Mar 10, 2020

Establish whether POCD is associated with new disability after surgery, which would inform whether POCD impacts patient-centered outcomes.POCD is a decline in neuropsychiatric tests scores from presur...

Mar 10, 2020

To examine the association between Textbook Outcome (TO)-a new composite quality measurement-and long-term survival in gastric cancer surgery.Single-quality indicators do not sufficiently reflect the ...

Mar 10, 2020

To investigate the long-term effect of flexible duty-hour policies on resident outcomes BACKGROUND:: The Flexibility in Duty Hour Requirements for Surgical Trainees trial showed no significant differe...

Mar 10, 2020

Identification of gene mutations that are indicative of epithelial-mesenchymal transition and a noninflammatory immune phenotype may be important for predicting response to immune checkpoint inhibitor...

Mar 10, 2020

In KEYNOTE-189, first-line pembrolizumab plus pemetrexed-platinum significantly improved overall survival (OS) and progression-free survival (PFS) compared with placebo plus pemetrexed-platinum in pat...

Mar 10, 2020

Interstitial lung disease (ILD) induced by anti-programmed-cell death-1 (PD-1) and anti-PD-ligand 1 (PD-L1) is potentially life-threatening and is a common reason of the discontinuation of therapy. In...

Mar 10, 2020

The aims of this study were to investigate the expression of prolyl 4-hydroxylase subunit alpha-1 (P4HA1) and its relationship with clinicopathological features in lung cancer (LC), breast cancer (BC)...

Mar 10, 2020

The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exo...

Mar 10, 2020

Retrospective database study.We sought to investigate trends and risk factors for new onset anxiety and/or depression within six months after elective spine surgery.Surgery represents a stressful expe...

Mar 10, 2020

To evaluate the SUMMIT-07 trial opioid withdrawal results of NKTR-181 (oxycodegol), a new molecular entity mu-opioid receptor agonist.Phase 3, enriched-enrollment, double-blind, randomized-withdrawal ...

Mar 10, 2020

Vertebroplasty is a percutaneous minimally invasive procedure indicated for vertebral collapse pain treatment. Among the known complications of the procedure is the augmented risk of new vertebral fra...

Mar 10, 2020

While primary care clinicians are being trained to use buprenorphine for the treatment of Opioid Use Disorder (OUD) in order to increase access to addiction treatment, it is not known what impact suc...

Mar 10, 2020

Understanding hepatitis C virus (HCV) transmission among people who inject drugs (PWID) is essential for HCV elimination. We aimed to differentiate reinfections from treatment failures and to identify...

Mar 10, 2020

Your health insurance has limited surgical coverage, but you'd be amazed at what I can do with nail clippers and duct tape. ...

Mar 09, 2020

Data indicate that nearly 400,000 lumbar punctures (LPs) are performed annually for either diagnostic workup or therapeutic relief in the United States. Regular referral to radiology for assistance ...

Mar 05, 2020

Crossmatching of prospective renal transplant donors against recipients is a mandatory component of the transplant workup, being performed for over 40 years now. Allografting patients with human leuko...

Mar 05, 2020

Direct-acting antivirals have revolutionized hepatitis C treatment, also for patients with chronic kidney disease (CKD), but some controversy exists regarding the use of sofosbuvir (SOF) in patients w...

Mar 05, 2020

Early assessment of renal allograft function post-transplantation is crucial to minimize and control allograft rejection. Biopsy-the gold standard-is used only as a last resort due to its invasiveness...

Mar 05, 2020

Mechanisms of scar-related ventricular tachycardia (VT) are largely based on computational and animal models that portray a 2-dimensional view.The authors sought to delineate the human VT circuit with...

Mar 05, 2020

A clear understanding of the normal anatomy of the glanular urethra is essential for anatomical reconstruction of the male urethra. In hypospadias surgery, tubularization of the neourethra over a cath...