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Orthopedics

Pediatric Gaucher disease with intermediate type 2-3 phenotype associated with parkinsonian features and levodopa responsiveness.

Aug 30, 2021

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by a deficiency of acid β-glucosidase encoded by the GBA gene. In patients with GD, childhood onset parkinsonian featu...

The Versatility of the DCIA Free Flap: A Forgotten Flap? Systematic Review and Meta-Analysis.

Aug 30, 2021

 Studies reporting on the deep circumflex iliac artery (DCIA) free flap are restricted to a limited number of patients and areas of application. The aim of this review was to assess the reliability ...

Learning Environment Issues Tied to Medical School Burnout

Aug 29, 2021

THURSDAY, Aug. 26, 2021 (HealthDay News) -- Medical students who experience mistreatment and perceive a less favorable learning environment are more likely to develop higher levels of exhaustion and d...

Medical Fiction: Frank and the Door

Aug 27, 2021

This is one of a collection of stories that are like “Final Destination” meets “The Monkey’s Paw” (W. W. Jacobs, 1902). As such, they are tragedies more than either mysteries or horror, an...

State Limits on Initial Opioid Rx Duration May Influence Prescribing

Aug 26, 2021

WEDNESDAY, Aug. 25, 2021 (HealthDay News) -- State laws restricting the duration of initial opioid prescriptions are associated with changes in opioid prescribing, according to a research letter publi...

DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis.

Aug 26, 2021

Intervertebral disc degeneration (IVDD) is a main cause of low back pain that is associated with extracellular matrix (ECM) degradation and inflammation. This study aims to investigate the role of DNM...

Effects of SiO2 Incorporation on the Flexural Properties of a Denture Base Resin: An In Vitro Study.

Aug 26, 2021

 The aim of this study was to evaluate the effects of the addition of low-silicon dioxide nanoparticles (nano-SiO) on the flexural strength and elastic modulus of polymethyl methacrylate (PMMA) dent...

Association of Fpr1 gene expression with osteogenesis and adipogenesis of adipose derived stem cells.

Aug 26, 2021

Formyl peptide receptors (Fprs) play fundamental roles in multiple cell functions including promotion of osteogenesis and bone fracture healing. In this study, the role of Fpr1 gene in osteogenic and ...

A systematic dissection of human primary osteoblasts at single-cell resolution.

Aug 26, 2021

Human osteoblasts are multifunctional bone cells, which play essential roles in bone formation, angiogenesis regulation, as well as maintenance of hematopoiesis. However, the categorization of primary...

Preliminary Histological Evaluation of the Application of Ozone in the First Days of Orthodontic Force Induction in Animal Model.

Aug 26, 2021

 The aim of the study is to histologically evaluate the effect of ozone therapy on orthodontic force induction in an animal model. Twenty-four Wistar rats were divided into three groups ( = 8). A ...

Cycling Common Cause of Sports-Linked Traumatic Spinal Injury

Aug 24, 2021

TUESDAY, Aug. 24, 2021 (HealthDay News) -- Sports-related traumatic spinal injury (TSI) mainly occurs in men, with cycling injuries the most frequent mechanism of injury, according to a study publishe...

Medical Fiction: Inattentive Tim

Aug 23, 2021

This is one of a collection of stories that are like “Final Destination” meets “The Monkey’s Paw” (W. W. Jacobs, 1902). As such, they are tragedies more than either mysteries or horror, an...

Lower-limb injury in elite Australian football: A narrative review of kinanthropometric and physical risk factors.

Aug 23, 2021

This review aims to provide a succinct and critical analysis of the current physical and mechanical demands of elite Australian football while examining lower-limb injury and the associated physical a...

Factors that influence the distribution of impact force relative to the proximal femur during lateral falls.

Aug 23, 2021

In-vivo fall simulations generally evaluate hip fracture risk through differences in impact force magnitude; however, the distribution of force over the hip likely modulates loading and subsequent inj...

Single layer fascia patchwork closure for extended endoscopic transsphenoidal transtuberculum transplanum approach: Deep suturing technique and preliminary results.

Aug 23, 2021

To describe a single layer fascia patchwork closure (FPWC) without nasoseptal flap (NSF), and compare the postoperative cerebrospinal fluid (CSF) leakage between FPWC using NSF and single layer FPWC w...

Comparison between Lu-iPSMA and Ac-iPSMA dosimetry at a cellular level in an animal bone metastasis model.

Aug 23, 2021

The recent use of prostate-specific membrane antigen as a biological target have improved the theragnostic approach to prostate and other types of cancer. Radiopharmaceuticals based on PSMA inhibitors...

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery.

Aug 19, 2021

Low back pain is the leading cause of disability worldwide and one of the most common reasons for seeking healthcare. Despite numerous care strategies, patients with low back pain continue to exhibit ...

Optimizing pediatric histrelin implantation to improve success rates in clinic without sedation.

Aug 19, 2021

The purpose of this study was to review our success rate performing the histrelin implant procedure in clinic without sedation.A retrospective study was performed for histrelin implant procedures done...

Curcumin Inhibition of TGFβ signaling in bone metastatic breast cancer cells and the possible role of oxidative metabolites.

Aug 19, 2021

TGFβ signaling promotes progression of bone-metastatic (BMET) breast cancer (BCa) cells by driving tumor-associated osteolysis, a hallmark of BCa BMETs, thus allowing for tumor expansion within bone....

Association of Klotho with physical performance and frailty in middle-aged and older adults: A systematic review.

Aug 19, 2021

Ageing is an inevitable process of physical deterioration that impairs functional autonomy and quality of life, becoming a public health issue. Since the percentage of people over 60 years is increa...

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