Hyaluronic Acid (HA) is a glycosaminoglycan widely used in the fields of orthopedics, ophthalmology, and aesthetic medicine due to its significant ability to reduce the synthesis of pro-inflammatory proteins and its activity against oxidative stress, a feature of many degenerative illnesses.
The objective of the present review is to provide a comprehensive narrative review of the most recent literature on the use of HA in Andrology in order to facilitate the use of this therapeutic device in the common clinical practice of many physicians. Specific conditions covered in the review are Peyronie Disease (PD), Premature Ejaculation (PE) and Penile Enlargement.
A broad and comprehensive literature search included Medline, EMBASE, and the Cochrane Libraries, with no time restriction up to December 2020 and restricted to English language publications. Unpublished studies were not included. The study was registered as “The role of HA in andrology: a systematic review and meta-analysis” in PROSPERO with the ID CRD42021223416.
HA is a valid choice for the treatment of PD in terms of resolution of the acute phase of disease and of contributing to stabilizing the disease as a bridge to potential surgery. Data furthermore suggests HA is frequently associated with an overall clinical improvement, allowing the patient to resume normal sexual activity. This article is protected by copyright. All rights reserved With regard to PE, data suggests HA-based treatments were effective in prolonging intra-vaginal ejaculation time; furthermore, HA was found to be safe and well-tolerated, with main adverse events limited to local discomfort, ecchymosis, papule formation and glans numbness, all of which were reported to resolve spontaneously. Lastly, with regard to penile enlargement, the overall perception of experts is that HA may be an extremely well-tolerated compound with potential for application in specific areas of male sexual health that are often neglected as compared to more common, and relatively simpler to treat, conditions.

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