient. Previously, late cancellation rates for scheduled operation...

A systematic review of the effectiveness and complications of fat grafting in the facial region.

Mar 13, 2020

The objective of this study was to evaluate the safety and efficacy of fat grafting to the facial region for the reconstruction and aesthetic enhancement of facial contour.A systematic literature revi...

[Method for obtaining blood culture while diagnosing bloodstream infection.]

Mar 13, 2020

Diagnosing of bloodstream infection (BSI) in outpatients is essential. A large blood volume is required to obtain blood culture (CLSI): 2 sets, 40ml of blood for diagnosing in 95% cases of bacteremia....

Development and growth of auricular cartilage and muscles: A study using human fetuses.

Mar 13, 2020

The auricle is a key target in pediatric plastic surgery and is considered to develop from a ring- or funnel-like arrangement of six hillocks in the embryo. However, there has been no report showing t...

Honeycomb blocks composed of carbonate apatite, β-tricalcium phosphate, and hydroxyapatite for bone regeneration: effects of composition on biological responses.

Mar 13, 2020

Synthetic scaffolds exhibiting bone repair ability equal to that of autogenous bone are required in the fields of orthopedics and dentistry. A suitable synthetic bone graft substitute should induce os...

Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Polyetheretherketone Implants.

Mar 13, 2020

Polyetheretherketone (PEEK) is a biocompatible polymer, but the lack of angiogenesis makes the long-term osteogenic fixation of PEEK implants challenging, which has hampered their wider application in...

Are plain radiographs reliable in Lichtman classification?

Mar 13, 2020

This study aims to investigate the reliability of the Lichtman classification among residents, orthopedic surgeons, and hand surgeons.This study was carried out with 30 male observers (mean age 37.8 y...

Comparison of Turkish and international trends in carpal tunnel surgery.

Mar 13, 2020

This study aims to analyze the nationwide trends in carpal tunnel surgery by surgeons practicing in Turkey according to experience in years, training received (plastic surgery or orthopedics), and wor...

A mechanistic study and review of volatile products from peroxidation of unsaturated fatty acids: an aid to understanding the origins of volatile organic compounds from the human body.

Mar 13, 2020

The assessment of volatile compounds (VOCs) for disease diagnosis is a growing area of research. There is a need to provide hard evidence i.e. biochemical routes, to justify putative VOC biomarkers, a...

Inhibition of Interleukin-6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice.

Mar 13, 2020

The role of IL-6 signalling in hypertensive heart disease and its sequelae is controversial. Our group demonstrated that Bazedoxifene suppressed IL-6/gp130 signalling in cancer cells but its effect on...

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