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Surgery General

TRAP1 is a predictive biomarker of platinum-based adjuvant chemotherapy benefits in patients with resected lung adenocarcinoma.

Feb 25, 2020

Platinum-based adjuvant chemotherapy after complete resection has become a standard treatment for patients with stage II to IIIA non-small cell lung cancer; however, not all patients exhibit survival ...

Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives.

Feb 25, 2020

Morphine and its derivatives play inevitably important role in the μ-opioid receptor (MOR) targeted antinociception. A structure-activity relationship study is presented for novel and known orvinol a...

microRNA-422a Inhibits DCC Expression in a Manner Dependent on SNP rs12607853.

Feb 25, 2020

DCC netrin 1 receptor (DCC) affects the structure and function of the dopamine circuitry, which in turn affects the susceptibility to developing addiction. In a previous study, we found that single nu...

The Burden of Platelet Transfusions in Patients With CLD

Feb 23, 2020

Clinical guidelines recommend that patients who undergo invasive procedures have a platelet count level above 50x10^9/L; these guidelines historically have applied to all patients and do not specifica...

Survival After Pediatric Kidney Transplant Drastically Improved

Feb 20, 2020

THURSDAY, Feb. 20, 2020 (HealthDay News) -- There has been an increase in survival after pediatric kidney transplantation since 1970, according to a study published online Feb. 13 in the Clinical Jour...

Turn-in Flap: 10 Years' Experience of a Single Institution in Saudi Arabia.

Feb 18, 2020

Background and objective Cephalic excision of the lateral crus is the most used procedure in rhinoplasty when attempting to make the nasal tip smaller or narrower to improve the definition. However, d...

Auxiliary usage of botulinum toxin A in plastic surgery in China.

Feb 18, 2020

Currently, botulinum toxin A (BTA) is mainly used in the treatment of muscle spasms and in cosmetic procedures, and its cosmetic indications are expanding rapidly. There have been sporadic reports foc...

Autologous platelet concentrates in maxillofacial regenerative therapy.

Feb 18, 2020

Platelet concentrates have emerged as innovative autologous blood products that enhance tissue healing and regeneration in regenerative therapy. A common feature of these products is their higher than...

Association of Socioeconomic, Personality, and Mental Health Factors With Health-Related Quality of Life in Patients With Facial Palsy.

Feb 18, 2020

Knowledge of factors associated with health-related quality of life in patients with facial palsy may aid in better interpreting outcomes of research and treatment.To identify factors associated with ...

Ideal xenograft or a perfect bone substitute?-A retrospective review and analysis of the historical concept of ivory implants in orthopaedics.

Feb 18, 2020

Surgical treatment of fractures has evolved with the development of anaesthesia in 1846. Experiments with different implants both organic and non-organic had led to introduction of sometimes extremely...

Impact of 3D Printed Calcaneal Models on Fracture Understanding and Confidence in Orthopedic Surgery Residents.

Feb 18, 2020

To determine if three-dimensionally printed (3Dp) fracture models can improve orthopedic trainee education.A prospective comparison study of orthopedic trainees and attending surgeons was performed, w...

Analysis of Different Levels of Structured Reporting in Knee Magnetic Resonance Imaging.

Feb 18, 2020

The aim of this study is to investigate the most appropriate knee MRI report template that not only provides structure and consistency, but also allows enough narrative freedom for the logical organiz...

[Osteoid osteoma of the hand - Diagnostics and operative treatment].

Feb 18, 2020

Osteoid osteoma is a rare benign bone tumor displaying typical clinical symptoms and radiological signs in most cases. Characteristic symptoms are nocturnal pain alleviated by non-steroid antiinflamm...

Neural Cell Adhesion Molecule (NCAM) a Serum Biomarker Indicative for the Severity of Cervical Spondylotic Myelopathy.

Feb 18, 2020

Peripheral blood samples were obtained from 25 patients with cervical spondylotic myelopathy (CSM) and 13 healthy volunteers.Our aim was to investigate the significance of neurodegenerative biomarkers...

Residency Selection Preferences and Orthopaedic Career Perceptions: A Notable Mismatch.

Feb 18, 2020

Despite near-equal enrollment of males and females in medical schools, orthopaedic surgery continues to have one of the lowest percentage of female orthopaedic residents. This suggests there may be fa...

Natural polyphenols in preclinical models of epilepsy.

Feb 18, 2020

Natural polyphenols are being tested both in preclinical and clinical settings for the treatment of different neurological disorders. The article describes the outcome of three polyphenols, resveratro...

Early growth outcomes in very low birth weight infants with bronchopulmonary dysplasia or fetal growth restriction.

Feb 18, 2020

To assess the growth outcomes at 18 months corrected age in very low birth weight (VLBW) infants compared to standardized norms, and in VLBW infants with and without bronchopulmonary dysplasia (BPD) o...

Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats.

Feb 18, 2020

There is evidence to suggest that hypertension involves a chronic low-grade systemic inflammatory response; however, the underlying mechanisms are unclear. To further understand the role of inflammati...

Risk of Permanent Hypoparathyroidism After Total Thyroidectomy for Benign Disease: A Nationwide Population-based Cohort Study From Sweden.

Feb 18, 2020

To investigate the prevalence and risk factors for permanent hypoparathyroidism after total thyroidectomy for benign disease in a population-based setting with data independent of input of complicatio...

Management and Outcome of Local Regrowths in a Watch-and-wait Prospective Cohort for Complete Responses in Rectal Cancer.

Feb 18, 2020

To evaluate the management and oncological outcomes of rectal cancer patients with local regrowth in a watch-and-wait (W&W) program.Approximately 15%-30% of patients with a clinical complete response ...

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