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Surgery General

Regional Wait Times for Patients With Nonmelanoma Skin Cancer in Southwestern Ontario.

Mar 02, 2020

Nonmelanoma skin cancer (NMSC) affects many Canadians. Although morbidity and mortality are rare, the burden to patients and the health-care system is significant. This study aims to evaluate current ...

High-Risk Plastic Surgery: An Analysis of 108,303 Cases From the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP).

Mar 02, 2020

There is a lack of large-scale data that examine complications in plastic surgery. A description of baseline rates and patient outcomes allows better understanding of ways to improve patient care and ...

Three-dimensional surface imaging in breast cancer: a new tool for clinical studies?

Mar 02, 2020

Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncol...

The applications of machine learning in plastic and reconstructive surgery: protocol of a systematic review.

Mar 02, 2020

Machine learning, a subset of artificial intelligence, is a set of models and methods that can automatically detect patterns in vast amounts of data, extract information and use it to perform various ...

Structure and ingredient-based biomimetic scaffolds combining with autologous bone marrow-derived mesenchymal stem cell sheets for bone-tendon healing.

Mar 02, 2020

Tendon attaches to bone across a robust fibrocartilaginous tissue termed the bone-tendon interface (BTI), commonly injured in the field of sports medicine and orthopedics with poor prognosis. So far, ...

Biology-inspired microphysiological systems to advance medicines for patient benefit and animal welfare.

Mar 02, 2020

The first microfluidic microphysiological systems (MPS) entered the academic scene more than 15 years ago and were considered an enabling technology to human (patho)biology in vitro and, therefore, pr...

Patient knowledge, experiences and preferences regarding retinoblastoma and research: A qualitative study.

Mar 02, 2020

We launched a patient engagement strategy to facilitate research involvement of the retinoblastoma (childhood eye cancer) community in Canada. To inform our strategy, we aimed to uncover the experienc...

Identifying the core attributes of pediatric communication techniques to be taught to anesthetic trainees.

Mar 02, 2020

Anesthetic induction and other procedures performed by anesthetists are potentially stressful for children. Pediatric anesthetists use communication to rapidly establish rapport and engagement with ch...

Effects of inhalation of sevoflurane at different concentrations on TRPV1 in airways of rats at different developmental stages.

Mar 02, 2020

Aim Determine changes in the expressions of the ion channel-TRPV1-and neuropeptides-NKA, NKB, calcitonin gene-related peptide (CGRP), and SP-in 14-, 21-, and 42-day-old rats after inhaling 1.5% and 2....

Impact of intraoperative noise measurement on the surgeon stress and patient outcomes. A prospective, controlled, single-center clinical trial with 664 patients.

Mar 02, 2020

The impact of sound-activated noise meters to decrease the noise level in the operating room is not clear. The aim of this study was to determine whether a sound-activated, visual noise meter would de...

Kidney Disease-Specific Scores and Health Utility of Continuous Ambulatory Peritoneal Dialysis Patients, Automated Peritoneal Dialysis Patients, and Caregivers.

Mar 02, 2020

This study aimed to compare the EuroQol 5-dimension 5-level questionnaire (EQ-5D-5L), the visual analogue scale (VAS), and the Kidney Disease Quality of Life 36-Item Short-Form Survey (KDQOL-36) score...

Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression.

Mar 02, 2020

Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opioid-induced hyperalgesia, both limiting the analgesic use of morphine. We e...

Opioid prescriptions in emergency departments: Findings from the 2016 National Hospital Ambulatory Medical Care Survey.

Mar 02, 2020

In the past decade, there has been a rising trend in the emergency department (ED) visits in the US and these visits carry a significant burden of prescription opioids. This study utilized the latest ...

Comprehensive Analysis of the Effects of Ketorolac Administration After Pancreaticoduodenectomy.

Mar 02, 2020

Outcome improvement is a major goal of pancreatic surgery. Such efforts include decreasing perioperative narcotic use to optimize care and reduce potential contributions to the opioid crisis. Ketorola...

Detection of non-reciprocal/reciprocal ALK translocation as poor predictive marker in first-line crizotinib-treated ALK-rearranged non-small cell lung cancer patients.

Mar 02, 2020

During non-reciprocal/reciprocal translocation process, 5'-ALK sometimes get retained in the genome and are detectable by next-generation sequencing (NGS); however, no report have investigated its cli...

The significance of epidermal growth factor receptor uncommon mutations in non-small cell lung cancer: A systematic review and critical appraisal.

Mar 02, 2020

Uncommon epidermal growth factor receptor (EGFR) mutations collectively account for 10% of EGFR mutations, harboring heterogeneous molecular alterations within exons 18-21 with clinically variable res...

Phase distribution of polycyclic aromatic hydrocarbons and their oxygenated and nitrated derivatives in the ambient air of a Brazilian urban area.

Mar 02, 2020

Air quality in large cities has worsened in recent years as a consequence people's health is directly affected. Among the toxic compounds released to environmental air are polycyclic aromatic hydrocar...

Insight into the binding behavior of ceritinib on human α-1 acid glycoprotein: Multi-spectroscopic and molecular modeling approaches.

Mar 02, 2020

Ceritinib is a second-generation anaplastic lymphoma kinase (ALK) inhibitor for mainly treating non-small cell lung cancer (NSCLC). This investigation focused on to clarify in detail the binding behav...

Neocortical morphometry in Huntington's disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes.

Mar 02, 2020

Huntington's disease (HD) is an inherited, autosomal dominant disorder that is characteristically thought of as a degenerative disorder. Despite cellular and molecular grounds suggesting HD could also...

Polyomavirus and Cytomegalovirus Infections are Risk factors for Grafts Loss in Simultaneous Pancreas and Kidney Transplant.

Mar 02, 2020

Published literature on predictors of Polyomavirus (BKV) and Cytomegalovirus (CMV) infections in Simultaneous Pancreas and Kidney (SPK) transplant and their impact on allograft outcomes remains sparse...

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