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Orthopedics

Crosstalk between CML cells with HUVECS and BMSCs through CML derived exosomes.

Oct 15, 2020

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL chimeric protein. Imatinib is first...

BMD Testing Rates Low in Men Initiating ADT for Prostate Cancer

Oct 14, 2020

TUESDAY, Oct. 13, 2020 (HealthDay News) -- The rate of bone mineral density (BMD) testing is low among men with prostate cancer initiating androgen deprivation therapy (ADT), according to a study publ...

Functional outcome of gastrocnemius advancement flap augmented with short flexor hallucis longus tendon transfer in chronic Achilles tear.

Oct 12, 2020

There are various techniques of Achilles tendon (TA) repair and reconstruction in chronic Achilles tear. However, there is no clear consensus on the relevance of one method over the other. The short f...

Lisfranc injury: A review and simplified treatment algorithm.

Oct 12, 2020

Lisfranc injuries encompass large spectrum of injuries varying from low energy to high energy complex fracture dislocations. Whilst multiple complex classification systems exist; these do little to ai...

The influence of age, gender and the FKBP5 genotype on subjective health complaints in the Norwegian working population.

Oct 12, 2020

In the present study we examined the potential association between age, gender, the genetic variant FKBP5 rs9470080 and subjective health complaints.The data were collected through a three-wave nation...

Serum osteocalcin is associated with subjective stress in people with depression and type 2 diabetes.

Oct 12, 2020

Low serum osteocalcin is a risk factor for type 2 diabetes mellitus (T2DM), and osteocalcin release from bone is associated with an acute stress response in mice. Both diabetes and stress are associat...

Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma.

Oct 12, 2020

Sarcomas are rare heterogeneous tumours, derived from primitive mesenchymal stem cells, with more than 100 distinct subtypes. Radioresistance remains a major clinical challenge for sarcomas, demanding...

Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus.

Oct 12, 2020

Oxidative stress in children with type 1 DM (T1DM) may negatively affect the bone.This study included 40 children with T1DM as the patient group and 40 healthy children as the control group. Plasma al...

Lifetime Prevalence of Suicide Ideation 17.4 Percent Among Doctors

Oct 09, 2020

THURSDAY, Oct. 8, 2020 (HealthDay News) -- The lifetime prevalence of suicide ideation (SI) is 17.4 percent among physicians, while lifetime prevalence of suicide attempt (SA) is 1.8 percent, accordin...

Physical Activity, Sleep Profiles Vary in Adults With Arthritis

Oct 09, 2020

THURSDAY, Oct. 8, 2020 (HealthDay News) -- Four distinct physical activity profiles are detectable using activity monitoring among adults with arthritis, according to a study published online Oct. 6 i...

ASA: Cannabis Users May Need More Anesthesia During Surgery

Oct 09, 2020

THURSDAY, Oct. 8, 2020 (HealthDay News) -- Patients with prior cannabis use may need higher doses of intraoperative inhaled anesthetic and postoperative opioids, according to a study presented at ANES...

Early Physical Therapy Beneficial for Acute Back Pain With Sciatica

Oct 08, 2020

WEDNESDAY, Oct. 7, 2020 (HealthDay News) -- For patients with acute back pain with sciatica, those receiving early physical therapy (EPT) have improvements in the Oswestry Disability Index (OSW) score...

Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae.

Oct 08, 2020

The gut microbiota is an important contributor to both health and disease. While previous studies have reported on the beneficial influences of the gut microbiota and probiotic supplementation on bone...

Hematological and Chemical Profiles in a Porcine Model of Severe Multiple Trauma.

Oct 08, 2020

Clinical chemistry and hematological tests are widely used to monitor the clinical course of several diseases. However, these parameters are sparse in large-animal models of multiple trauma (MT). Thus...

The use of omega-3 fatty acids in the treatment of oral diseases.

Oct 08, 2020

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been reported to exert important roles in the inflammatory response. There are many inflammatory diseases in dentistry which support the administr...

Irradiation-free RIC HSCT has a tolerable safety profile and is effective therapy for pediatric bone marrow failure syndromes.

Oct 08, 2020

For patients with bone marrow failure syndromes (BMFS) who may tolerate gradual donor engraftment and achieve adequate disease control with stable mixed chimerism, RIC regimens may be preferable to my...

Optimal duration of prior endocrine therapy predicts the efficacy of Fulvestrant in a real-world study for patients with hormone receptor-positive and HER2-negative advanced breast cancer.

Oct 08, 2020

Fulvestrant 500 mg is standard of care for endocrine therapy-naive or pretreated women with hormone receptor-positive (HR+) metastatic breast cancer (MBC). This study was conducted to explore the pot...

Contemporary Population-Based Analysis of Bone Mineral Density Testing in Men Initiating Androgen Deprivation Therapy for Prostate Cancer.

Oct 08, 2020

Androgen deprivation therapy (ADT) is a cornerstone of treatment for advanced prostate cancer (PCa); however, it accelerates the loss of bone mineral density (BMD), which increases fracture risk. Guid...

Routine Preop Stress Testing Down in Hip, Knee Arthroplasty

Oct 07, 2020

TUESDAY, Oct. 6, 2020 (HealthDay News) -- From 2006 to 2017, the frequency of preoperative stress testing declined annually among patients undergoing elective total hip or total knee arthroplasty, acc...

Hydroxychloroquine Not Beneficial for SARS-CoV-2 Preexposure Prophylaxis

Oct 07, 2020

TUESDAY, Oct. 6, 2020 (HealthDay News) -- Hydroxychloroquine administered for eight weeks as preexposure prophylaxis has no clinical benefit in hospital-based health care workers (HCWs) exposed to pat...

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