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Surgery General

A randomised, double-blind, crossover, dose ranging study to determine the optimal dose of oral opioid to treat breakthrough pain for patients with advanced cancer already established on regular opioids.

Feb 17, 2020

Pain in people with advanced cancer is prevalent. When a stable dose of opioids is established, people still experience episodic breakthrough pain for which dosing of an immediate release opioid is us...

Associations between Neighborhood-Level Factors and Opioid-Related Mortality: A Multilevel Analysis using Death Certificate Data.

Feb 17, 2020

To identify associations between opioid-related mortality and neighborhood-level risk factors.Cross-sectional study.Massachusetts, USA.Using 2011-2014 Massachusetts death certificate data, we identifi...

Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients.

Feb 17, 2020

Deregulated circulating microRNAs (miRNAs) are potential biomarkers for the early detection and prognosis prediction of non-small-cell lung cancer (NSCLC). The aim of the present study was to investig...

The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non-small cell lung cancer.

Feb 17, 2020

The prognostic value of platelet distribution width (PDW) is different in various malignancies. The purpose of this study was to identify the relationship between preoperative PDW and survival in pati...

Predictive value of CD73 expression for the efficacy of immune checkpoint inhibitors in NSCLC.

Feb 17, 2020

CD73 induces the dephosphorylation of adenosine monophosphate converting it to adenosine, enabling malignancies to escape from immune surveillance. Although CD73 overexpression has been reported to be...

Cone-beam CT radiomics features might improve the prediction of lung toxicity after SBRT in stage I NSCLC patients.

Feb 17, 2020

Stereotactic body radiotherapy (SBRT) is the standard care for inoperable early stage non-small cell lung cancer (NSCLC). The purpose of our study was to investigate whether a prediction model based o...

Impact of resection margin status on survival in pancreatic cancer patients after neoadjuvant treatment and pancreatoduodenectomy.

Jan 30, 2020

Resection margin status has been recognized as an independent prognostic factor on overall survival in pancreatic cancer patients undergoing surgical resection. However, its impact after neoadjuvant t...

Burden of emergency pediatric surgical procedures on surgical capacity in Uganda: a new metric for health system performance.

Jan 27, 2020

The significant burden of emergency operations in low- and middle-income countries can overwhelm surgical capacity leading to a backlog of elective surgical cases. The purpose of this investigation wa...

Laparoscopic Liver Transplantation: Dream or Reality? The First Step With Laparoscopic Explant Hepatectomy.

Jan 27, 2020

To introduce the laparoscopic approach in liver transplant recipients.Despite the increasingly frequent use of laparoscopy in living donor hepatectomy, the laparoscopic approach has never been reporte...

Consensus Statement on Robotic Mastectomy-Expert Panel From International Endoscopic and Robotic Breast Surgery Symposium (IERBS) 2019.

Jan 27, 2020

To achieve a consensus statement on robotic mastectomy.Robotic-assisted surgery has gained much attention especially the results of few case series reporting on the technical feasibility, safety and e...

Perceptions on gender disparity in surgery and surgical leadership: A multicenter mixed methods study.

Jan 27, 2020

Our objective was to identify perceptions of the environment for women in surgery among 4 academic institutions.Faculty surgeons and senior surgery residents were randomly selected to participate in a...

Emerging microbiology diagnostics for transplant infections: On the cusp of a paradigm shift.

Jan 24, 2020

In light of the heightened risk for infection associated with solid organ and hematopoietic stem cell transplantation, rapid and accurate microbiology diagnostics are essential to the practice of tran...

Neoadjuvant Chemoradiotherapy and Liver Transplantation for Unresectable Hilar Cholangiocarcinoma: The Irish Experience of the Mayo Protocol.

Jan 24, 2020

Pioneered by the Mayo Clinic, multimodal therapy with neoadjuvant chemoradiotherapy and orthotopic liver transplant has emerged as a promising option for unresectable hilar cholangiocarcinoma. This st...

Novel Organ Perfusion and Preservation Strategies in Transplantation - where are we going in the UK?

Jan 24, 2020

This review article focuses on current clinical outcomes with novel perfusion strategies in organ transplantation. Broadly, these approaches can be divided into in-situ regional perfusion in the donor...

Mobile Health Technology for Pediatric Symptom Monitoring: A Feasibility Study.

Jan 24, 2020

Pediatric Blood and Marrow Transplant (PBMT) patients experience significant symptom distress. Mobile health (mHealth) technologies can be leveraged to improve understanding of the patient's symptom e...

Microsurgical clipping compared to new and most advanced endovascular techniques in the treatment of unruptured middle cerebral artery aneurysms: a meta-analysis in the modern era.

Jan 24, 2020

Analyzing occlusion, complications rate and clinical results in unruptured saccular middle cerebral artery aneurysms comparing clipping to the most advance and newer endovascular techniques.We conduc...

Effect of remote ischaemic conditioning on coagulation function as measured by whole blood impedance aggregometry and rotational thromboelastometry in off-pump coronary artery bypass surgery: A randomised controlled trial.

Jan 24, 2020

Remote ischaemic conditioning (RIC) has been shown to prevent platelet activation during ablation for atrial fibrillation. RIC has also been associated with more postoperative transfusion in the off-p...

The Effect of Postoperative Complications After Minimally Invasive Esophagectomy on Long-term Survival: An International Multicenter Cohort Study.

Jan 24, 2020

Esophagectomy is a technically challenging procedure, associated with significant morbidity. The introduction of minimally invasive esophagectomy (MIE) has reduced postoperative morbidity.Although the...

Surveillance for HCC after Liver Transplantation: Increased monitoring may yield aggressive treatment options and improved postrecurrence survival.

Jan 24, 2020

Currently, no surveillance guidelines for hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) exist. In this retrospective, multicenter study, we have investigated the role of s...

A single-center experience in the management of head and neck lymphangiomas.

Jan 24, 2020

Lymphangiomas are relatively uncommon head and neck region lymphatic malformations. Although surgery can be still considered the mainstay of treatment, sclerotherapy by OK-432 is becoming a widespread...

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