There is little difference in choroidal and microvascular changes among patients with Usher syndrome type 2 (USH2), despite their relatively younger age, versus nonsyndromic retinitis pigmentosa (nsRP), ac – cording to results published in the European Journal of Ophthalmology. Alessio Antropoli, MD, and colleagues compared syn – dromic and nonsyndromic forms of USH2A-related retinopathy to verify whether phenotype could affect anatomical modifications and microvascular impairment in 34 eyes from 18 patients. Thirteen patients were diagnosed with USH2; the others had nsRP. Patients with syndromic RP were younger and had poorer visual acuity. Patients with USH2 had a greater prevalence of cystroid macular edema and thicker choroids, though this was not statistically significant, and there were no statistical differences in other quantitative OCT and OCTA parameters between groups. According to Dr. Antropoli and colleagues, larger longitudinal studies are warranted to confirm the absence of differences between nsRP and USH2.