To explore the causal relationship between dietary habits and five major mental disorders using the two-sample Mendelian randomization (MR) analysis.
This study was based on the summary data of the genome-wide association study (GWAS) on diet and five major mental disorders in the European population. The genetic locus data of five major mental disorders (mania, bipolar disorder, manic depression, depression, schizophrenia) from those who never eat eggs, dairy, wheat, and sugar were used. Two-sample MR analysis was conducted to evaluate the causal relationship between diet and five major mental disorders.
This study revealed a causal relationship between “Never eat Wheat products” and all five types of mental disorders (mania, bipolar disorder, manic depression, depression, schizophrenia), demonstrating a significant negative correlation (P 0.05). Furthermore, the study found that the statement “Never eat eggs, dairy, wheat, sugar: I eat all of the above” had a causal relationship with mania, bipolar disorder, and manic depression, showing a significant positive correlation (P 0.05).
There was a negative correlation between never eating wheat products and the five mental disorders (mania, bipolar disorder, manic depression, depression, schizophrenia), indicating that never eating wheat products may reduce the risk of mental disorders.
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